Japanese
 NBRP Rat No: 0141 Strain NameDDI/Ddia Commmon Name: dokkyo diabetes insipidus rat, M520, 尿崩症ラット
 Principal Investigator  Sadao Yamaoka
 Organization   Dokkyo University, School of Medicine Department of Physiology, Laboratory of Cell Physiology and Neuroendocrinology
 Address  880, Kitakobayashi, Mibu, Shimotsuga

321-0293 Tochigi

 Japan
 Telephone  0282-87-2125  Fax:  0282-87-2125  yamaoka@dokkyomed.ac.jp
 Inbred Generations   F35 (Jun 2010) 
   
 Coat Color
 Deposition Status
 
 
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene arginine vasopressin (Avp)
 Origin  
 Strain Characteristics Homozygous 1bp deletion in Arginine vasopression gene.
Large amount of urine. 
 Breeding Conditions Because of large amount of urine, frequent change of bedding material is necessary. 
 Genotyping  
 References  Mechaly I, Macari F, Lautier C, Serrano JJ, Cros G, Grigorescu F.
Identification and sequence analysis of arginine vasopressin mRNA in normal and Brattleboro rat aortic tissue.
Eur J Endocrinol. 1998 Jul;139(1):123-6.

Schmale H, Richter D.
Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.
Nature. 1984 Apr 19-25;308(5961):705-9.