Strain information
 NBRP Rat No: 0625  Strain name: KDP.PVG-RT1a/u/Nyo  Commmon Name: KDP.PVG-RT1a/u congenic, KP congenic Rat Genome Database
Principal Investigator:  Norihide Yokoi  Kobe University Graduate School of Medicine       Kobe BT Center, 1-5-6, Minatojima Minami-cho, Chuo-ku, Kobe    650-0047 Hyogo     Ｊａｐａｎ
Tel: 078-304-6046    Fax: 078-304-6057 Email: yokoi@med.kobe-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  black hooded (a,B,C,h)
Inbred Generations  N12F6 (2010.9.1)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.The recipients shall cite the references of the resource and acknowledge the depositor as the source of the resource in the publications. Depending on the project of the recipients, a collaborative arrangement with the depositor could be required. In this case, the recipients shall discuss with the depositor.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected MHC haplotype （RT1.Ba/uDa/u）
Origin MHC haplotype (RT1.BaDa) of PVG.R23 was transferred onto the genetic background of KDP/TKy strain (RT1.BuDu). This allele has been maintained in heterozygous condition. Backcrossing has started since 2003 and afterwards maintained by sib mating (N12F6). (Nov 25, 2010)
Strain characteristics The rats homozygous for the RT1u/u develop diabetes frequently similar to that of KDP rats (RT1u/u). RT1a/u heterozygous rats develops diabetes with low frequency. RT1a/a homozygous rats do not develop diabetes. Both RT1a/u and RT1a/a rats exhibit thyroidititis. (Nov 25, 2010)
Breeding Conditions Maintained by crossing between heterozygotes of the MCH and Cblb locus. (Nov 25, 2010)
Genotyping Genotyping by PCR-RFLP for MCH and Cblb.
References Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y.
Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats.
Endocr J. 1998 Dec;45(6):737-44.

Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 2002 Aug;31(4):391-4.

Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K.
Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain.
Exp Anim. 2003 Jul;52(4):295-301
Additional strain information