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Kawano, K., Hirashima, T., Mori, S., et al
Spontaneous long-term hyperglycemic rat with diabetic complications Otsuka Long-Evans Tokushima Fatty(OLETF) strain.
Diabetes 41:1422-1428, 1992.
Shima, K., Shi, K., Sano, T., et al
Is exercise training effective in preventing diabetes mellitus in the Otsuka-Long-Evans-Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus ?
Metabolism 42:971-977, 1993.
Sato, T., Asahi, Y., Toide, N., et al
Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a new model of NIDDM.
Diabetologia 38:1033-1041, 1995.
Hirashima, T., Kawano, K., Mori, S., et al
A diabetogenic gene(ODB-1) assigned to the X-chromosome in OLETF rats.
Diabetes Res. Clin. Pract. 27:91-96, 1995.
Unger, R.H.
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM, genetic and clinical implications.
Diabetes 44:863-870, 1995.
Hirashima, T., Kawano, K., Mori, S., et al
The influence of testosterone on the spontaneous hyperglycemic Otsuka Long-Evans Tokushima Fatty(OLETF) rat.
Int. J. Diabetes 4:85-92, 1996.
Mori, S., Kawano, K., Hirashima, T., et al
Relationships between diet control and the development of spontaneous typeⅡdiabetes and diabetic nephropathy in OLETF rats.
Diabetes Res. Clin. Pract. 33:145-152, 1996.
Hirashima, T., Kawano, K., Mori, S., et al
Assignment of the rat cholecystokinin A receptor gene to chromosome 14.
Rat Genome 2:136-139, 1996.
Hirashima, T., Kawano, K., Mori, S., et al
A diabetogenic gene, ODB2, identified on chromosome 14 of the OLETF rat and its synergistic action with ODB1.
Biochem. Biophys. Res. Commun. 224:420-425, 1996.
Takiguchi, S., Takata, Y., Funakoshi, A., et al
Disrupted cholecystokinin type-A receptor(CCKAR) gene in OLETF rats.
Gene 197:169-175, 1997.
Man, Z.-W., Zhu, M., Noma, Y., et al
Impairedβ-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM.
Diabetes 46:1718-1724, 1997.
Takiguchi, S., Takata, Y., Takahashi, N., Kataoka, K., Hirashima, T., Kawano, K., Miyasaka, K., Funakoshi, A., Kono, A.
A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene.
Am. J. Physiol. 274:E265-270, 1998.
Moralejo, D.H., Wei, S., Wei, K., Yamada, T., Matsumoto, K.
X-linked locus is responsible for non-insulin-dependent diabetes mellitus in the OLETF rat.
J. Vet. Med. Sci. 60:373-375, 1998.
Kanemoto, N., Hishigaki, H., Miyakita, A., Oga, K., Okuno, S., Tsuji, A., Takagi, T., Takahashi, E., Nakamura, Y., Watanabe, T. K.
Genetic dissection of “OLETF”, a rat model for non-insulin-dependent diabetes mellitus.
Mammalian Genome 9:419-425, 1998.
Moralejo, D.H., Ogino, T., Zhu, M., Toide, K., Wei, S., Wei, K., Yamada, T., Mizuno, A., Matsumoto, K., Shima, K.
A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat.
Mammalian Genome 9:794-798, 1998.
Wei, S., Wei, K., Moralejo, D.H., Ogino, T., Koike, G., Jacob, H.J., Sugiura, K., Sasaki, Y., Yamada, T., Matsumoto, K.
Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the otsuka long-evans tokushima fatty rat.
Mammalian Genome 10:249-258, 1999.
Ogino T, Moralejo DH, Zhu M, Toide K, Wei S, Wei K, Yamada T, Mizuno A, Matsumoto K, Shima K.
Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat.
Genet Res. 1999 Feb;73(1):29-36.
Watanabe TK, Okuno S, Oga K, Mizoguchi-Miyakita A, Tsuji A, Yamasaki Y, Hishigaki H, Kanemoto N, Takagi T, Takahashi E, Irie Y, Nakamura Y, Tanigami A.
Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.
Genomics. 1999 Jun 15;58(3):233-9.
Sugiura K, Miyake T, Taniguchi Y, Yamada T, Moralejo DH, Wei S, Wei K, Sasaki Y, Matsumoto K.
Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method.
Mamm Genome. 1999 Dec;10(12):1126-31.
Okuno S, Watanabe TK, Ono T, Yamasaki Y, Goto Y, Miyao H, Asai T, Kanemoto N, Oga K, Mizoguchi-Miyakita A, Takagi T, Takahashi E, Nakamura Y, Tanigami A.
Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.
Genomics. 1999 Dec 15;62(3):350-5.
Yamasaki Y, Watanabe TK, Okuno S, Ono T, Oga K, Mizoguchi-Miyakita A, Goto Y, Shinomiya H, Momota H, Miyao H, Hayashi I, Asai T, Suzuki M, Harada Y, Hishigaki H, Wakitani S, Takagi T, Nakamura Y, Tanigami A.
Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.
Clin Exp Pharmacol Physiol. 2000 Nov;27(11):881-6.
Ogino T, Wei S, Wei K, Moralejo DH, Kose H, Mizuno A, Shima K, Sasaki Y, Yamada T, Matsumoto K.
Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.
Genomics. 2000 Nov 15;70(1):19-25.
Watanabe TK, Okuno S, Ono T, Yamasaki Y, Oga K, Mizoguchi-Miyakita A, Miyao H, Suzuki M, Momota H, Goto Y, Shinomiya H, Hishigaki H, Hayashi I, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A.
Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat.
Clin Exp Pharmacol Physiol. 2001 Jan-Feb;28(1-2):28-42.
Okuno S, Watanabe TK, Ono T, Oga K, Mizoguchi-Miyakita A, Yamasaki Y, Goto Y, Shinomiya H, Momota H, Miyao H, Hayashi I, Asai T, Suzuki M, Harada Y, Hishigaki H, Wakitani S, Takagi T, Nakamura Y, Tanigami A.
Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.
Genet Res. 2001 Apr;77(2):183-90.
Yamada T, Miyake T, Sugiura K, Narita A, Wei K, Wei S, Moralejo DH, Ogino T, Gaillard C, Sasaki Y, Matsumoto K.
Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.
Exp Anim. 2001 Apr;50(2):115-23.
Kanemoto N, Kondo M, Iwanaga T, Hishigaki H, Ono T, Mizoguchi-Miyakita A, Oga K, Tsuji A, Okuno S, Watanabe TK, Nose M, Tanigami A.
Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene.
Pathol Int. 2001 Mar;51(3):133-9.
Okuno S, Kondo M, Yamasaki Y, Miyao H, Ono T, Iwanaga T, Omori K, Okano M, Suzuki M, Momota H, Hishigaki H, Hayashi I, Goto Y, Shinomiya H, Harada Y, Hirashima T, Kanemoto N, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A, Watanabe TK.
Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.
Diabetes Obes Metab. 2002 Sep;4(5):309-18.
Kose H, Moralejo DH, Ogino T, Mizuno A, Yamada T, Matsumoto K.
Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats.
Mamm Genome. 2002 Oct;13(10):558-62.
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