Strain information  NBRP Rat No: 0447  Strain name: SHRSP.Z-Leprfa/IzmDmcr  Commmon Name: SHRSP fatty, SHRSP.ZF Rat Genome Database Principal Investigator:  Yukio Yamori   Disease Model Cooperative Research Association       Seisan Kaihatsukagakukenkyujyo 3F-Simogamo Morimotocho15-Sakyoku    606-0805 Kyoto     Japan Tel: 075-744-0071    Fax: 075-744-0071 Email: dmcra@j.email.ne.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color   Inbred Generations   Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Lepr: leptin receptor Origin The Leprfa allele was backcrossed from ZF strain onto SHRSP/Izm by 12 backcrossing. (Sep 14, 2009) Strain characteristics obesity, hypertension, diabetes and cerebrovascular disorder (Sep 14, 2009) Breeding Conditions Maintained by crossing heterozygotes of the fa/fa locus. Genotyping References Hiraoka-Yamamoto J, Nara Y, Yasui N, Onobayashi Y, Tsuchikura S, Ikeda K. Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats. Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9. Additional strain information