Strain information

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NBRP Rat No: 0061

Strain name: F344.OLETF-(D8Rat54-D8Mgh17)/Tj

Commmon Name: F.O-Nidd3/of

Rat Genome Database

Principal Investigator:

Kozo MatsumotoThe University of Tokushima Graduate School of Medicine

Preservation Status:

Embryo Sperm Living Animals

Coat Color

Inbred Generations

N(5)F10

Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must agree on collaborative research with the DEPOSITOR. Any form of publications of data resulting from the use of the BIOROGICAL RESOURCE require co-authorship. This condition is NOT limited to two-year period after deposition.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating.

Strain characteristics

This congenic strain is homozygous for the Nidd3/of allele (on chr. 8) on the F344/Slc background. OLETF is a model for type 2 diabetes and some QTLs responsible for non-insulin-dependent diabetes mellitus (NIDDM) including Nidd3/of were mapped (Kose, 2002). This congenic strain shows mild hyperglycemia in the OGTT assay. F1 progeny between this congenic strain and F344/Slc showed mild hyperglycemia, suggesting OLETF allele was dominant (Kose, 2008). (10.11.2)

Breeding Conditions

Good breeding performance.

Genotyping

References

Kose H, Moralejo DH, Ogino T, Mizuno A, Yamada T, Matsumoto K.
Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats.
Mamm Genome. 2002 Oct;13(10):558-62.

Kose H, Yamada T, Matsumoto K.
OLETF allele of hyperglycemic QTL Nidd3/of is dominant.
Exp Anim. 2008 Apr;57(2):135-8.

Additional strain information (Japanese only)

F.O