Strain information
 NBRP Rat No: 0447  Strain name: SHRSP.Z-Leprfa/IzmDmcr  Commmon Name: SHRSP fatty, SHRSP.ZF Rat Genome Database
Principal Investigator:  Yukio Yamori   Disease Model Cooperative Research Association       Seisan Kaihatsukagakukenkyujyo 3F-Simogamo Morimotocho15-Sakyoku    606-0805 Kyoto     Japan
Tel: 075-744-0071    Fax: 075-744-0071 Email:
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  
Inbred Generations  
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lepr: leptin receptor
Origin The Leprfa allele was backcrossed from ZF strain onto SHRSP/Izm by 12 backcrossing. (Sep 14, 2009)
Strain characteristics obesity, hypertension, diabetes and cerebrovascular disorder (Sep 14, 2009)
Breeding Conditions Maintained by crossing heterozygotes of the fa/fa locus.
References Hiraoka-Yamamoto J, Nara Y, Yasui N, Onobayashi Y, Tsuchikura S, Ikeda K.
Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.
Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.
Additional strain information