Usage Restrictions
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Origin
F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). ACI.F344-(D16Rat64-D16Nkg105) (NBRP No.0492) was established by backcrossing ACI.F344-(D16Rat12-D16Mco2) onto ACI/N. This congenic strain was established by backcrossing ACI.F344-(D16Rat64-D16Nkg105) onto ACI/N, followed by intercrossing in N9 generation. maintained by crossing homozygous individuals. (Jul 7, 2009)
Strain characteristics
ACF formation induced by feeding 2-weeks PhIP-containing diet and 4-weeks high-fat diet is higher in this congenic strain than that in ACI/N strain. (Jul 7, 2009)