Strain information
 NBRP Rat No: 0536  Strain name: CLX/Ta  Commmon Name: Circling behavior linked to the X-chromosome (CLX) Rat Genome Database
Principal Investigator:  Yuji Iizawa  Takeda Chemical Industries, Ltd.        2-17-85, jusohonmati, yodogawa-ku    532－8686 Osaka     Japan
Tel: 06-6300-6868    Fax: 06-6300-6207 Email: Izawa_yuji@takeda.co.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  F38 (Mar 2008)
Usage Restrictions  "USER" shall not utilize "THE RESOUCE (ExHC/Ta)" for research The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
aimed at discovering or validating drug candidates.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin A male rat showing circling behavior was found among the Jcl:Wistar rats at Takeda Chemical Industries, Ltd. in 1993 (Fuji, 2002). (May 28, 2010)
Strain characteristics Circling behavior phenotype is controlled by a single sex-linked recessive gene clx (circling behavior linked to X chromosome) (Fuji, 2002). The main behavioral features of the abnormal behavior rats are intermittent circling and head tossing with the neck twisted. CLX rats showed no nystagmus after rotating stimulation and the result of air righting reflex test and negative geotaxis test suggested that CLX rats may have some defect in vestibular function (Fuji, 2003). CLX rats showed hyperactivity in the open field test. (May 28, 2010)
Breeding Conditions Maintained by crossing sib mating between clx/Y males and clx/clx females. The circling behavior is not seem to influence the reproductive ability (Fuji, 2002). (May 28, 2010)
Genotyping
References Fuji J, Fukuda R, Imoto F, Ooshima Y.
New behavioral mutant rat exhibiting circling behavior (clx) controlled by a sex-linked recessive gene.
Congenit Anom (Kyoto). 42(3):187-93, 2002.

Fuji J, Tanabe H, Fukuda R, Ooshima Y.
Defective balancing ability and hyperactivity in the CLX (circling behavior linked to the X-chromosome) mutant rat.
Congenit Anom (Kyoto). 43(4):294-301, 2003.
Additional strain information