Strain information
 NBRP Rat No: 0478  Strain name: DA.Cg-Foxn1rnu Lystbg/Slc  Commmon Name: DA-Foxn1rnu Lystbg/Slc, DA/Slc-Foxn1rnu Lystbg, DA/Slc-bg rnu Rat Genome Database
Principal Investigator:  Norio Masui  Japan SLC,Inc.       3-5-1, Aoi-Higashi, Naka-ku, Hamamatsu city    433-8114 Shizuoka     Japan
Tel: 053-437-5348    Fax: 053-436-4320 Email: n-masui@jslc.co.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  dark agouti （heterozygous）、　hairless （homozygous）
Inbred Generations  ?＋N16
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Foxn1: forkhead box N1 ,Lyst: lysosomal trafficking regulator
Origin Three strains of rats (DA/Slc, DA-Foxn1rnu and DA/Ham-Lystbg) were selected to establish this congenic strain. DA/Ham-Lystbg strain was derived from the beige mutation found in the inbred colony of the DA/Ham at Hamamatsu University of Medicine in 1985. DA-Foxn1rnu strain was produced by cross-intercross method with five backcross generation between an athymic nude rat and the DA/Slc strain. By crossing these three strains, DA-Foxn1rnu Lystbg double mutant rat strain was established (Masui, 2004). (May 21, 2009)
Strain characteristics This mutant strain is an athymic beige-nude rat and shows a bleeding tendency and impaired NK cell activity. (May 21, 2009)
Breeding Conditions Both male and female of heterozygous for Foxn1rnu Lystbg double mutant are fertile and it is also possible to cross between Foxn1rnu/+ and Lystbg/Lystbg rats. (May 21, 2009)
Genotyping Genotyping protocol for Foxn1
References Masui N, Nishikawa T, Takagi Y, Mori M, Suzuki T, Sato K.
The rat lysosomal trafficking regulator (Lyst) gene is mapped on the telomeric region of chromosome 17.
Exp Anim. 2003 52(1):89-91.

Masui N, Mori M, Nishikawa T, Takagi Y, Asai H, Yanabe M, Yamasaki K, Serikawa T, Sato K.
An allele-specific genotyping method for rat lyst (lysosomal trafficking regulator) gene.
Exp Anim. 2004 53(1):77-80.

Masui N, Nishikawa T, Takagi Y, Kimura H, Mori M, Yokose S, Asai H, Gonda T, Yanabe M, Sato K.
Establishment of a set of combined immunodeficient DA/Slc-Foxn1(rnu) Lyst(bg) congenic rat strains.
Exp Anim. 2004 53(5):399-407.
Additional strain information rnu