Strain information
 NBRP Rat No: 0603  Strain name: W-Tg(Gh1as)Nibs  Commmon Name: ミニラット　Nts:Mini rat Rat Genome Database
Principal Investigator:  Tetsuo Nunoya   Nippon Institute for Biological Science        9-2221-1, Shinmachi, Ome    198-0024 Tokyo     Japan
Tel: 0428-33-1056     Fax: 0428-33-1036 Email: s-nobuko@nibs.or.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  F46 (May 2010)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. This rat will be made available subject to the following conditions. 1. The rat is to be used either by a)scientists affiliated with a non-profit research institution who are engaged in academic research. or b)commercial or similar interests, they need a secured written agreement from Nippon Institute for Biological Science (NIBS). 2. The rat never be distributed to third parties. 3. If the rat is referred to in any publication, then correct reference will be made to NIBS. 4. NIBS does not accept any liability whatever in connect with the handling or use of the rat.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 小型なため長期飼育試験に有用
 Control Strain  Marker Strain
Gene Affected antisense strand for rat Gh1
Origin The construct which contains of rat growth hormone (Gh1) promoter, 4 copies of thyroid hormone response element (TRE), and antisense sequences for rat Gh1 cDNA was injected into Jcl:Wistar embryo (Matsumoto, 1993). This transgenic rat was established at NT Science in 1992, and transferred to Japan Bio Science Laboratory Co., Ltd. in 2003. This strain has been maintained at Nagasaki University Graduate School of Biomedical Science. This strain is one of the Tg lines described as “TRE4 910329-32” in the reference 1 (Matsumoto, 1993). (Jun 21, 2010)
Strain characteristics This rat expresses an antisense RNA for inhibiting Gh1 expression in the pituitary and exhibits dwarfism. Plasma GH concentration was lower in both hemizygous and homozygous transgenic rats (Matsumoto, 1995). This transgenic rat can be an animal model for human growth hormone deficiency. (Jun 21, 2010)
Breeding Conditions Both hemizygous and homozygous rats have fertility.
Genotyping RT-PCR
References Matsumoto K, Kakidani H, Takahashi A, Nakagata N, Anzai M, Matsuzaki Y, Takahashi Y, Miyata K, Utsumi K, Iritani A.
Growth retardation in rats whose growth hormone gene expression was suppressed by antisense RNA transgene.
Mol Reprod Dev. 1993 Sep;36(1):53-8.
Additional strain information