Strain information  NBRP Rat No: 0374  Strain name: W-Tg(MT2A-Myc)2Ys  Commmon Name: Wistar-Tg(MT2A-Myc)2Ys, MT-myc Transgenic rat 2 Rat Genome Database Principal Investigator:  Masatsugu Ueda  PhoenixBio Co., Ltd.       1198-4, Iwaso, Utsunomiya    321-0973 Tochigi     Japan Tel: 028-683-1153    Fax: 028-664-2410 Email: ystg@phoenixbio.co.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  N? Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Myc: myelocytomatosis oncogene Origin Established at the YS Institute, Inc. (present: PhoenixBio Co., Ltd.). Strain characteristics This transgenic rat is expressing the rat c-myc gene under the control of the human metallothionein II A promoter. Male transgenic rats are sterile. Breeding Conditions Transgenic rats are maintained by backcorssing with Crlj:WI. Genotyping References Kodaira K, Takahashi R, Hirabayashi M, Suzuki T, Obinata M, Ueda M. Overexpression of c-myc induces apoptosis at the prophase of meiosis of rat primary spermatocytes. Mol Reprod Dev. 45(4):403-10, 1996. Hirabayashi M, Yoshizawa Y, Kato M, Tsuchiya T, Nagao S, Hochi S. Availability of subfertile transgenic rats expressing the c-myc gene as recipients for spermatogonial transplantation. Transgenic Res. Oct 1, 2008. Additional strain information