| NBRP Rat No: 0573 |
Strain name: KFRS5A/Kyo |
Commmon Name: SRR05-Rex |
Rat Genome Database |
| Principal Investigator: |
Takashi Kuramoto Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto Japan |
| Tel: 075-753-4494 Fax: 075-753-4409 |
Email: kuramot@anim.med.kyoto-u.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
black hooded |
| Inbred Generations |
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| Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
One male rat "SRR Coming Home" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR Coming Home" and a female TM/Kyo. (Sep 25, 2009) |
| Strain characteristics |
The rat autosomal dominant Rex (Re) mutation on chromosome 7 causes curly hair in Re/+ and hair loss in Re/Re rats. Histopathologically, the Re/+ rat showed dilatation of the hair follicle and hairs with irregularly-coated cuticles, and the Re/Re rat showed more severe effects. Re is a 7-bp deletion at the splicing acceptor site of intron 1 of the keratin 71 (Krt71) gene. (Kuramoto, 2010) (Apr 20, 2010) |
| Breeding Conditions |
Maintained by crossing of heterozygous and homozygous for Rex gene. Good breeding performance. (Sep 25, 2009) |
| Genotyping |
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| References |
Kuramoto T, Hirano R, Kuwamura M, Serikawa T.
Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene.
J Vet Med Sci. 2010 Jul;72(7):909-12.
Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Genetic analyses of fancy rat-derived mutations.
Exp Anim. 2010;59(2):147-55. |
| Additional strain information |
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