Strain information
 NBRP Rat No: 0628  Strain name: F344-Lepm1Kyo  Commmon Name: F344 OB rat Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino (c)
Inbred Generations  N10 (April 2012)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lep: Leptin
Origin Established by gene-driven ENU mutagenesis (F344/NSlc). this strain has nonsense mutation （Q92X）in the Lep gene.
Strain characteristics This strain shows obesity.
Breeding Conditions backcrossing to F344/NSlc
Genotyping Genotyping protocol for Lep
References Aizawa-Abe M, Ebihara K, Ebihara C, Mashimo T, Takizawa A, Tomita T, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K.
Generation of leptin deficient Lepmkyo/Lepmkyo rats and identification of leptin responsive genes in the liver.
Physiol Genomics. 2013 Sep 3;45(17):786-93.

Aizawa-Abe M, Ebihara K, Mashimo T, Kusakabe T, Yamamoto Y, Miyamoto L, Miyawzawa T, Aotani D, Yamamoto-Kataoka S, Sakai T, Ebihara C, Iogawa H, Hosoda K, Serikawa T, Nakao K.
Generation of a genetically obese leptin deficient rat The XVIIIth International Workshop on Genetic Systems in the Rat, Abstract p100, Nov30-Dec3, 2010, Kyoto, Japan.

海老原 健、阿部 恵、真下 知士、海老原 千尋、Valentino Gumbirai, 日下部 徹、細田 公則、芹川 忠夫、中尾 一和
遺伝子改変ラットの解析とトランスレーショナルサイエンス
第47回高血圧関連疾患モデル学会学術総会抄録集, p28, 2011年9月6日, 札幌

Additional strain information