Japanese
 NBRP Rat No: 0298 Strain Name: LEW-Tg(Gt(ROSA)26Sor-lacZ)44Jmsk Commmon Name: LEW-<i>Tg(Rosa-LacZ)44Jmsk</i>, Rosa-lacZ44
 Principal Investigator  Eiji Kobayashi
 Organization   Center for Molecular Medicine, Jichi Medical School Division of Organ Replacement Research
 Address  3311-1, Yakushiji, Shimono-shi, Tochigi

329-0498 Tochigi

  Japan
 Telephone  0285-58-7446  Fax:  0285-44-5365  eijikoba@jichi.ac.jp
 Inbred Generations   F?+46 (April 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, the references designated by the DEPOSITOR are requested to be cited. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene lacZ: beta-galactosidase, E. coli
 Origin This strain was established at Jichi Medical School. This transgenic rat was originated from LEW (RT1<sup>l</sup>) strain purchased from Charles River Japan. 
 Strain Characteristics This strain expresses LacZ ubiquitously driven by the gene trap ROSA26 promoter.  
 Breeding Conditions Good breeding performance. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/modified LacZ_en.pdf">Genotyping protocol for modified LacZ</a>
 
 References  Kodama A, Kamei N, Kamei G, Kongcharoensombat W, Ohkawa S, Nakabayashi A, Ochi M.
In vivo bioluminescence imaging of transplanted bone marrow mesenchymal stromal cells using a magnetic delivery system in a rat fracture model.
J Bone Joint Surg Br. 2012 Jul;94(7):998-1006.

Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
Transplantation of Engineered Chimeric Liver With Autologous Hepatocytes and Xenobiotic Scaffold.
Ann Surg. 2013 Mar;257(3):542-7.

Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, Imai K, Shinomura Y.
Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat.
J Gastroenterol. 2011 Feb;46(2):143-52.

Inoue H, Ohsawa I, Murakami T, Kimura A, Hakamata Y, Sato Y, Kaneko T, Takahashi M, Okada T, Ozawa K, Francis J, Leone P, Kobayashi E.
Development of new inbred transgenic strains of rats with LacZ or GFP.
Biochem Biophys Res Commun. 2005 Apr 1;329(1):288-95.