Strain information

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NBRP Rat No: 0611　

Strain name: W-Tg(RNB1-116K03-EGFP,-mRFP)104Kyo

Commmon Name:

Rat Genome Database

Principal Investigator:

Takashi KuramotoTokyo University of Agriculture

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

N5 (Jun 2010)

Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Attractin-EGFP recombinant gene

Origin

The transgene consists of the bacterial artificial chromosome (BAC) clone RNB1-116, which contains the attractin (Atrn) gene which is modified by in-frame insertion of the EGFP reporter gene upstream of the 29th exon and an in-frame insersion of the mRFP reporter gene between 24th exon and stop codon. As of Jun 2010, 6 congenic strains are being developed (line 3, 20, 21, 22, 41 and 104). (Nov 25, 2010)

Strain characteristics

Phenotype not completely analyzed yet. In this transgenic rat, it is expected that the membrane form of attractin is co-expressesed with EGFP (green fluorescent protein) as recombinant protein and the secreted form of attractin expresses mRFP1 (red fluorescent protein) recombinant protein. (Nov 25, 2010)

Breeding Conditions

Maintained by crossing of Tg hemizygous and F344/NSlc. (Nov 25, 2010)

Genotyping

References

Additional strain information (Japanese only)