Strain information  NBRP Rat No: 0598  Strain name: SD-Tg(Eno2-ATXN3*64Q)16Kakiz  Commmon Name: NSE-Q64C(L16) Rat Genome Database Principal Investigator:  Akira Kakizuka (Hori Seiji)  Graduate School of BIOSTUDIES, Kyoto University       Yoshidakonoe-cho, Sakyo-ku, Kyoto    606-8501 Kyoto     Japan Tel: 075-753-7677    Fax: 075-753-7676 Email: shori@lif.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color   Inbred Generations  12 (Oct 2010) Usage Restrictions  The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent indicating the extent of experimental use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the DEPOSITOR and the RECIPIENT. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Eno2: enolase 2, gamma, neuronal; ATXN3: ataxin 3 Origin Background strain is Slc:SD. Please refer to SD-Tg(Eno2-ATXN3*64Q)29Kakiz (NBRP No. 0599). (Jun 22, 2010) Strain characteristics This transgenic strain contains human ATXN3 (MJD1, polyQ repeat 64) gene fragment driven by rat Eno2 (NSE: neuron specific enolase) promoter. Transgene ATXN3*64Q is the construct containing of C-terminal part and polyglutamine part of human ATXN3, but not of N-terminal part. Aggregation of ATXN3*64Q polygultamine leads to ataxia. Line 16 is more likely to develop ataxia than Line 29. (Jun 22, 2010) Breeding Conditions Maintained by crossing between Tg hemizygous and wild rats. (Jun 22, 2010) Genotyping Genotyping by PCR analysis. References in preparation Additional strain information