NBRP Rat No: 0299 Strain NameLEW-Tg(Gt(ROSA)26Sor-luc)11Jmsk Commmon Name: LEW-<i>Tg(Rosa-luc)11Jmsk</i>,&nbsp;Luc11
 Principal Investigator  Eiji Kobayashi
 Organization   Center for Molecular Medicine, Jichi Medical School Division of Organ Replacement Research
 Address  3311-1, Yakushiji, Shimono-shi, Tochigi

329-0498 Tochigi

 Telephone  0285-58-7446  Fax:  0285-44-5365  eijikoba@jichi.ac.jp
 Inbred Generations   F11(March 2012) 
 Coat Color
 Deposition Status
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, the references designated by the DEPOSITOR are requested to be cited. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene luc: luciferase, firefly
 Origin This strain was established at Jichi Medical School. This transgenic rat was originated from LEW (RT1<sup>l</sup>) strain purchased from Charles River Japan. 
 Strain Characteristics This strain expresses luciferase driven by the gene trap ROSA 26 promoter.  
 Breeding Conditions Good breeding performance. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Luc_en.pdf">Genotyping protocol for Luc</a> 
 References  G&aacute;lisov&aacute; A, F&aacute;bryov&aacute; E, Sticov&aacute; E, Kosinov&aacute; L, Jir&aacute;tov&aacute; M, Herynek V, Berkov&aacute; Z, K&#345;&iacute;&#382; J, H&aacute;jek M, Jir&aacute;k D.
The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging.
Contrast Media Mol Imaging. 2017 Dec 26;2017:5418495

G&aacute;lisov&aacute; A, F&aacute;bryov&aacute; E, Jir&aacute;k D, Sticov&aacute; E, Lodererov&aacute; A, Herynek V, K&#345;&iacute;&#382; J, H&aacute;jek M.
Multimodal Imaging Reveals Improvement of Blood Supply to an Artificial Cell Transplant Site Induced by Bioluminescent Mesenchymal Stem Cells.
Mol Imaging Biol. 2017 Feb;19(1):15-23.

Nakabayashi A, Kamei N, Sunagawa T, Suzuki O, Ohkawa S, Kodama A, Kamei G, Ochi M.
In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model.
J Orthop Res.&nbsp;2013 May;31(5):754-9.

Kodama A, Kamei N, Kamei G, Kongcharoensombat W, Ohkawa S, Nakabayashi A, Ochi M.
In vivo bioluminescence imaging of transplanted bone marrow mesenchymal stromal cells using a magnetic delivery system in a rat fracture model.
J Bone Joint Surg Br. 2012 Jul;94(7):998-1006.

Hata T, Iwasaki J, Hishikawa S, Fujimoto Y, Uemoto S, Kobayashi E.
Development of a portocaval shunt using a small intestinal segment in rats.
Microsurgery. 2010 May;30(4):302-6.

Iwasaki J, Hata T, Hishikawa S, Fujimoto Y, Uemoto S, Murakami T, Kobayashi E.
Use of rat segmental intestine for fetal pancreatic transplantation.
Microsurgery. 2010 May;30(4):296-301.

Hakamata Y, Murakami T, Kobayashi E.
"Firefly rats" as an organ/cellular source for long-term in vivo bioluminescent imaging.
Transplantation. 2006 Apr 27;81(8):1179-84.