Strain information
NBRP Rat No: 0548
Strain name
: BCR/Nn
Commmon Name: DR150-2
Rat Genome Database
Principal Investigator:
Nobuyuki Nukina RIKEN Brain Science Institute(RIKEN BSI) 2-1 Hirosawa Wako-city, Saitama 351-0198 Saitama Japan
Tel: 048-462-1111 内線7644 Fax: 048-462-4796
Email: nukina@brain.riken.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
albino (c)
Inbred Generations
F22 (Aug 2008)
Usage Restrictions
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
In the course of producing transgenic rats (DRPLA promoter + huntingtin exon1+EGFP on a Slc:SD background), a mutant rat showing involuntary movements (circling) and symptoms of dystonia was found in F6 progeny. Subsequent by the selection of the involuntary movement segregated the transgene from the phenotype. Thereafter this strain was maintained by only the phenotype (not the transgene). (Jul 7, 2009)
Strain characteristics
Involuntary movements and symptoms of dystonia appear after 4 weeks of age. These phenotypes have little effect on life span. (Jul 7, 2009)
Breeding Conditions
This strain is maintained by crossing heterozygous females (without involuntary movement) with homozygous males (with involuntary movement). Homozygous females have less performance of nursing behavior for their pups. Homozygous males are fertile until about 25 weeks of age. Sib mating. (Jul 7, 2009)
Genotyping
Determined by phenotype. (Jul 7, 2009)
References
Additional strain information