Strain information  NBRP Rat No: 0572  Strain name: KFRS4/Kyo  Commmon Name: SRR04 Rat Genome Database Principal Investigator:  Takashi Kuramoto  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     Japan Tel: 075-753-4494    Fax: 075-753-4409 Email: kuramot@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  light brown Inbred Generations  F24 (April 2012) Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin One male rat "TSR Louis" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "TSR Louis" and a female PVG/Seac. (Sep 25, 2009) Strain characteristics This strain carries two mutations, head spot (hs) which causes white spotting on the head, and dumbo (dmbo) which causes abnormal ear morphology (Kuramoto, 2010). Ears are set lower on the head, and are larger and rounder. Genetic analyses mapped hs to Chr 15 and dmbo to Chr 14. A SINE insertion was identified in the exon 7 of Hermansky-Pudlak syndrome 5 (Hps5)gene (Kuramoto, 2010). (Jul 4, 2011) Breeding Conditions Good breeding performance. (Sep 25, 2009) Genotyping References Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M. A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo. BMC Genet. 2017 Mar 29;18(1):29. Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M. Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat. BMC Genomics. 2016 Aug 9;17:593. Kuramoto T, Yokoe M, Tanaka D, Yuri A, Nishitani A, Higuchi Y, Yoshimi K, Tanaka M, Kuwamura M, Hiai H, Kabashima K, Serikawa T. Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats. J Dermatol Sci. 2015 Nov;80(2):116-23. Quina L, Kuramoto T, Luquetti DV, Cox TC, Serikawa T, Turner EE. Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a novel cause of congenital ear malformation. Dis Model Mech. 2012 Nov;5(6):812-22. Watanabe K, Wada K, Ohashi T, Okubo S, Takekuma K, Hashizume R, Hayashi J, Serikawa T, Kuramoto T, Kikkawa Y. A 5-bp Insertion in Mip Causes Recessive Congenital Cataract in KFRS4/Kyo Rats. PLoS One, 2012, 7 (11), e50737. Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T. Genetic analyses of fancy rat-derived mutations. Exp Anim. 2010;59(2):147-55. Takashi Kuramoto, Satoshi Nakanishi, Ken-ichi Yamasaki, Kenta Kumafuji, Yuichi Sakakibara, Yuki Neoda, Akiko Takizawa, Takehito Kaneko, Mito Otsuki, Ryoko Hashimoto, Birger Voigt, Tomoji Mashimo and Tadao Serikawa Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat. ibc.2010 Volume 2 Article no. 0012 Additional strain information