Strain information

Back to the list 407 / 882

NBRP Rat No: 0477

Strain name: LEC.W-Tg(CAG-Zfml)30Ncms/Ncms

Commmon Name: LEC.Wistar-Tg(CAG-Zfml)30Ncms/Ncms, LEC.Wistar-Tg(CAG-Np220)30Ncms, Np220トランスジェニックラット

Rat Genome Database

Principal Investigator:

Ichiro MiyoshiNagoya City University Graduate School of Medical Sciences

Preservation Status:

Embryo Sperm Living Animals

Coat Color

cinnamon

Inbred Generations

F10

Usage Restrictions

In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Zfml (Zfp638): zinc finger protein 638

Origin

CAG promoter driven Np220 cDNA isolated from BN strain was injected into Crlj:WI (Wistar). Thereafter this congenic strain was established by backcrossing the transgenic rats to LEC rats for 10 generation. (Oct 30, 2009)

Strain characteristics

On the hypothesis that Zfml is the causative gene for radiation sensitivity of LEC rats, rescue analysis using transgenic rats was conducted. But the transgenic rats showed no change of the radiation sensitivity and it appeared that Zfml was not the causative gene. (Oct 30, 2009)

Breeding Conditions

Genotyping

References

Additional strain information (Japanese only)