Strain information
NBRP Rat No: 0446
Strain name
: SHR.Cg-
Lepr
cp
/NDmcr
Commmon Name:
Rat Genome Database
Principal Investigator:
Yukio Yamori Disease Model Cooperative Research Association Seisan Kaihatsukagakukenkyujyo 3F-Simogamo Morimotocho15-Sakyoku 606-0805 Kyoto Japan
Tel: 075-744-0071 Fax: 075-744-0071
Email: dmcra@j.email.ne.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
Inbred Generations
?
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Lepr: leptin receptor
Origin
Nonsense mutation of leptin receptor gene in the obese spontaneously hypertensive Koletsky rat was transferred to SHR/N strain at NIH. This strain has been maintained at Disease Model Cooperative Research Association (DMCRA) scince 1999. (Sep 24, 2009)
Strain characteristics
obesity, hypertension and diabetes
Breeding Conditions
Maintained by crossing heterozygotes of the
fa
k
/
fa
k
locus.
Genotyping
References
Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K, Koletsky RJ.
Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat.
Nat Genet. 1996 Oct;14(2):130-1
Additional strain information