Strain information
 NBRP Rat No: 0635  Strain name: SD-Tg(Pbsn-TAg)1Obs  Commmon Name: SV40ラット、TRAPラット Rat Genome Database
Principal Investigator:  Tomoyuki Shirai  Nagoya City University Graduate School of Medical Sciences            467-8601 Nagoya     Japan
Tel: 052-853-8156    Fax: 052-842-0817 Email: sattak@med.nagoya-cu.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino
Inbred Generations  
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested. (see references)
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected ・SV40 Large T Antigen領域(No.5146-2676) ・Rat probasin promoter
Origin This transgenic strain was generated by microinjection into Jcl:SD fertilized eggs and carries SV40 Large T Antigen drived by Rat probasin promoter.
Strain characteristics This male Tg rats develop prostate cancer.
Breeding Conditions Tg female ×Jcl:SD male
Genotyping
References 1.　Asamoto, M., et al., Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Cancer Res, 2001. 61(12): p. 4693-700.
2.　Asamoto, M., et al., Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression 　　　　　　　　　　　　　 under probasin gene promoter control. Carcinogenesis, 2002. 23(3): p. 463-7.
3.　Cho, Y.M., et al., Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment. Cancer Sci, 2003. 94(2): p. 153-7.
4.　Cho, Y.M., et al., Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Prostate Cancer Prostatic Dis, 2007.
5.　Hokaiwado, N., et al., Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 2003. 94(12): p. 1042-5.
6.　Kandori, H., et al., Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 2005. 96(4): p. 221-6.
7.　Said, M.M., et al., Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist. Cancer Sci, 2006. 97(6): p. 459-67.
8.　Tang, M., et al., Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Cancer Sci, 2007. 98(4): p. 471-7.
Additional strain information