Strain information  NBRP Rat No: 0633  Strain name: W.GR-Ugt1a1j/Aon  Commmon Name: WGR Rat Genome Database Principal Investigator:   Sachiko Aono  Aichi Human Service Center       713-8 Kagiyacho, Kasugai    480-0392 Aichi     JAPAN Tel: 0568-88-0811    Fax: 0568-88-0829 Email: saono@inst-hsc.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  白 Inbred Generations  SDGR：F73、WGR：F22 Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Ugt1a1: UDP glucuronosyltransferase 1 family, polypeptide A1 Origin After SDGR rats were backcrossed with Wistar rats ten times, This strains were established. Strain characteristics WGR strains having a 1 base deletion in Ugt1a1 show hyperbilirubinemia. WGR are better reproductive peformance than SDGR. Breeding Conditions Genotyping References Sato, H., Aono, S., Kashiwamata, S. and Koiwai, O. (1991) Genetic defect of bilirubin UDP-glucuronosyltransferase in the　hyperbilirubinemic Gunn rat. Biochem. Biophys. Res. Commujn., 177, 1161-1164. Keino, H., Sato, H., Semba, R., Aono, S., Aoki, E., and Kashiwamata, S. (1985-86) Mode of prevention by phototherapy of cerebellar hypoplasia in a new Sprague-Dawley strain of jaundiced Gunn rats. Peidat. Neurosci., 12, 145-150. Additional strain information