Strain information

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NBRP Rat No: 0612

Strain name: WKY/Kiha

Commmon Name: HA-WKY

Rat Genome Database

Principal Investigator:

Hiroyuki ItoKinki University Faculty of Medicine

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

F32 (Apr 2010)

Usage Restrictions

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

In 1974, WKY strain was transferred Dr. Okamoto from Kyoto University to. In Department of Pathology, Kinki University School of Medicine, a rat showing higher serum adiponectin concentration was found (Inoue, 2010). (Aug 31, 2010)

Strain characteristics

WKY/Kiha (HA-WKY) rats exhibit about 4-fold higher serum adiponectin concentration at 6 weeks of age compared with that of WKY/Izm. When fed high-fat diets, WKY/Kiha rats show hyperinsulinemia and severe hypercholesterolemia. The lack of adiponectin binding to skeletal muscle seems to cause these phenotypes of WKY/Kiha (Inoue, 2010). (Aug 31, 2010)

Breeding Conditions

Sib mating.

Genotyping

No data.

References

Inoue T, Takemori K, Yamamoto K, Ito H.
Characterization of Wistar-Kyoto rats showing hyperadiponectinemia.
Life Sci. 2010 Feb 27;86(9-10):344-50.

Additional strain information (Japanese only)