Strain information  NBRP Rat No: 0471  Strain name: F344-Hrkrh/Kyo  Commmon Name: F344-krh/Kyo, Hairless Kyoto, Hanako Rat Genome Database Principal Investigator:  Tomoji Mashimo  The University of Tokyo, The Institute of Medical Science       4-6-1 Shirokanedai-Minatoku-Tokyoto    108-8639      Japan Tel: 03-6409-2489    Fax:  Email: mashimo@ims.u-tokyo.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations   Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Hr: hairless Origin A mutant rat showing abnormal skin phenotype was found in the G1 rats produced by ENU mutagenesis (phenotype-driven) using F344/Nslc. Also called Kyoto rhino rat (krh). Strain characteristics Coat hair start fall at 4-5 weeks of age and completely fall out by 8 weeks of age. krh rats develop wrinkled skin, cystic hair canals and long curved nails by 4 months of age. Genetic analysis revealed a nonsense mutation in the hairless gene Hr on chromosome 15. krh rats also develop focal glomerulosclerosis (FGS) and proteinuria. (Kuramoto, 2010) (Oct 4, 2010) Breeding Conditions Male rats show good breeding performance. Females are fertile, but have poor breeding performance. Maintained in heterozygous condition by backcrossing onto F344/NSlc. Genotyping Determined by phenotype. Genotyping protocol for Hr References Yoshimasu T, Kuramoto T, Kaminaka C, Kanazawa N, Yamamoto Y, Furukawa F. Efficacy of 0.1% adapalene in a non-inflammatory Kyoto Rhino Rat acne model. J Dermatol Sci. 76(2):143-8, 2014. Kuramoto T, Kuwamura M, Tagami F, Mashimo T, Nose M, Serikawa T. Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair loss and exhibit focal glomerulosclerosis. Exp Anim. 60(1):57-63, 2011. Additional strain information