系統
系統:  BN/fMaiKa 
キーワード:  kininogen欠損、カリクレインーキニン系 (kallikrein-kinin system) 
由来:  BN (Brown Norway)は1958年にBillingham and Silversによって発見された。BN/KaはKatholiek University (Belgium)より1982年に北里大学へ供与された。 
表現型・病態:  毛色:チョコレート。 血漿kininogen欠損。heat-induced substance Pの欠損。BNラットに比べてdeoxycorticosterone acetate saltの高血圧誘導に過敏。 
病因(原因遺伝子):  肝臓における高分子量kininogen分泌の欠損はアラニン163のpoint mutationによる。 
臨床への応用、有用性:  薬理学、血液・リンパ系、アレルギー疾患、高血圧症、炎症 
維持機関:  北里大学薬学部薬理学教室 
文献:  Majima M, Adachi K, Kuribayashi Y, Mizogami S and Katori M Increase in vascular sensitivity to angiotensin-II and norepinephrine after 4-day infusion of 0.3 m sodium-chloride in conscious kininogen- deficient Brown-Norway Katholiek rats. Jpn. J. Pharmacol. 69, 149-158, 1995 Tang FD, Yonehara N, Imai Y, Takiuchi S, Inoki R, and Bian RL Releases of bradykinin and substance-P by heating hind paw of rat. Acta Pharmacologica Sinica 15, 232-234, 1994 Hayashi I, Hoshiko S, Makabe O and Oh-ishi S A point mutation of alanine 163 to threonine is responsible for the defective secretion of high molecular weight kininogen by the liver of Brown Norway Katholiek rats The Journal of Biological Chemistry, 268: 17219-17224. 1993 Oh-ishi S et al. Evidence for a role of the plasma kallikrein-kinin system in acute inflammation : reduced exudation during carrageenin- and kaolin-pleurisies in kininogen-deficient rats Agents and Actions, 18: 450-454. 1986 Oh-ishi S, Satoh K, Hayashi I, Yamazaki K, and Nakano T Differences in prekallikrein and high molecular weight kininogen levels in two strains of Brown Norway rat ( Kitasato strain and Katholiek strain) Thrombosis Research, 28: 143-147. 1982  
執筆者記録:  森田眞紀(京都大学)2003年3月, TS:4/21/03 
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