Strain information
 NBRP Rat No: 0627  Strain name: F344-Atmm1Kyo  Commmon Name: Atm missense Rat Genome Database
Principal Investigator:  Tomoji Mashimo  The University of Tokyo, The Institute of Medical Science       4-6-1 Shirokanedai-Minatoku-Tokyoto    108-8639      Japan
Tel: 03-6409-2489    Fax:  Email:
Preservation Status:   Embryo        Sperm       Living Animals ?s_Immunology=1 ?s_Immunology=1
Coat Color  albino (c)
Inbred Generations  N4 (April 2012)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Atm: Ataxia telangiectasia mutated
Origin This strain is an Atm missense mutant (amino acid change of leucine (L) to proline (P) at position 2262 (L2262P))rat and was established by ENU mutagenesis using F344/NSlc strain.
Strain characteristics Ataxia-telangiectasia (A-T) model rat: Atm-mutant rats expressed low levels of ATM protein and had a significantly reduced lifespan compared with Atm+/+. Whereas these rats did not show cerebellar atrophy, they succumbed to hind-limb paralysis (45%), and the remainder developed tumors. Closer examination revealed the presence of both dsDNA and ssDNA in the cytoplasm of both neurons and glia in the hippocampus, cerebellum, and spinal cord of AtmL2262P/L2262P rats. Other detailed phenotypes are described in the reference article. (March 2017)
Breeding Conditions Maintained in heterozygous condition
Genotyping Genotyping protocol for Atm
References Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.
Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.
J Leukoc Biol. 2016 Nov 28. pii: jlb.4VMA0716-316R.
Additional strain information