Strain information
 NBRP Rat No: 0511  Strain name: ZDF-Leprfa/CrlCrlj  Commmon Name: ZDF, ZDF/CrlCrlj Rat Genome Database
Principal Investigator:  Shinya Takahashi  Charles river laboratories Japan       11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama    222-0033 Kanagawa     Japan
Tel: 045(474)9340     Fax: 045(474)9341 Email:
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  Four principal coat color Variants
Inbred Generations  
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lepr: leptin receptor
Origin Some rats of colony of outbred Zucker rats kept in Eli Lilly Research Laboratories were transferred to Indiana University Medical School in 1977. Selection and inbreeding was performed in 1981 and inbred ZDF strain was established in 1985. To Charles River Laboratories, Inc. in 2001. To Charles River Japan, Inc. in 2005. Zucker Diabetic Fatty. (May 28, 2010)
Strain characteristics The ZDF rat is an animal model for obese, type 2 diabetes. When fed with a diet of Purina 5008, homozygous males (Leprfa/Leprfa) develop obesity, hyperlipidemia, fasting hyperglycemia, and Type 2 diabetes. Wildtype (+/+) and heterozygous (Leprfa/+) lean genotypes remain normoglycemic. (May 28, 2010)
Breeding Conditions Homozygous rats are infertile. (May 28, 2010)
Additional strain information