Strain information  NBRP Rat No: 0511  Strain name: ZDF-Leprfa/CrlCrlj  Commmon Name: ZDF, ZDF/CrlCrlj Rat Genome Database Principal Investigator:  Shinya Takahashi  Charles river laboratories Japan       11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama    222-0033 Kanagawa     Japan Tel: 045（474）9340     Fax: 045（474）9341 Email: web_order@jp.crl.com Preservation Status:   Embryo        Sperm       Living Animals Coat Color  Four principal coat color Variants Inbred Generations   Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Lepr: leptin receptor Origin Some rats of colony of outbred Zucker rats kept in Eli Lilly Research Laboratories were transferred to Indiana University Medical School in 1977. Selection and inbreeding was performed in 1981 and inbred ZDF strain was established in 1985. To Charles River Laboratories, Inc. in 2001. To Charles River Japan, Inc. in 2005. Zucker Diabetic Fatty. (May 28, 2010) Strain characteristics The ZDF rat is an animal model for obese, type 2 diabetes. When fed with a diet of Purina 5008, homozygous males (Leprfa/Leprfa) develop obesity, hyperlipidemia, fasting hyperglycemia, and Type 2 diabetes. Wildtype (+/+) and heterozygous (Leprfa/+) lean genotypes remain normoglycemic. (May 28, 2010) Breeding Conditions Homozygous rats are infertile. (May 28, 2010) Genotyping References Additional strain information