Strain information  NBRP Rat No: 0505  Strain name: ACI.BUF-(D7Wox16-D7Rat69)/Mna  Commmon Name: ACI/N-Tsr1/Tsr1 Rat Genome Database Principal Investigator:  Mutsushi Matsuyama  Fujita Health University        1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi    420-1192 Aichi     Japan Tel: 0562-93-2486    Fax: 0562-93-4008 Email: mmatsuya@fujita-hu.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  agouti Inbred Generations  N?F8 Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin The thymoma susceptible locus of rat-1, Tsr1 (on Chr 7) was transferred from BUF/Mna to ACI/NMs by repeated backcrossing. (Matsuyama, 2008) Strain characteristics About 75% F1 rats which generated by crossing ACI.BUF-(D7Wox16-D7Rat69)/Mna rats with ACI/NMs rats develop tymoma at 2 years of age. Breeding Conditions Sib mating. Genotyping References Matsuyama M, Kato K, Higo-Moriguchi K, Yamada T, Kuramoto T, Kuroda M. Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1. J Cancer Res Clin Oncol. 2008 134(7):789-92. Additional strain information