Gene Affected
Atp7b: ATPase, Cu++ transporting, beta polypeptide, Ptprk: protein tyrosine phosphatase, receptor type, K
Origin
Found in Long Evans strain at Kobe University > Inbreeding at Hokkaido University > Otsuka Pharmaceutical Co. > The University of Tokushima 1989
Strain characteristics
Hepatitis, jaundice, and a defect of T cell maturation.
Breeding Conditions
Good breeding performance. Sib mating.
References
Nakajima M, Kato J, Kohgo Y, Takeichi N, Niitsu T. Point mutation of aldehyde dehydrogenase-2 gene in mutant strains of Long-Evans rats. Alcohol Alcohol 29 Suppl 1:39-43, 1994
Kose H, Sakai T, Tsukumo S, Wei K, Yamada T, Yasutomo K, Matsumoto K.
Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats.
Genomics. 2007 Jun;89(6):673-7.
Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157