Strain information  NBRP Rat No: 0612  Strain name: WKY/Kiha  Commmon Name: HA-WKY Rat Genome Database Principal Investigator:  Hiroyuki Ito  Kinki University Faculty of Medicine        377-2, Ohnohigashi, Oosaka-sayama-shi    589-8511 Osaka     Japan Tel: 072-366-0221 (x3142)     Fax: 072-360-2028 Email: takao@med.kindai.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F32 (Apr 2010) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin In 1974, WKY strain was transferred Dr. Okamoto from Kyoto University to. In Department of Pathology, Kinki University School of Medicine, a rat showing higher serum adiponectin concentration was found (Inoue, 2010). (Aug 31, 2010) Strain characteristics WKY/Kiha (HA-WKY) rats exhibit about 4-fold higher serum adiponectin concentration at 6 weeks of age compared with that of WKY/Izm. When fed high-fat diets, WKY/Kiha rats show hyperinsulinemia and severe hypercholesterolemia. The lack of adiponectin binding to skeletal muscle seems to cause these phenotypes of WKY/Kiha (Inoue, 2010). (Aug 31, 2010) Breeding Conditions Sib mating. Genotyping No data. References Inoue T, Takemori K, Yamamoto K, Ito H. Characterization of Wistar-Kyoto rats showing hyperadiponectinemia. Life Sci. 2010 Feb 27;86(9-10):344-50. Additional strain information