Japanese
 NBRP Rat No: 0661 Strain Name: A5M/Khos Commmon Name: AQP5変異ラット（AQP5-mutant rat）
 Principal Investigator  Kazuo Hosoi
 Organization   University of Tokushima Graduate School Institute of Health Biosciences,
 Address  3-18-15 Kuramoto-Cho

770-8504 Tokushima-shi

  Japan
 Telephone  088-633-7323  Fax:  088-633-7324  khosoi@tokushima-u.ac.jp
 Inbred Generations   F36（H24年1月20日現在） 
   
 Coat Color
 Deposition Status
 
 白
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Murdiastuti,K., N.N.Purwanti, M.R.Karabasil, X.Li, C.Yao, T.Akamatsu, N.Kanamori, and K.Hosoi, "A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands", American Journal of Physiology-Gastrointestinal and Liverand Liver Physiology, 291(6), G1081-G1088, 2006, December. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene ラット aquaporin 5
 Origin This mutant strain was detected by the existence of a point mutation at 308 (G308A) in the aquaporin 5 (AQP5) gene in Sprague-Dawley rat colony.
 
 Strain Characteristics The rats having this mutation show extremely low membrane expression of AQP5 in the SMG acinar cells and decreased water secretion from their salivary glands.
 
 Breeding Conditions Sib mating
 
 Genotyping  
 References  Karabasil, M.R., T. Hasegawa, A. Azlina, N. Purwanti, C. Yao, T. Akamatsu, S. Tomioka, and K. Hosoi, "Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking, and cellular localization in the submandibular gland of rats," Biology of the Cell, 103(2), 69-86, 2011

Beitz, E. edition, “Aquaporins” in Handbook of Experimental Pharmacology, 190, (Editor in Chief, F. Hofmann), Springer-Verlag, Berlin, 2009

Murdiastuti,K., N.Purwanti, M.R.Karabasil, X.Li, C.Yao, T.Akamatsu, N.Kanamori, and K.Hosoi, "A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands", American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(6), G1081-G1088, 2006

Murdiastuti,K., O.Miki, C.Yao, M.N. Parvin, C.Kosugi-Tanaka, T.Akamatsu, N.Kanamori, and K.Hosoi, "Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats", Pflugers Archives- European Journal of Physiology, 445(3), 405-412, 2002