Strain information
NBRP Rat No: 0477
Strain name
: LEC.W-Tg(CAG-Zfml)30Ncms/Ncms
Commmon Name: LEC.Wistar-Tg(CAG-Zfml)30Ncms/Ncms, LEC.Wistar-
Tg(CAG-Np220)30Ncms
, Np220トランスジェニックラット
Rat Genome Database
Principal Investigator:
Ichiro Miyoshi Nagoya City University Graduate School of Medical Sciences 1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya 466-8601 Aichi Japan
Tel: 052-853-8109 Fax: 052-841-6187
Email: msd0831@hotmail.com
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
cinnamon
Inbred Generations
F10
Usage Restrictions
In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others 放射線感受性
Control Strain
Marker Strain
Gene Affected
Zfml (Zfp638): zinc finger protein 638
Origin
CAG promoter driven Np220 cDNA isolated from BN strain was injected into Crlj:WI (Wistar). Thereafter this congenic strain was established by backcrossing the transgenic rats to LEC rats for 10 generation. (Oct 30, 2009)
Strain characteristics
On the hypothesis that Zfml is the causative gene for radiation sensitivity of LEC rats, rescue analysis using transgenic rats was conducted. But the transgenic rats showed no change of the radiation sensitivity and it appeared that Zfml was not the causative gene. (Oct 30, 2009)
Breeding Conditions
Genotyping
References
Additional strain information