Strain information
 NBRP Rat No: 0572  Strain name: KFRS4/Kyo  Commmon Name: SRR04 Rat Genome Database
Principal Investigator:  庫本高志         京都大学大学院医学研究科        〒606-8501  京都府 京都市左京区吉田近衛町       日本
Tel: 075-753-4494    Fax: 075-753-4409 Email: kuramot@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo            Sperm           Living Animals ../images/Photos/KFRS4_Kyo_dumbo/2211-1a.jpg ../images/Photos/KFRS4_Kyo_dumbo/2211a.jpg
Coat Color  light brown
Inbred Generations  F24 (April 2012)
Usage Restrictions  利用者は事前に寄託者の提供承諾書を得ること。
商用に使用する際には、本同意書とは別に、寄託者と契約を結ばねばならない。
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin 2005年7月13日、米国ミズーリ州カンザスシティーのファンシーラットコロニー(Spoiled Ratten Rattery)より導入された雄ラットTSR LouisとPVG/SeacとのF1から近交系化を行う。
Strain characteristics 頭部の白斑変異をもたらすhead spot（hs）変異、耳介の形態異常をもたらすdumbo（dmbo）変異、淡毛色をもたらすamerican mink（am）変異をもつ（Kuramoto, 2010）。耳は大きく頭の低い位置に付いている。遺伝解析によって、hsは第15番染色体上、dmboは第14番染色体上、amは第1番染色体上にマッピングされた。Am変異はHermansky-Pudlak syndrome 5 (Hps5)遺伝子エクソン７内のSINE配列の挿入である (Kuramoto, 2010)。（Jul 4, 2011）
Breeding Conditions 繁殖性よい。
Genotyping
References Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo.
BMC Genet. 2017 Mar 29;18(1):29.

Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M.
Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.
BMC Genomics. 2016 Aug 9;17:593.

Kuramoto T, Yokoe M, Tanaka D, Yuri A, Nishitani A, Higuchi Y, Yoshimi K, Tanaka M, Kuwamura M, Hiai H, Kabashima K, Serikawa T.
Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats.
J Dermatol Sci. 2015 Nov;80(2):116-23.


Quina L, Kuramoto T, Luquetti DV, Cox TC, Serikawa T, Turner EE.
Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a novel cause of congenital ear malformation.
Dis Model Mech. 2012 Nov;5(6):812-22.

Watanabe K, Wada K, Ohashi T, Okubo S, Takekuma K, Hashizume R, Hayashi J, Serikawa T, Kuramoto T, Kikkawa Y.
A 5-bp Insertion in Mip Causes Recessive Congenital Cataract in KFRS4/Kyo Rats.
PLoS One, 2012, 7 (11), e50737.

Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Genetic analyses of fancy rat-derived mutations.
Exp Anim. 2010;59(2):147-55.

Takashi Kuramoto, Satoshi Nakanishi, Ken-ichi Yamasaki, Kenta Kumafuji, Yuichi Sakakibara, Yuki Neoda, Akiko Takizawa, Takehito Kaneko, Mito Otsuki, Ryoko Hashimoto, Birger Voigt, Tomoji Mashimo and Tadao Serikawa
Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat.
ibc.2010 Volume 2 Article no. 0012


Additional strain information