| NBRP Rat No: 0001 |
系統名: ACI/NKyo |
通称: August Copenhagen Irish |
Rat Genome Database |
| 研究責任者: |
芹川忠夫 京都大学大学院医学研究科 〒606-8501 京都府 京都市左京区吉田近衛町 日本 |
| Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
| 保存状況： |
胚 精子 生体 |
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| 毛色 |
agouti (A,B,hi) |
| 近交世代数 |
F143+73 (March 2012) |
| 利用条件 |
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| 分類 |
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| コマーシャルブリーダー |
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| 研究分野 |
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| 遺伝子 |
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| 由来 |
1988年NIHよりF143で京都大学医学部附属動物実験施設に導入。
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| 特性など |
約10～20％のACIラットで片側性の腎無形成、形成不全もしくは嚢胞性水腎症が出現する。発症個体はメスでは同側の子宮角の欠損、オスでは精巣の欠損または形成不全を伴う。 |
| 繁殖・維持方法 |
兄妹交配。繁殖成績良好だが、まれに片側子宮角欠損により産仔数が少なくなる。 |
| 遺伝診断法 |
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| 参考文献 |
Sung SY, Lin YW, Wu CC, Lin CY, Hsu PS, Periasamy S, Nagarajan B, Hsieh DJ, Tsai YT, Tsai CS, Lin FY.
Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats.
Biomater Sci. 2023 Mar 28;11(7):2566-2580.
Lin YW, Tsai CS, Huang CY, Tsai YT, Shih CM, Lin SJ, Li CY, Lin CY, Sung SY, Lin FY.
Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy.
Biomedicines. 2022 May 7;10(5):1089.
Lin FY, Shih CM, Huang CY, Tsai YT, Loh SH, Li CY, Lin CY, Lin YW, Tsai CS.
Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats.
Cardiovasc Drugs Ther. 2021 Dec;35(6):1111-1127.
Ueta H, Xu XD, Yu B, Kitazawa Y, Yu E, Hara Y, Morita-Nakagawa M, Zhou S, Sawanobori Y, Ueha S, Rokutan K, Tanaka T, Tokuda N, Matsushima K, Matsuno K.
Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells.
Int Immunol. 2021 Apr 22;33(5):261-272.
Ara S, Miyazaki A, Hoang Trung H, Yokoe M, Nakagawa Y, Kaneko T, Kuramoto T.
Long terminal repeat insertion in Kit causes unilateral renal agenesis in rats.
Translat Regulat Sci. 2(1): 30–35, 2020
Kitazawa Y, Ueta H, Sawanobori Y, Katakai T, Yoneyama H, Ueha S, Matsushima K, Tokuda N, Matsuno K.
Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes.
Front Immunol. 2019 May 29:10:1195.
Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.
Int Immunol. 2018 Jan 18. [Epub ahead of print]
Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.
Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T.
A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.
BMC Genetics 12:91, 2011
Matsuno K, Ueta H, Shu Z, Xue-Dong X, Sawanobori Y, Kitazawa Y, Bin Y, Yamashita M, Shi C.
The microstructure of secondary lymphoid organs that support immune cell trafficking.
Arch Histol Cytol. 2010;73(1):1-21. Review.
LinksShull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA.
Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.
Mamm Genome. 17(7):751-9, 2006. |
| 系統情報 |
ACI |
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