Strain information
 NBRP Rat No: 0476  Strain name: LEC.W-Tg(CAG-Zfml)26Ncms/Ncms  Commmon Name: LEC.Wistar-Tg(CAG-Zfml)26Ncms/Ncms, LEC.Wistar-Tg(CAG-Np220)26Ncms, Np220トランスジェニックラット Rat Genome Database
Principal Investigator:  Ichiro Miyoshi  Nagoya City University Graduate School of Medical Sciences       1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya    466-8601 Aichi     Japan
Tel: 052-853-8109    Fax:  052-841-6187 Email: msd0831@hotmail.com
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  cinnamon
Inbred Generations  F10
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 放射線感受性
 Control Strain  Marker Strain
Gene Affected Zfml (Zfp638): zinc finger protein 638
Origin CAG promoter driven Zfml cDNA isolated from BN strain was injected into Crlj:WI (Wistar). Thereafter this congenic strain was established by backcrossing the transgenic rats to LEC rats for 10 generation. (Oct 30, 2009)
Strain characteristics On the hypothesis that Zfml is the causative gene for radiation sensitivity of LEC rats, rescue analysis using transgenic rats was conducted. But the transgenic rats showed no change of the radiation sensitivity and it appeared that Zfml was not the causative gene. (Oct 30, 2009)
Breeding Conditions
Genotyping
References
Additional strain information