Strain information  NBRP Rat No: 0078  Strain name: DRH/Seac  Commmon Name: Rat Genome Database Principal Investigator:  竹内正紀         セアック吉冨株式会社        〒871-8550  福岡県 築上郡吉富町大字小祝955番地       日本 Tel: 0979-22-9577    Fax: 0979-24-1955 Email: Takeuchi.Masaki@me.m-pharma.co.jp Preservation Status:   Embryo            Sperm           Living Animals Coat Color  albino (c) Inbred Generations  F41+?+33(March 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin 1981年大阪大学にてDonryuラットより分離。Donryuラットを発癌物質3'-メチル-4-ジメチルアミノアゾベンゼン（3'-Me-DAB）を含む飼料で飼育し、発癌物質抵抗性を示したラットを選抜して20代以上兄妹交配を行い、確立した。1991年セアック吉冨㈱にて継代。 Strain characteristics 発癌抵抗性。DRHラットの3'-Me-DAB抵抗性に関するQTLが第1、4染色体上にマッピングされている。 Breeding Conditions Genotyping 生化学的遺伝子検査と免疫学的遺伝子検査 References Higashi K, Denda A, Higashi T, Hiai H. Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain. Comparative Medicine 54(4):373-377, 2004. Liu H, Higashi K, Hiai H. Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain. Cancer Sci. 2005 Mar;96(3):164-9. Hiai H, Liu H, Omi N, Tanuma J, Higashi K. DRH strain rats: Genetic resistance to chemical hepatocarcinogenesis. Trends in Cancer Research 2: 127-134, 2006. Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H. AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1. Additional strain information DRH