Strain information  NBRP Rat No: 0495  Strain name: KFRS4A/Kyo  Commmon Name: SRR04-A Rat Genome Database Principal Investigator:  Takashi Kuramoto  Tokyo University of Agriculture       1737 Funako, Atsugi,    243-0034 Kanagawa     Japan Tel: 046-270-6583    Fax: 046-270-6585 Email: tk206782@nodai.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  light brown Inbred Generations  F8 Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin A mutant rat was found in the course of inbreeding between a male rat (called TSR Louis) maintained by American breeders of fancy rats (Spoiled Ratten Rattery: SRR) and a PVG female. This rat showed gait abnormality in F3 and the abnormality became prominent in F5. F8 rats showed circling-like abnormality. KFRS is an abbreviation of Kyoto Fancy Rat SRR. (Jul 7, 2009) Strain characteristics Circling. Breeding Conditions Maintained by crossing of circling rats. Mutant females are fertile, but have failure of breast feeding, therefore, bad reproducibility. (Jul 7, 2009) Genotyping Determined by phenotype. References Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T. Genetic analyses of fancy rat-derived mutations. Exp Anim. 2010;59(2):147-55. Additional strain information