Strain information
 NBRP Rat No:   Strain name: MPR/Iar  Commmon Name: MPR-Arsbabd/Iar, MPR Rat Genome Database
Principal Investigator:  Tetsuo Kunieda  Okayama University Graduate School of Natural and Technology       3-1-1 Tsushima-naka Okayama    700-8530 Okayama     Japan
Tel: 086-251-8314     Fax: 086-251-8388 Email:
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  F?
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must agree on collaborative research with the DEPOSITOR. Any form of publications of data resulting from the use of the BIOLOGICAL RESOUCE require co-authorship.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Arsb: arylsulfatase B
Origin This mutant was found as a rat exhibits facial and skeletal dysmorphism in the Ishibashi hairless rat strain at Imamichi Institute for Animal Reproduction in 1988 (Yoshida, 1993). (Jun 3, 2010)
Strain characteristics MPR rats have smaller bodies, shorter limbs, facial dysmorphia, dysostosis multiplex, and increased urinary excretion of glucosaminoglycans (GAGs) and these features become evident after 3 weeks of age (Yoshida, 1993). Biochemical analyses demonstrated that the excreted CAG was dermantan sulfate and the activity of hepatic arylsulfatase B was lower than that of normal rats. MPR rats have a 1-bp insertion (507insC) which resulting in a frame shift mutation in the arylsulfatase B (Arsb) gene on rat chromosome 2 (Kunieda, 1995). The MPR is a disease model for mucopolysaccharidosis VI. (Jun 3, 2010)
Breeding Conditions Homozygous Arsb rats are difficult to breed and are therefore maintained by crossing heterozygous individuals (segregating inbred strain).
Genotyping Genotyping protocol for Arsb
References Yoshida M, Noguchi J, Ikadai H, Takahashi M, Nagase S.
Arylsulfatase B-deficient mucopolysaccharidosis in rats.
J Clin Invest. 91(3):1099-104, 1993.

Kunieda T, Simonaro CM, Yoshida M, Ikadai H, Levan G, Desnick RJ, Schuchman EH.
Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation.
Genomics. 10;29(3):582-7, 1995.
Additional strain information