Strain information
 NBRP Rat No:   Strain name: EXHC/Ta  Commmon Name: ExHC/Ta, Exogenously hypercholesterolemic rat Rat Genome Database
Principal Investigator:  Yuji Iizawa  Takeda Chemical Industries, Ltd.        2-17-85, jusohonmati, yodogawa-ku    532－8686 Osaka     Japan
Tel: 06-6300-6868    Fax: 06-6300-6207 Email: Izawa_yuji@takeda.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ExHC_Ta/ExHC_TaA_1024.jpg ../images/Photos/ExHC_Ta/ExHC_TaZ_1024.jpg
Coat Color  albino(c)
Inbred Generations  F116 (Mar 2008)
Usage Restrictions   "USER" shall not utilize "THE RESOUCE (ExHC/Ta)" for research The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
aimed at discovering or validating drug candidates.
Should the results obtained from the use of "THE RESOURCE (ExHC/Ta)" be published or presented at meeting or symposia, "USER" shall send the manuscript to "DEPOSITOR" prior to submitting it for publication or presentation.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin EXHC rats were established from JcL:SD by repetitive inbreeding, in that a rat showing a higher serum total cholesterol was selected when fed 1% cholesterol-containing diet (Imai, 1973). (Jul 15, 2010)
Strain characteristics EXHC rats develop hypercholesterolemia for exogenous cholesterol without hypertriglyceridemia. (Imai, 1973; Imaizumi, 1992)
Significant QTLs for serum total cholesterol levels were mapped on rat chromosome 5 and 14 (Dihc1 and Dich2, respectively) (Asahina, 2005). SMEK2 was identified as a candidate gene for Dich2 (Asahina, 2009).
Fed a high cholesterol diet, EXHC rats develop proteinuria and characteristic glomerular lesion (Hattori, 1993; Miyazaki, 1997). (Jul 15, 2010)
Breeding Conditions
Genotyping
References Imai Y, Matsumura H.
Genetic studies on induced and spontaneous hypercholesterolemia in rats.
Atherosclerosis. 1973 Jul-Aug;18(1):59-64.

Imaizumi K, Nagatomi A, Sato M, Tominaga A, Sugano M.
Cholesterol metabolism in ExHC (exogenous hypercholesterolemic) rats.
Biochim Biophys Acta. 1992 Jan 3;1123(1):101-9.

Asahina M, Sato M, Imaizumi K.
Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.
J Lipid Res. 2005 Oct;46(10):2289-94.

Asahina M, Haruyama W, Ichida Y, Sakamoto M, Sato M, Imaizumi K.
Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.
J Lipid Res. 2009 Jan;50(1):41-6.

Hattori M, Yamaguchi Y, Kawaguchi H, Ito K.
Characteristic glomerular lesions in the ExHC rat: a unique model for lipid-induced glomerular injury.
Nephron. 1993;63(3):314-22.

Miyazaki K, Isbel NM, Lan HY, Hattori M, Ito K, Bacher M, Bucala R, Atkins RC, Nikolic-Paterson DJ.
Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat.
Clin Exp Immunol. 1997 May;108(2):318-23.
Additional strain information