Strain information  NBRP Rat No: 0557  Strain name: LE.AR-EdnrbSl/Okkm  Commmon Name: LE.AR-sl Rat Genome Database Principal Investigator:  Tohru Kimura  National Institute for Physiological Sciences       38 Nishigo-naka, Myodaiji, Okazaki    444-8585 Aichi     Japan Tel: 0564-55-7882    Fax: 0564-55-7881 Email: kimura@nips.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  black hooded Inbred Generations  F10 (May 2008) Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Ednrb: endothelin receptor type B Origin AR rats (NBRP No.0556) were found a by Ikadai et al. at Institute for Animal Reproduction in 1973 (Ikadai, 1979). From 1997, backcross of AR rats onto Long Evans rats has started. After the 9th generation of backcrossing, it has been maintained by sib mating (F10 in May 2008). (Jul 7, 2009) Strain characteristics This congenic strain is characterized by megacolon and white coat color with a small pigmented spot on the head as shown in AR rat (Ikadai, 1979). This congenic strain usually dies within 1-5 weeks of age, but some individuals can survive, which suggest that a Long Evans gene might rescue their phenotype. (Jul 7, 2009) Breeding Conditions Homozygous sl rats die within 1-5 weeks of age. The sl mutation is maintained in heterozygous condition (closed colony). (Jul 7, 2009) Genotyping Genotyping protocol for Ednrb References Additional strain information AR (Aganglionosis rat)