Strain information
 NBRP Rat No: 0599  Strain name: SD-Tg(Eno2-ATXN3*64Q)29Kakiz  Commmon Name: NSE-Q64C(L29) Rat Genome Database
Principal Investigator:  Akira Kakizuka (Hori Seiji)  Graduate School of BIOSTUDIES, Kyoto University       Yoshidakonoe-cho, Sakyo-ku, Kyoto    606-8501 Kyoto     Japan
Tel: 075-753-7677    Fax: 075-753-7676 Email: shori@lif.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  albino (c)
Inbred Generations  10 (Oct 2009)
Usage Restrictions  The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent indicating the extent of experimental use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the DEPOSITOR and the RECIPIENT.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Eno2: enolase 2, gamma, neuronal; ATXN3: ataxin 3
Origin Background strain is Slc:SD. Please refer to SD-Tg(Eno2-ATXN3*64Q)16Kakiz (NBRP No.0598). (Jun 22, 2010)
Strain characteristics This transgenic strain contains human ATXN3 (MJD1, polyQ repeat 64) gene fragment driven by rat Eno2 (NSE: neuron specific enolase) promoter. Transgene ATXN3*64Q is the construct containing of C-terminal part and polyglutamine part of human ATXN3, but not of N-terminal part. Aggregation of ATXN3*64Q polygultamine leads to ataxia. Line 16 is more likely to develop ataxia than Line 29. (Jun 22, 2010)
Breeding Conditions Maintained by crossing between Tg hemizygous and wild rats. (Jun 22, 2010)
Genotyping Genotyping by PCR analysis.
References in preparation
Additional strain information