Strain information
 NBRP Rat No: 0651  Strain name: WIAR.MPR-Arsbabd/Ncchd  Commmon Name: MPR Rat Genome Database
Principal Investigator:  XIAO-KANG LI  National Research Institute for Child Health and Development       2-10-1, Okura, Setagaya-ku,     157-8535 Tokyo     JAPAN
Tel: 03-5494-8283    Fax: 03-415-2171 Email:
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  白
Inbred Generations  
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Arsb: arylsulfatase B
Origin This congenic strain was established by backcrossing MPR/Iar (provided by Dr. Kunieda, Okayama University) to WIAR/Iar
Strain characteristics This strain does not show organ rejection reaction after organ transplantation.
Under analysis for detailed phenotype.
Breeding Conditions Maintained as segregating inbred strain (Arsb is heterozygous). Arsb-homozygous rats (both male and female) are unsuitable for breeding.
Genotyping Sequence analysis to detect one-base insertion of C, resulting in right contiguous "C" from nucleotide 664 in the exon3.
PCR condition:80℃ 15min, 94℃ 5min, (94℃0.5min,60℃ 1min,72℃ 1min)×35cycle, 72℃ 7min.
References Yoshida M, Noguchi J, Ikadai H, Takahashi M, Nagase S.
Arylsulfatase B-deficient mucopolysaccharidosis in rats.
J Clin Invest. 91(3):1099-104, 1993.

Kunieda T, Simonaro CM, Yoshida M, Ikadai H, Levan G, Desnick RJ, Schuchman EH.
Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation.
Genomics. 10;29(3):582-7, 1995.

Toyama S, Migita O, Fujino M, Kunieda T, Kosuga M, Fukuhara Y, Nagahara Y, Li XK, Okuyama T.
Liver transplantation: New treatment for mucopolysaccharidosis type VI in rats.
Pediatr Int. 2019 Feb;61(2):180-189. doi: 10.1111/ped.13751. Epub 2019 Feb 21.
Additional strain information