Strain information

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NBRP Rat No: 0633

Strain name: W.GR-Ugt1a1^j/Aon

Commmon Name: WGR

Rat Genome Database

Principal Investigator:

Sachiko AonoAichi Human Service Center

Preservation Status:

Embryo Sperm Living Animals

Coat Color

白

Inbred Generations

SDGR：F73、WGR：F22

Usage Restrictions

In publishing, an acknowledgment to the DEPOSITOR is requested.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Ugt1a1: UDP glucuronosyltransferase 1 family, polypeptide A1

Origin

After SDGR rats were backcrossed with Wistar rats ten times, This strains were established.

Strain characteristics

WGR strains having a 1 base deletion in Ugt1a1 show hyperbilirubinemia. WGR are better reproductive peformance than SDGR.

Breeding Conditions

Genotyping

References

Sato, H., Aono, S., Kashiwamata, S. and Koiwai, O. (1991) Genetic defect of bilirubin UDP-glucuronosyltransferase in the　hyperbilirubinemic Gunn rat. Biochem. Biophys. Res. Commujn., 177, 1161-1164.

Keino, H., Sato, H., Semba, R., Aono, S., Aoki, E., and Kashiwamata, S. (1985-86) Mode of prevention by phototherapy of cerebellar hypoplasia in a new Sprague-Dawley strain of jaundiced Gunn rats. Peidat. Neurosci., 12, 145-150.

Additional strain information (Japanese only)