NBRP Rat No: 0511 |
Strain name: ZDF-Leprfa/CrlCrlj |
Commmon Name: ZDF, ZDF/CrlCrlj |
Rat Genome Database |
Principal Investigator: |
Shinya Takahashi Charles river laboratories Japan 11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama 222-0033 Kanagawa Japan |
Tel: 045(474)9340 Fax: 045(474)9341 |
Email: web_order@jp.crl.com |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
Four principal coat color Variants |
Inbred Generations |
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Usage Restrictions |
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Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
Lepr: leptin receptor |
Origin |
Some rats of colony of outbred Zucker rats kept in Eli Lilly Research Laboratories were transferred to Indiana University Medical School in 1977. Selection and inbreeding was performed in 1981 and inbred ZDF strain was established in 1985. To Charles River Laboratories, Inc. in 2001. To Charles River Japan, Inc. in 2005. Zucker Diabetic Fatty. (May 28, 2010) |
Strain characteristics |
The ZDF rat is an animal model for obese, type 2 diabetes.
When fed with a diet of Purina 5008, homozygous males (Leprfa/Leprfa) develop obesity, hyperlipidemia, fasting hyperglycemia, and Type 2 diabetes. Wildtype (+/+) and heterozygous (Leprfa/+) lean genotypes remain normoglycemic. (May 28, 2010) |
Breeding Conditions |
Homozygous rats are infertile. (May 28, 2010) |
Genotyping |
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References |
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Additional strain information |
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