Strain information
 NBRP Rat No: 0061  Strain name: F344.OLETF-(D8Rat54-D8Mgh17)/Tj  Commmon Name: F.O-Nidd3/of Rat Genome Database
Principal Investigator:  Kozo Matsumoto  The University of Tokushima Graduate School of Medicine       3-18-15 Kuramoto-cho    770-8503 Tokushima     JAPAN
Tel: 088-633-9278    Fax: 088-600-9429 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  
Inbred Generations  N(5)F10
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must agree on collaborative research with the DEPOSITOR. Any form of publications of data resulting from the use of the BIOROGICAL RESOURCE require co-authorship. This condition is NOT limited to two-year period after deposition.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating.
Strain characteristics This congenic strain is homozygous for the Nidd3/of allele (on chr. 8) on the F344/Slc background. OLETF is a model for type 2 diabetes and some QTLs responsible for non-insulin-dependent diabetes mellitus (NIDDM) including Nidd3/of were mapped (Kose, 2002). This congenic strain shows mild hyperglycemia in the OGTT assay. F1 progeny between this congenic strain and F344/Slc showed mild hyperglycemia, suggesting OLETF allele was dominant (Kose, 2008). (10.11.2)
Breeding Conditions Good breeding performance.
References Kose H, Moralejo DH, Ogino T, Mizuno A, Yamada T, Matsumoto K.
Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats.
Mamm Genome. 2002 Oct;13(10):558-62.

Kose H, Yamada T, Matsumoto K.
OLETF allele of hyperglycemic QTL Nidd3/of is dominant.
Exp Anim. 2008 Apr;57(2):135-8.
Additional strain information F.O