Strain information
 NBRP Rat No: 0493  Strain name: ACI.F344-(D16Nkg87-D16Nkg105)/Nkg  Commmon Name: Rat Genome Database
Principal Investigator:  Hitoshi Nakagama  National Cancer center        5-1-1 Tsukiji, Chuo-ku    104-0045 Tokyo     Japan
Tel: 03-3542-2511    Fax: 03-3542-2530 Email:
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  agouti
Inbred Generations  N9F3 (Jul 7, 2009)
Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). ACI.F344-(D16Rat64-D16Nkg105) (NBRP No.0492) was established by backcrossing ACI.F344-(D16Rat12-D16Mco2) onto ACI/N. This congenic strain was established by backcrossing ACI.F344-(D16Rat64-D16Nkg105) onto ACI/N, followed by intercrossing in N9 generation. maintained by crossing homozygous individuals. (Jul 7, 2009)
Strain characteristics ACF formation induced by feeding 2-weeks PhIP-containing diet and 4-weeks high-fat diet is higher in this congenic strain than that in ACI/N strain. (Jul 7, 2009)
Breeding Conditions
Additional strain information