京都大学医学部附属動物実験施設報　第３号

動物実験施設利用者研究業績

（1996年〜1997年）

1）生理系専攻 (Physiology)

生体情報科学講座 (Biological Sciences)

　 生体情報科学分野 (Biological Sciences)

生体制御医学講座 (Bioregulation)

　 循環生理学分野 (Pharmacology)

2）病理系専攻 (Pathology)

基礎病態学講座 (Basic Pathology)

　 病態生物医学分野 (Pathology and Biology of Diseases)

感染・免疫学講座 (Infectious Diseases and Immunology)

　 免疫細胞生物学分野 (Immunology and Cell Biology)

3) 社会医学系専攻 (Social Medicine)

社会予防医学講座 (Social and Preventive Medicine)

　 法医学分野 (Legal Medicine)

4）分子医学系専攻 (Molecular Medicine)

分子生体統御学講座 (Moleculer Biology)

　 分子生物学分野 (Medical Chemistry)

分子細胞情報学分野 (Cell Biology)

　 分子腫瘍学分野 (Molecular Oncology)

遺伝医学講座 (Molecular Genetics）

　 分子遺伝学分野 (Molecular Genetics）

5）脳統御医科学系専攻 (Neuroscience)

高次脳科学講座 (Basic Neuroscience)

　 神経・細胞薬理学分野 (Cell Pharmacology)

6）内科系専攻 (Internal Medicine)

臨床病態医科学講座 (Medicine and Clinical Science)

　 臨床病態医科学分野 (Medicine and Clinical Science)

臨床器官病態学講座 (Clinical Sciences for Pathological Organs)

　 循環病態学（Cardiovascular Medicine)

　 消化器病態学分野 (Gastroenterology and Hepatology)

臨床生体統御医学講座 (Clinical Bioregulation)

　 成人・老年病病態学分野 (Geriatric Medicine)

　 臨床病態検査学分野 (Laboratory Medicine)

発生発達医学講座 (Developmental Medicine)

　 発達小児科学分野 (Pediatrics)

放射線医学講座 (Radiology and Nuclear Medicine)

　 核医学・画像診断学分野 (Nuclear Medicine and Diagnostic Imaging)

7）外科系専攻 (Surgery)

器官外科学講座 (Surgery for Visceral Organs)

　 消化器外科学分野 (Gastroenterological Surgery)

　 婦人科学産科学分野 (Gynecology and Obstetrics)

　 心臓血管外科学分野 (Cardiovascular Surgery)

感覚運動系病態学講座 (Surgery for Sensory and Motor Systems)

　 筋・骨格系病態学分野 (Orthopaedic and Musculoskeletal Surgery)

　 視覚病態学分野 (Ophthalmology and Visual Science)

8）分子医学系専攻 (Molecular Medicine)

遺伝医学講座 (Medical Genetics)

　 腫瘍外科学分野 (Surgery and Surgical Basic Science)

9) 附属動物実験施設 (Institute of Laboratory Animals)

10) 附属先天異常標本解析センター (Congenitary Anomaly Research Ceneter)

生体情報科学分野 (Biological Sciences)

Tomita, K., Ishibashi, M., Nakahara, K., Ang, S-L., Nakanishi, S., Guillemot, F. & Kageyama, R. (1996). Mammalian hairy and enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis. Neuron 16,723-734.

Yokoi, M., Kobayashi, K., Manabe, T., Takahashi, T., Sakaguchi, I., Katsuura, G., Shigemoto, R., Ohishi, H., Nomura, S., Nakamura, K., Nakao, K., Katsuki, M. & Nakanishi, S. (1996). Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science 273,645-647.

Isaka, F., Shimizu, C., Nakanishi, S. & Kageyama, R. (1996). Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. Genomics 37,400-402.

Kadotani, H., Hirano, T., Masugi, M., Nakamura, K., Nakao, K., Katsuki, M. & Nakanishi, S. (1996). Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J. Neurosci. 16,7859-7867.

Nakanishi, S., Nakajima, Y., Nomura, A., Masu, M., Iwakabe, H., Hayashi, Y. & Yokoi, M. (1997). Functions and roles of glutamate receptors in synaptic transmission and plasticity. Cold Spring Harbor Symposia on Quantitative Biology 61,67-75.

Iwakabe, H., Katsuura, G., Ishibashi, C. & Nakanishi, S. (1997). Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse. Neurophrmacology 36,135-143.

Ueda, Y., Iwakabe, H., Masu, M., Suzuki, M. & Nakanishi, S. (1997). The mGluR6 5' upstream transgene sequence directs a cell-specific and developmentally regulated expression in retinal rod and ON-type cone bipolar cells. J. Neurosci. 17,3014-3023.

Hashimoto, T., Inazawa, J., Okamoto, N., Tagawa, Y., Bessho, Y., Honda, Y. & Nakanishi, S. (1997). The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. Eur. J. Neurosci. 9,1226-1235.

循環生理学分野 (Pharmacology)

Shiraki, T., Koshimura, K., Kobayashi, S., Miwa, S., Masaki, T., Watanabe, Y., Murakami, Y., & Kato, Y. (1996). Stimulating effect of 6R-tetrahydrobiopterin on Ca2+ channels in neurons of rat dorsal motor nucleus of the vagus. Biochem Biophys Res Commun, 221: 181-185.

Sugawara, F., Ninomiya, H., Okamoto, Y., Miwa, S., Mazda, O., Katsura, Y., & Masaki, T. (1996). Endothelin-1-induced mitogenic responses of chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway. Mol Pharmacol, 49: 447-457.

Komuro, T., Miwa, S., Minowa, T., Okamoto, Y., Enoki, T., Ninomiya, H., Zhang, X.-F., Uemura, Y., Kikuchi, H., and Masaki, T. (1997) The involvement of a novel mechanism distinct from the thrombin receptor in the vasocontraction induced by trypsin. Br. J. Pharmacol., 120, 851-856.

Komuro, T., Miwa, S., Zhang, X.-F., Minowa, T., Enoki, T., Okamoto, Y., Ninomiya, H., Sawamura, T., Kikuta, K., Iwamuro, Y., Furutani, H., Hasegawa, H., Uemura, Y., Kikuchi, H., and Masaki, T. (1997) Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta. J. Cardiovasc. Pharmacol., 30, 504-509.

Minowa, T., Miwa, S., Kobayashi, S., Enoki, T., Zhang, X.-F., Komuro, T., Iwamuro, Y., and Masaki, T. (1997) Inhibitory effect of nitrovasodilators and cyclic GMP on ET-1-activated Ca2+-permeable nonselective cation channel in rat aortic smooth muscle cells. Br. J. Pharmacol., 120, 1536-1544.

Okamoto, Y., Ninomiya, H., Tanioka, M., Sakamoto, A., Miwa, S., & Masaki, T. (1997). Palmitoylation of human EndothelinB. J Biol Chem, 272: 21589-21596.

Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S., & Masaki, T. (1997). Cloning and characterization of a brain-specific cationic amino acid transporter. J Biol Chem, 272: 8717-8722.

Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T., & Masaki, T. (1997). An endothelial receptor for oxidized low density lipoprotein. Nature, 386: 73-77.

病態生物医学分野 (Pathology and Biology of Diseases)

Okamoto, K., Toyokuni, S., Kim, W-J., Ogawa, O., Kakehi, Y., Arao, S., Hiai, H., Yoshida, O. Overexpression of human mutT homologue gene MTH1 messenger RNA in renal cell carcinoma: evidence for persistent oxidative stress in cancer. Int. J. Cancer 65:437-441, 1996.

Shisa, H., Yamada, Y., Kawarai, A., Terada, N., Kawai, M., Matsushiro, H., Hiai, H. Genetic and epigenetic resistance of SL/Ni mice to lymphomas. Jpn. J. Cancer Res. 87: 258-262, 1996.

Kamoto, T., Shisa, H., Abujiang, P., Lu, L-M., Yoshida, O., Yamada, Y., Hiai, H. A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas. Jpn. J. Cancer Res. 87: 401-404, 1996.

Hiai, H. Genetic predisposition to lymphomas in mice. Pathol. Intern. 46: 707-718, 1996. Abujiang, P., Yamada, Y., Haller, O., Kobayashi, K.,Kamoto, T., Lu, L.M., Ogawa, M., Ishimoto, A., Katoh, H., Kanehira, K., Ikegami, S., Fukumoto, M., Hiai, H.. The origin of the SL family mice. Lab. Anim. Sci. 46: 410-417, 1996.

Tsubata, R. , Tsubata, T., Hiai, H., Shinkura, R., Matsumura, R., Sumida, T., Miyawaki, S., Kumagai, S., Nakao, K., Honjo, T. Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: A single gene model for Sjogren syndrome. Eur. J. Immunol. 26: 2742-2748, 1996.

Shinkura, R., Matsuda, F., Sakiyama, T., Tsubata, T., Hiai, H., Paumen, M., Miyawaki, S., Honjo, T. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. Intern. Immunol. 8: 1067-1075, 1996.

Matsushima, Y., Kamoto, T., Iida, F., Abujiang, P., Honda, Y, Hiai, H. Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics 36: 553-554, 1996.

Abujiang, P., Kamoto, T., Lu, L.M., Yamada, Y., Hiai, H. Two dominant resistance genes to pre-B lymphoma in a wild-derived inbred mouse strain MSM/Ms. Cancer Res. 56: 3716-3720, 1996.

Toyokuni, S., Tanaka, T., Nishiyama, Y., Okamoto, K., Nakashima, Y., Hamazaki, S., Okada, S., Hiai,.H. Induction of renal cell carcinoma in male Wistar rats treated with cupric nitriloacaqtate. Lab. Invest. 75: 239-248, 1996.

Kubo, Y., Kakimi, K., Higo, K., Kobayashi, H., Ono, T., Iwama, Y., Kuribayashi, K., Hiai, H., Adachi, A., Ishimoto, A. Possible origin of murine AIDS (MAIDS) virus: conversion of an endogenous retroviral p12gag sequence to a MAIDS-inducing sequence by frameshift mutations. J. Virol. 70: 6405-6409, 1996.

Iida, F., Matsushima, Y., Hiai, H., Uga, S., Honda, K. Rupture of lens cataract: A novel hereditary recessive cataract model in the mouse. Exp. Eye Res. 64: 107-113, 1997.

Hattori, Y., Nishigori, C., Tanaka, T., Uchida, K., Nikaido, O., Osawa, T., Hiai, H., Imamura, S., Toyokuni, S. 8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. Invest. Dermatol. 107: 733-737, 1997.

Higo, K., Kubo, Y., Iwatani, Y., Ono, T., Maeda, M., Hiai, H., Masuda, T., Kuribayashi, K., Zhang, F., Lamin, TR.Y., Adachi, A., Ishimoto, A. Susceptibility of nude mice carrying the Fv-4 gene to Friend murine leukemia virus infection. J. Virol. 71: 750-754, 1997.

Lu, L-M., Ogawa, M., Kamoto, T., Yamada , Y., Abujiang, P., Hiai, H Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/Kh mice. Leuk Res. 21: 337-342, 1997.

Toyokuni, S., Luo, X-P., Tanaka, T., Uchida, K., Hiai, H., Lehotay, D.C. Induction of a wide range of C2-12 aldehydes and C7-12 acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate. Free Rad. Biol. Med. 22: 1019-1027, 1997.

Nishiyama, Y., Tanaka, T., Naitoh, H., Mori, C., Fukumoto, M., Hiai, H., Toyokuni, S. Overexpression of integrin-associated protein (CD47) in rat kidney treated with a renal carcinogen, ferric nitrilotriacetate. Jpn. J. Cancer Res. 88:120-128. 1997.

Shisa, H., Lu, L, Kamoto, T., Kawarai, A., Tanuma, J., Matsushima, Y., Hiai, H. LEXF: A new set of rat recombinant inbred strains between LE/Stm and F344. Mammal. Genome 8: 324-327, 1997.

Toyokuni, S., Tanaka, T., Hattori, Y., Nishiyama, Y., Yoshida, A., Uchida, K., Hiai, H., Ochi, H., Osawa, T. Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitriloacetate-induced renal carcinogenesis model. Lab. Invest. 76: 365-374, 1997.

Kamoto T., Mori S., Murai, T., Yamada, Y., Makino, S., Yoshida, O., Hiai H. Quantitative trait loci associated with promoting effects of sodium L-ascorbate on two stage bladder carcinogenesis in rats. Jpn. J. Cancer Res. 88: 633-638, 1997.

Abujiang, P., Nishimura, M., Kamoto, T., Ichioka, K., Sato, M., Hiai, H. Genetic resistance to urethane induced pulmonary adenomas in SMXA RI strains. Cancer Res. 57:2904-2908, 1997

Wang, Y., Nose, M., Kamoto, T., Nishimura, M., Hiai, H. Host modifier genes affecting mouse auto-immunity induced by Lpr gene. Amer. J. Pathol. 151: 1791-1798, 1997.

Tanaka, T., Nishiyama, Y., Okada, K., Hirota, K., Matsui, M., Yodoi, J., Hiai. H., Toyokuni, S. Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab. Invest. 77: 145-55, 1997.

Hiai, H., Yamada, Y., Shisa, H., Kamoto, T., Abujiang, P., Lu, LM. To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models. Leukemia. Suppl 3: 193-194, 1997.

日合　弘、阿不江パタール、賀本敏行、西村正彦 肺癌の感受性遺伝子 Molecular Medicine 32: 676-681, 1997

免疫細胞生物学分野 ( Immunology and Cell Biology )

Sugie, T., Kubota, H., Sato, M., Nakamura, E., Imamura, M., and Minato, N. 1996. NK1+CD4-CD8- ab T cells in the peritoneal cavity: Specific T cell receptor-mediated cytotoxicity and selective interferon g production against B-cell leukemia and myeloma cells. J. Immunol.157:3925-3935

Kurachi, H., Wada, Y., Tsukamoto, N, Maeda, M., Kubota, H., Hattori, M, Iwai, K., and Minato, N. 1997. Human SPA-1 Gene Product Selectively Expressed in Lymphoid Tissues is a Specific GTPase-activating Protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. J. Biol. Chem. 272:28081-28088.

Nakamura, E., Kubota, H., Sato, M., Sugie, T., Yoshida, O., and Minato, N. 1997. Involvement of NK1+CD4-CD8- abT cells and endogenous interleukin 4 in non-MHC restricted rejection of embryonal carcinoma in genetically resistant mice. J. Immunol.158: 5338-5348.

Wada, Y., Kubota, H., Maeda, M., Taniwaki, M., Hattori, M., Imamura, S., Iwai, K., and Minato, N. 1997. Mitogen-inducible SPA-1 is mapped at the conserved syntenic groups of the chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human. Genomics 39:66-73.

法医学分野 (Legal Medicine)

Ojima, K., Abiru, H., Matsumoto, H., and Fukui, Y. (1996). Effects of postnatal exposure to cocaine on the development of the rat corpus callosum. Reprod. Toxicol., 10, 221-225.

Ojima, K., Abiru, H., Matsumoto, H., Hayase, T., Matsubayashi, K., Nakamura, C., and Fukui, Y. (1996). Effects of postnatal cocaine on differentiation of the rat corpus callosum. Jpn. J. Legal. Med., 50, 156-162.

Ojima, K., Abiru, H., and Fukui, Y. (1996). Effects of cocaine on the rat cerebral commissure. Int. J. Dev. Neurosci., 14, 649-654.

分子生物学分野 (Medical Chemistry)

Nishimura, H., Agata, Y., Kawasaki, A., Sato, M., Imamura, S.,Minato, N., Yagita, H., Nakano, T. and Honjo, T.Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. I. Immunol. 8 773-780 (1996)

Shinohara, T. and Honjo, T.Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro. Eur.J. Immunol. 26 747-752 (1996)

Nomura, T., Han, H., Howard, M.C., Yagita, H., Yakura, H., Honjo, T. and Tsubata, TAntigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. . I. Immunol. 8 867-875 (1996)

Kurooka, H., Segre, JA., Hirano, Y., Nemhauser, JL., Nishimura, H., Yoneda, K., Lander, ES. and Honjo, T. Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus. I. Immunol. 8 961-966 (1996)

Shinkura, R., Matsuda, F., Sakiyama, T., Tsubata, T., Hiai, H., Paumen, M., Miyawaki, S. and Honjo, T. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. I. Immunol. 8 1067-1075 (1996)

Tsubata, R., Tsubata, T., Hiai, H., Shinkura, R., Matsumura, R., Sumida, T., Miyawaki, S., Kumagai, S., Nakao, K, and Honjo,TAutoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjoegren's syndrome. . Eur. J.Immunol. 26 2742-2748 (1996)

Han, H., Nomura, T., Honjo, T. and Tsubata, T. Differential modulation of cyclin-dependent kinase inhibitor p27kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40. Eur. J. Immunol. 26 2425-2432 (1996)

Maki, K., Sunaga, S., Komagata, Y., Kodaira, Y., Mabuchi, A., Karasuyama, H., Yokomuro, K., Miyazaki, J., and Ikuta, K. (1996) Interleukin 7 receptor-deficient mice lack gd T cells. Proc. Natl. Acad. Sci. USA., 93:7172-7177.

Yoshida, T., Ikuta, K., Sugaya, H., Maki, K., Takagi, M., Kanazawa, H., Sunaga, S., Kinashi, T., Yoshimura, K., Miyazaki, J., Takaki, S., and Takatsu, K. (1996) Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5Ra-deficient mice. Immunity, 4:483-494.

Kanamori, Y., Ishimaru, K., Nanno, M., Maki, K., Ikuta, K., Nariuchi, H., and Ishikawa, H. (1996). Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c- kit+ IL-7R+ Thy1 + lympho-hemopoietic progenitors develop. J. Exp. Med., 184:1449-1459.

Maki, K., Sunaga, S., and Ikuta, K. (1996). The V-J recombination of T cell receptor g genes is blocked in interleukin-7 receptor-deficient mice. J. Exp. Med., 184:2423-2427.

Shinohara, T. and Honjo, T.Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus. Eur. J. Immunol. 27 522-529 (1997)

Murakami, M., Nakajima, K., Yamazaki, K., Muraguchi,T.,Serikawa,T.and Honjo, T.Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti- red blood cell autoantibody transgenic mice. J. Exp. Med. 185 791-794 (1997)

Nisitani, S., Murakami, M. and Honjo, T.Anti-red blood cell immunoglobulin transgenic mice: An experimental model of autoimmune hemolytic anemia. Annals New York Academy of Sciences 815 246-252 (1997)

Murakami, M. and Honjo, T. Transgenic mouse models for B-cell dominant autoimmune diseases Curr. Opin. in Immunol. 9 846-850 (1997)

Sunaga, S., Maki, K., Komagata, Y., Ikuta, K., and Miyazaki, J. (1997). Efficient removal of loxP-flanked sequences in a gene-targeted locus by transient expression of Cre recombinase in ertilized eggs. Mol. Reprod. Dev., 46: 109-113.

Sunaga, S., Maki, K., Lagasse, E., Blanco, J. C. G., Ozato, K., Miyazaki, J., and Ikuta, K. (1997). Myeloid differentiation is impaired in transgenic mice with targeted expression of a dominant negative form of retinoid X receptor b. Brit. J. Haematol., 96:19-30.

Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga, I., Kume, K., Miyazaki, J., and Shimizu, T. (1997). Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J., 16:133-142.

Sunaga, S., Maki, K., Komagata, Y., Miyazaki, J., and Ikuta, K. (1997). Developmentally ordered V-J recombination in mouse T cell receptor g locus is not perturbed by targeted deletion of the V g 4 gene. J. Immunol., 158:4223-4228.

Takeuchi, T., Ueki, T., Sunaga, S., Ikuta, K., Sasaki, Y., Li, B., Moriyama, N., Miyazaki, J., and Kawabe, K. (1997). Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the Th1 cytokine mRNA in grafts. Transplantation., 64:152-157.

Miyaura C., Onoe, Y., Inada, M., Maki, K., Ikuta, K., Ito, M., and Suda, T. (1997). Increased B-lymphopoiesis by Interleukin 7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency. Proc. Natl. Acad. Sci. USA., 94:9360-9365.

Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J., and Shimizu, T. (1997). Role of cytosolic phospholipase A2 in allergic response and parturition. Nature, 390:618-622.

分子細胞情報学分野 (Cell Biology)

Furuse,M., Fujimoto,K., Sato,N., Hirase,T., Tsukita,Sa., and Tsukita,Sh. (1996). Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J.Cell Sci., 109, 429-435.

Tokai,N., Fujimoto-Nishiyama,A., Toyoshima,Y., Yonemura,S., Tsukita,Sh., Inoue,J., and Yamamoto,T. (1996). Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. EMBO J. , 15, 457-467.

Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A., Itoh,M., Yonemura,S., Furuse,M., and Tsukita,Sh. (1996). Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog and rat-kangaroo homologues. J.Cell Biol., 133, 43-47.

Hirao,M., Sato,N., Kondo,T., Yonemura,S., Monden,M., Sasaki, T., Takai,Y., Tsukita,Sh. and Tsukita,Sa (1996). Regulation mecanism of ERM(Ezrin/Radixin/Moesin) protein/plasma membrane association: Possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J.Cell Biol., 135, 37-51.

McCarthy, K.M., Skare,I.B., Stankewich,M.C., Furuse,M., Tsukita,Sh., Rogers,R.A., Lynch,R.D., and Schneeberger,E.E. (1996). Occludin is a functional component of the tight juncton. J.Cell Sci., 109, 2287-2298.

Tsukita,Sh., Furuse,M., and Itoh,M. (1996). Molecular dissection of tight junctions. Cell Struct. Funct., 21, 381-385.

月田承一郎（1996）.　細胞間と細胞の相互作用。中山書店、最新内科学大系2（別冊）181-187.

Hirase, T., Furuse, M., and Tsukita, Sh. (1997). A 155 kDa undercoat-constitutive protein of cell-to-cell adherens junctions. Eur. J. Cell Biol. 72, 174-181.

Saitou, M., Akatsuka-Ando Y., Ito, M., Furuse, M., Inazawa, J., Fujimoto, K., and Tsukita, Sh. (1997). Mammalian occludin in epithelial cells: Its expression and subcellular distributution. Eur. J. Cell Biol., 73, 222-231.

Tsukita, Sa., Yonemura, S., and Ysukita, Sh. (1997). ERM proteins; Head-to-tail regulation of actin/plasma membrane interaction. TIBS, 22, 53-58.

Sakakibara, A., Furuse, M., Saitou, M., Anodo-Akatusuka, Y., and Tsukita, Sh. (1997). Possible involvement of phosphorylation of occludin in tight junction formation. J. Cell Biol., 137, 1393-1401.

Fujimoto, K., Nagafuchi, A., Tsukita, Sh., Kuraoka, A., Ohokuma, A., and Shibata, Y. (1997). Dynamics of connexins, E-cadherin and alpha catenin on cell membranes during gap junction formation. J. Cell. Sci., 110, 311-322.

Hirase, T., Staddon, J.M., Saitou, M., Akatsuka-Ando, Y., Itoh, M., Furuse, M., Fujimoto, K., Tsukita, Sh., and Rubin, L. (1997). Occludin as a possible determinant of tight junction permiability in endothelial cells. J. Cell Sci., 110, 1603-1613.

Itoh, M., Nagafuchi, A., Moroi, S., and Tsukita, Sh. (1997). Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to a catenin and actin filaments. J. Cell Biol., 138, 181-192.

Kimura, Y., Shiozaki, H., Hirao, M., Maeno, Y., Doki, Y., Inoue, M., Monden, T., Ando-Akatsuka, Y., Furuse, M., Tsukita, Sh., and Monden, M. (1997). Expression of occludin, tight junction-associated protein, in human digestive tract. Am. J. Pathol., 151, 45-54.

Tsukita, Sh., Furuse, M., and Itoh, M. (1997). Molecular architecture of tight junctions: Occuludin and ZO-1 Cytoskeletal Regulation of Membrane Functions., 69-76.

Mandai, K., Nakanishi, H., Satoh, A., Obaishi, H., Wada, M., Nishioka, H., Itoh, M., Aoki, T., Fujimoto, T., Matsuda, Y., Mizoguchi, A., Tsukita, Sh., and Takai, Y. (1997). Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol., 139, 517-528.

Kondo, T., Takeuchi, K., Doi, Y., Yonemura, S., Nagata, S., Tsukita, Sh., Tsukita, Sa. (1997). ERM (Ezrin/Radixin/Moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis. J. Cell Biol., 139, 749-758.

Takahashi, K., Sasaki, T., Mammoto, A., Takahashi, K., Kaneyama, T., Tsukita, Sa., Tsukita, Sa., and Takai, Y. (1997). Direct interaction of the rho GDP dissociation inhibition with Ezrin/Radixin/Moesin initiates the activation of the rho small G protein. J. Biol. Chem., 272, 23371-23375.

Sagara, J., Tochikura, T. S., Yamamoto, Y., Tsukita, Sh., Tsukita, Sa., and Kawai, A. (1997). Immunological studies of a 21 kDa cellular component efficiently incorporated into Rabies virion grown in a BHK-21 cell culture. Microbiol. Immunol., 41, 947-955.

Tsukita, Sh., Furuse, M., and Itoh, M. (1990). Molecular dissection of tight junctions: occludin and ZO-1. An Introduction to the Blood-Brain Barrier., 322-329, Pardridge, W.M., (eds.), Cambridge University Press.

月田承一郎（1997）、細胞間をシールする新しい接着分子オクルディン、Bio Clinica、12、52-55.

月田承一郎（1997）、タイトジャンクションの分子構築と機能、蛋白質核酸酵素、42、220-224.

月田承一郎（1997）、細胞間の漏れを防ぐ膜内蛋白質オクルディン、カレントレビュー、15、116-121.

分子腫瘍学分野 (Molecular Oncology)

Kinoshita, M., Kumar, S., Mizoguchi, A., Ide, C., Kinoshita, A., Haraguchi, T., Hiraoka, Y. and Noda M. (1997). Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes & Development 11, 1535 -1547.

Kinoshita, M., Tomimoto, H., Kinoshita, A., Kumar, S. and Noda, M. (1997). Up-regulation of the Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient global ischemia. Journal of Cerebral Blood Flow and Metabolism 17, 507-514.

Kumar, S., Kinoshita, M., Dorstyn, L. and Noda, M. (1997). Origin, expression and possible functions of the two alternatively spliced forms of the mouse Nedd2 mRNA. Cell Death and Differentiation.4: 378-387.

Kumar, S., Harvey, K.F., Kinoshita, M., Copeland, N.G., Noda, M., and Jenkins, N.A. (1997). cDNA cloning, expression analysis and mapping of the mouse Nedd4 gene. Genomics 40, 435-443.

分子遺伝学分野 (Molecular Genetics）

Yasunaga M, Yagi T, Hanzawa N, Yasuda M, Yamanashi Y, Yamamoto T, Aizawa S, Miyauchi Y, Nishikawa SI: Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor. J. Cell Biol. 132, 19-26, 1996

Kunisada T, Yoshida H, Ogawa M, Shulz LD, and Nishikawa SI: Characterization and isolation of melanocyte progenitors from mouse embryos Dev. Growth. Diff. 38, 87-98, 1996

Kanatsu M and Nishikawa SI. In vitro analysis of epiblast tissue potency for hematopoietic cell differentiation. Development 122, 831-838, 1996

Yoshida H, Kunisada T, Kusakabe M, Nishikawa S, and Nishikawa SI: Distinct stages of melanocyte differntiation revealed by analysis of nonuniform pigmentation patterns. Development 122, 1207-1214, 1996

Itoh N, Masahiro Yasunaga M, Hirashima M, Yoshida O, Nishikawa SI: Role of IL-7 and KL in activating molecules controlling the G1/S transition of B precursor cells. Int. Immunol. 8: 317-324, 1996

Fujihashi K, Kawabata S., Hiroi T, Yamamoto M, McGhee JR, Nishikawa SI, Kiyono H.: Proc. Natl.Acad Sci. USA. 93:3613-3618, 1996.

Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa SI, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T: Defects of B lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382, 635-638, 1996

Tsuchida K, Sawchenko PE, Nishikawa SI, and Vale WW: Molecular cloning of a novel typeI receptor serine/threonine kinase for the TGFb superfamily from rat brain. Mol. Cell. Neurosci. 7, 467-478, 1996

Takakura N, Yoshida H, Kunisada T, and Nishikawa SI: Involvement of platelet derived growth factor receptora in hair canal formation. J.Inv. Dermatol. 107, 770-777, 1996

Fruttiger, M., Calver, A., Kruger, W.H., Mudhar, H.S., Michalovich, D.,Takakura, N., Nishikawa, S.-i and Richardson, W.D. (1996). PDGF mediates a neuron-astrocyte interaction in the developing retina. Neuron, 17, 1117-1131, 1996

Takakura N, Kodama H, Ogawa M, Nishikawa S, and Nishikawa SI: Preferential proliferation of murine colony forming units in culture in a chemically defined condition with a macrophage colony stimulating factor negative stromal cell clone.　J. Exp. Med. 184, 2301-2311, 1996

Yoshida H, Hayashi SI, Schulz LD, Yamamura K, Nishikawa S, Nishikawa SI and Kunisada T: Neural and skin cell-specific expression pattern conferred by steel factor regulatory sequence in transgenic mice. Dev. Dynamics 207, 222-232, 1996

Torihashi S, Yoshida H, Nishikawa SI, and Sanders KM: Enteric neurons express steel factor-lacZ transgene in the murine gastrointestinal tract. Brain Res. 738, 323-328, 1996

Sato D, Lai ZF, Tokutomi N, Tokutomi Y; Maeda H; Nishikawa S; Nishikawa SI, Ogawa M, Nishi-K : Impairment of Kit-dependent development of interstitial cells alters contractile responses of murine intestinal tract. Am-J-Physiol. 271, G762-71, 1996

Takakura N, Yoshida H, Ogura Y, Kataoka H, Nishikawa S, and Nishikawa SI: PDGFRa expression during mouse embryogenesis: Immunolocalization analyzed by whole mount immunostaining using the monoclonal anti-mouse-PDGFRa antibody APA5.　J.Histchem. Cytochem. 45, 883-892, 1997

Hayashi SI, Miyamoto A, Yamane T, Kataoka H, Ogawa M, Sugawara S, Nishikawa S, Nishikawa SI, Sudo T, Yamazaki H, Kunisada T: Osteoclast precursors in bone marrow and peritoneal cavity. J. Cell. Physiol. 170, 241-247, 1997

Sakamaki K, Yoshida H, Nishimura Y, Nishikawa SI, Manabe N, and Yonehara: Involvement of Fas antigen in ovarian folliclular atresia and luteolysis. Mol. Reprod. Devel. 47, 11-18, 1997

Adachi S, Yoshida H, Kataoka H, and Nishikawa SI: Three distinctive steps in Peyerﾕs patch formation of murine embryo. Int.Immunol. 9, 507-514, 1997

Yoshida H, Takakura N, Kataoka H, Kunisada T, Okamura H, and Nishikawa SI: Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicle development. Dev. Biol. 184, 122-137, 1997

Itoh K, Friel J, Laker C, Zeller W, Just-U, Bittner S, Nibbs RJ, Harrison PR,Nishikawa SI, Mori KJ, Ostertag W: The role of soluble growth factors in inducing transient growth and clonal extinction of stroma cell dependent erythroblastic leukemia cells. Leukemia. 11,1753-61, 1997

Kamdar SJ, Fuller JA, Nishikawa SI, Evans R : Priming of mouse macrophages with the macrophage colony-stimulating factor (CSF-1) induces a variety of pathways that regulate expression of the interleukin 6 (Il6) and granulocyte-macrophage colony-stimulating factor (Csfgm) genes.Exp Cell Res. 235, 108-16, 1997

Kataoka H, Takakura N, Nishikawa S, Tsuchida K, Kodama H, Kunisada T, Risau W, Kita T and Nishikawa SI: Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells Dev. Growth. Diff. 39, 729-740, 1997

神経・細胞薬理学分野 (Cell Pharmacology)

Watanabe, G., Saito, Y., Madaule, P., Ishizaki, T., Fujisawa, K., Morii,N., Mukai, H., Ono, Y., Kakizuka, A. & Narumiya, S. (1996) Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science, 271, 645-648

Ishizaki, T., Maekawa, M., Fujisawa, K., Ohkawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Saito, Y., Kakizuka, A., Morii, N. & Narumiya, S. (1996) The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J., 15, 1885-1893

Hirata, T., Ushikubi, F., Kakizuka, A., Okuma, M. & Narumiya, S. (1996) Two thromboxane A2 receptor isoforms in human platelets: opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J. Clin. Invest., 97, 949-956

Momiyama, T., Todo, N., Sugimoto, Y., Ichikawa, A. & Narumiya., S. (1996) Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn-Schmiedeberg's Arch. Pharmacol., 353, 377-381

Ishikawa, T., Tamai, Y., Rochelle, J.M., Hirata, M., Namba, T., Sugimoto, Y., Ichikawa, A., Narumiya, S., Taketo, M. & Seldin, M.F. (1996) Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. Genomics, 32, 285-288

Reid, T., Furuyashiki, T., Ishizaki, T., Watanabe, G., Watanabe, N., Fujisawa, K., Morii, N., Madaule, P. & Narumiya, S. (1996) Rhotekin, a new Rho target protein bearing homology to a serine/threonine kinase, PKN, and rhophilin in the Rho-binding domain. J. Biol. Chem., 271, 13556-13560

Fujisawa, K., Fujita, A., Ishizaki, T., Saito, Y. & Narimiya, S. (1996) Identification of the Rho binding domain of p160 ROCK, a Rho-associated coiled-coil containing protein kinase. J. Biol. Chem., 271, 23022-23028

Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K. & Narumiya, S. (1996) ROCK-I and ROCK-II, two isoforms of Rho-associated coild-coil forming protein serine/threonine kinase in mice. FEBS Lett., 392, 189-193

Shibata, H., Mukai, H., Inagaki, Y., Homma, Y., Kimura, K., Kaibuchi, K., Narumiya, S. & Ono, Y. (1996) Characterization of the interaction between RhoA and the amino-terminal region of PKN. FEBS Lett., 385, 221-224

Yano, Y., Saito, Y., Narumiya, S. & Sumpio, B.E. (1996) Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochem. Biophys. Res. Commun., 224, 508-515

Narumiya, S. (1996) The small GTPase Rho: cellular functions and signal transduction. J. Biochem. (Tokyo), 120, 215-228

Ikeda, H., Yamaguchi, M., Sugai, S., Aze, Y., Narumiya, S. and Kakizuka, A. (1996) Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and n vivo. Nature Genetics, 13, 196-202

Tilly, B.C., Edixhoven, M.J., Tertoolen, L.G.J., Morii, N., Narumiya, S. and de Jong, H.R. (1996) Activation of the osmo-sensitive chloride conductance involves p21 rho and is accompanied by a transient reorganization of the F-actrin cytoskeleton. Mol. Biol. Cell, 7, 1419-1427

Todaka, M., Hayashi, H., Imanaka, T., Mitani, Y., Kamohara, S., Kishi, K., Tamaoka, K., Kanai, F., Shichiri, M., Morii, N., Narumiya, S. & Ebina, Y. (1996) Roles of insulin, guanosine 5'-[g-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation. Biochem. J., 315, 875-882

Suda, M., Tanaka, K., Natsui, K., Usui, T., Tanaka I., Fukushima, M., Shigeno, C., Konishi, J., Narumiya, S., Ichikawa, A. and Nakao, K. (1996) Prostaglandin E receptor subtypes in mouse osteoblastic cell line. Endocrinology, 137, 1698-1705

Morii, K., Tanaka, I., Kotani, M., Miyaoka, F., Sando, T., Muro, S., Sasaki, Y., Nakagawa, O., Ogawa, Y., Usui, T., Ozaki, S., Ichikawa, A., Narumiya, S. & Nakao, K. (1996) Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester. J. Mol. Med., 74, 333-336

Narumiya, S. (1996) Prostanoid receptors and signal transduction. Prog. Brain Res., 113 (The Polymodal Receptor- A Gateway to Pathological Pain), pp. 231-241, Elsevier, Amsterdam.

Kishi, K., Hayashi, H., Wang, L., Kamohara, S., Tamaoka, K., Shimizu, T., Ushikubi, F., Narumiya, S., and Ebina, Y. (1996) Gq-coupled receptors transmit the signal for GLUT4 translocation via an insulin-independent pathway. J. Biol. Chem., 271, 26561-26568

Takebayashi, H., Oida, H., Fujisawa, K., Yamaguchi, M., Hikida, T., Fukumoto, M., Narumiya, S. and Kakizuka, A. (1996) Hormone-induced apoptosis by Fas-nuclear receptor fusion proteins: novel biological tools for controling apoptosis in vitro. Cancer Res., 56, 4164-4170

Hirakata, H., Ushikubi, F., Toda, H., Nalamura, K., Sai, A., Urabe, N., Hatano, Y., Narumiya, S., and Mori, K. (1996) Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. Anesthesiol., 85, 1447-1453

Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao., K., Jockusch, B.M., and Narumiya, S. (1997) p140 mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J., 16, 3044-3056

Hirai, A., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Tatsuno, I., Oeda, T., Tahara, K., Terano, T., Narumiya, S., Kohn, L.D. and Saito, Y. (1997) Geranylgeranylated Rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J. Biol. Chem., 272, 13-16

Ishizaki, T., Naito, M., Fujisawa, K., Maekawa, M., Watanabe, N., Saito, Y. and Narumiya, S. (1997) p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett, 404, 118-124

Narumiya, S., Ishizaki, T. & Watanabe, N. (1997) Minireview: Rho effectors and reorganization of actin cytoskeleton. FEBS Lett., 410, 68.

Kobayashi, T., Kiriyama, M., Hirata, M., Ushikubi, F. & Narumiya, S.(1997) Identification of domains confering ligand binding specificity to the prostanoid receptor; studies on chimeric prostacyclin/prostaglandin D receptors. J. Biol. Chem., 272, 15154-15160

Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., Ueno, A., Oh-ishi, S. & Narumiya, S. (1997) Altered pain perception and inflammatory responses in mice lacking prostacyclin receptor. Nature, 388, 678-682

Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A. & Narumiya, S. (1997) Failure of parturition in mice lacking the prostaglandin F receptor. Science , 277, 681-683

Suzuki, F., Miyamoto, S., Takita, M., Oshita, M., Watanabe, Y., Kakizuka, A., Narumiya, S., Taniguchi, T., and Muramatsu, M. (1997) Cloning, functional expression and tissue distribution of rabbit a1d-adrenoreceptor. Biochim. Biophys. Acta 1323, 6-11

Kiriyama, M., Ushikubi, F., Kobayashi, T. & Narumiya, S. (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol., 122, 217-224

Morimoto, K., Sugimoto, Y., Katsuyama, M., Oida, H., Tsuboi, K., Kishi, K., Kinoshta, Y., Negishi, M., Chiba, T., Narumiya, S. and Ichikawa, A. (1997) Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract. Am. J. Physiol., 272, G681-687

Sasaki, Y., Takahashi, T., Tanaka, I., Nakamura, K., Okuno, Y., Nakagawa, O., Narumiya, S. and Nakao, K. (1997) Expression of prostacyclin receptor in human megakaryocytes. Blood, 90, 039-1046

Ushikubi, F., Hirata, M. and Narumiya, S. (1997) Platelet prostaglandin receptors. in Handbook of Experimental Pharmacology vol. 126 Platelets and their functions (Ed. von Bruchhausen, F. and Walter, U.), Springe Verlag, Berlin

Fujita, A., Saito, Y., Ishizaki, T., Maekawa, M., Fujisawa, K., Ushikubi, F., and Narumiya, S. (1997) Integrin-dependent translocation of p160ROCK,to a cytoskeletal complex in thrombin-stimulated human platelets. Biochem. J., 328, 769-775

Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., , Yamagami, K., Inui, J., Maekawa, M. and Narumiya, S. (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389, 990-994

Oida. H., Hirata, M., Sugimoto, Y., Ushikubi, F., Ohishi, H., Mizuno, N., Ichikawa, A. and Narumiya, S. (1997) Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain. FEBS Lett., 417, 53-56.

Kotani, M., Tanaka, I., Ogawa, Y., Usui, T., Tamura, N., Mori, K., Narumiya, S., Yoshimi, T., and Nakao, K. (1997) Structural Organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). Genomics, 40, 425-434

Tone, Y., Inoue, H., Hata, S., Yokoyama, C., Hatae, T., Oida, H., Narumiya, S., Shigemoto, R., Yukawa, S. and Tanabe, T. (1997) The regional distribution and cellular localization of mRNA encoding rat prostacyclin synthase. Eur. J. Cell Biol., 72, 268-277

Ding, M., Kinoshita, Y., Kishi, K., Nakata, H., Hassan, S., Kawanami, C., Sugimoto, Y., Katsuyama, M., Negishi, M., Narumiya, S., Ichikawa, A. and Chiba, T. (1997) Distribution of prostaglandin E receptors in the rat gastrointestinal tract. Prostaglandins, 53, 199-216

Nakamoto, M., Takebayashi, H., Kawaguchi, Y., Narumiya, S., Taniwaki, M., Nakamura, Y., Ishikawa, Y., Akiguchi, I., Kimura, J. and Kakizuka, A. (1997) A CAG/CTG expansion in the normal population. Nature Genetics. 17, 385-386.

臨床病態医科学分野 (Medicine and Clinical Science)

小川佳宏、田村尚久、中尾一和（1996）ナトリウム利尿ペプチドおよび受容体ノックアウトマウスの高血圧.　内分泌・糖尿病科、3、77-82.

田村尚久、小川佳宏、中尾一和（1996）ANP およびANP受容体のノックアウトマウスと電解質代謝. BIO Clinica、11(14)、37(1059)-40(1062).

Ebihara, K., Ogawa, Y., Isse, N., Mori, K., Tamura, N., Masuzaki, H., Kohno, K., Yura, S., Hosoda, K., Sagawa, N., and Nakao, K (1997). Identification of the human leptin 5'-flanking sequences involved in the trophoblast-specific transcription. Biochem. Biophys. Res. Commun., 241, 658-663.

小川佳宏、須田道雄、田村尚久、八十田明宏、田中　清、中尾一和（1997）　体液性因子における骨・血管相互作用　─ナトリウム利尿ペプチドファミリーの骨軟骨代謝調節作用─.　CLINICAL CALCIUM、7(9)、43-47.

田村尚久、伊藤　裕、小川佳宏（1997）　心房性ナトリウム利尿ペプチド遺伝子と高血圧.　血圧、4(4)、545-551.

須田道雄、田中　清、小川佳宏、八十田明宏、田村尚久、中尾一和（1997）脳性ナトリウム利尿ペプチド(BNP)による成長板軟骨増殖促進作用ーBNP過剰発現マウスを用いた解析ー、日本骨代謝学会雑誌、14(4)、207-214.

循環病態学（Cardiovascular Medicine)

Kihara Y, Inoko M, Hatakeyama N, Momose Y, Sasayama S. Mechanisms of negative inotropic effects of class Ic antiarrhythmic agents: comparative study of the effects of flecainide and pilsicainide on intracellular calcium handling in the dog ventricular myocardium. J.Cardiovasc. Pharmacolog. 27:42-51, 1996.

Morii I, Kihara Y, Konishi T, Inubushi T, Sasayama S. A mechanism of negative force-frequency relationship in the physiologically intact rat ventricualr myocardium: studies by intracellular Ca2+ monitor with indo-1 and by 31P-NMR spectroscopy. Jap. Circ. J. 60:593-603, 1996.

Kihara Y, Inoko M, Sasayama S. Changes of calcium transients during transitions to heart failure: studies in Dahl rat heart failure model. Proceedings of the Fifth Antwerp-La Jolla-Kyoto Research Conference on Cardiac Function. J. Cardiac Failure 2:S113-S120, 1996.

Kihara Y, Inoko M, Sasayama S. Dahl salt-sensitive rats: a new model to study transitions from compensatory hypertrophy to left ventricular failure. In: Sasayama S, ed. Recent Insights into Failing Heart Syndrome. Springer-Verlag, Tokyo, pp105-115, 1996.

Kihara Y, Sasayama S. Myocardial calcium handling during ischemia/reperfusion and its modulation with nisoldipine. In: Sasayama S, Kitabatake A, and Takeshita A, eds. International Nisoldipine Symposium Kyoto '95. Excerpta Medica, Ltd., Tokyo, pp17-29, 1996.

Kihara Y, Inoko M, Sasayama S. Changes of calcium transients during transitions to heart failure: studies in Dahl rat heart failure model. In: Sasayama S, Ross JJr, Brutsaert D, eds. Heart Failure: New Insights into Mechanisms and Management. Churchill Livingstone, Tokyo, pp113-120, 1996.

Furukawa Y, Matsumori A, Hirozane T, Sasayama S. (1996). Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model. Circulation 93:333-339.

Furukawa Y, Matsumori A, Hirozane T, Matsui S, Sato Y, Ono K, Sasayama S. (1996). Immunomodulation by an adenylate cyclase activator, NKH477, in vivo and in vitro. Clin Immunol Immunopathol 79:25-35.

Sasayama S, Matsumori A. (1996). Vesnarinone: A Potential Cytokine Inhibitor. J Cardiac Failure 2:251-258.

Shioi T, Matsumori A, Sasayama S. (1996). Persistent expression of cytokine in the chronic stage of viral myocarditis in mice. Circulation 94:2930-2937.

Okuda K, Nohara R, Ogino M, Tamaki N, Konishi J, Fujita M, Sasayama S (1996). Limitaion of infarct size with preconditioning and calcium antagonist (Diltiazem) - Difference of 99mTc-PYP uptake in the myocardium -. Annals of Nucl. Med., 10, 201-209.

Hosokawa R, Nohara R, Fujibayashi Y, Okuda K, Ogino M, Hata T, Fujita M, Tamaki N, Konishi J, Sasayama S (1996). Metabolic fate of iodine-123-BMIPP in Etomoxir provocated canine myocardium : Implication for SPECT imaging. J Nucl. Med., 37, 1836-1840

Fujibayashi Y, Nohara R, Hosokawa R, Okuda K, Yonekura Y, Tamaki N, Konishi J, Sasayama S (1996). Metabolism and kinetics of I-123-b-methyl-R-iodophenylpentadecanoic acid (BMIPP) in canine myocardium. J Nucl. Med., 37, 757-761

Nohara R, Okuda K, Ogino M, Hosokawa R, Tamaki N, Konishi J, Fujibayashi Y, Yonekura Y, Fujita M, Sasayama S (1996). Evaluation of myocardial viability by 123I-BMIPP imaging : An experimental study with dog. J Nucl. Med., 37, 1403-1407

Muso E, Yoshida H, Takeuchi E, Yashiro M, Matsushima H, Oyama A, Suyama K, Kawamura T, Kamata T, Miyawaki S. (1996). Enhanced production of glomerular extracellular matrix in a new mouse strain established by selective mating of high serum IgA ddY (HIGA) mice. Kidney Int 50:1946-1957.

木原康樹：心不全の成因と対策：ダール食塩感受性ラットを用いた新しい心不全移行モデルの開発とその左室心筋収縮特性。循環器専門医4(2):199-204,1996.

木原康樹：不全心筋でのカルシウムハンドリング、「心臓病診療プラクティス」シリーズ １１：心筋症を知る、文光堂、pp204-210, 東京、1996.

木原康樹：不全心の細胞内カルシウム調節機構。Heart View 1(1): 78-83,1996.

王衛中、松森昭、岡田幾太郎、佐藤幸人、篠山重威 （1996). ウイルス性心筋炎による心不全モデルにおけるカルシウム拮抗薬の効果. 　厚生省特定疾患特発性心筋症調査研究班平成7年度研究報告集, pp.160-164.

松森昭（1996). マウス拡張型心筋症モデルにおけるサイトカイン発現の検討.　循環器病研究振興財団, 1995 (平成7) 年度研究助成業績報告集、pp.49-52.

陶山勝郎，櫻井眞里，川村貴秀，鎌田　正，大山敦嗣，小野孝彦，武曾恵理，篠山重威 (1996). 悪性巣状糸球体硬化症モデルに対するACE阻害剤投与時の血清脂質の検討.　第９回腎と脂質研究会講演記録集.

Hisamatsu Y, Ohkusa T, Kihara Y, Inoko M, Ueyama T, Yano M, Sasayama S, Matsuzaki M. Early changes in the functions of cardiac sarcoplasmic reticulum in volume-overloaded cardiac hypertrophy in rats. J. Mol.Cell Cardiol. 29:1097-1109,1997.

Shioi T, Matsumori A, Kihara Y, Inoko M, Ono K, Iwanaga Y, Yamada T, Iwasaki A, Matsushima K, Sasayama S. Increased expression of interleukin-1? and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. Circ. Res. 81:664-671,1997.

Takagi S, Kihara Y, Wang Z, Mitsuie T, Noma A, Sasayama S. Effects of tilisolol, a non-selective beta-adrenergic bolocker, on the membrane currents of the isolated guinea-pig ventricular myocyte. J. Cardiovascular Pharmacol. 29:593-598,1997.

Kihara Y, Sasayama S. Transition from compensatory hypertrophy to dilated failing left ventricle in Dahl-Iwai salt-sensitive rats. Am. J. Hypertens. 10:78S-82S, 1997.

Kihara Y. The anti arrhythmic effects and the negative inotropic effects of class Ic agents do not share the common underlying mechanism: the interaction with L-type calcium channel is important for the contractile suppression in diseased hearts. Ion Channel Modulators ID Research Alert. 2:285-288, 1997.

木原康樹、篠山重威：カルシウムセンシタイザーの臨床。Annual Review 循環器 1997, 中外医学社、東京、pp78-82,1997.

木原康樹：細胞内カルシウムハンドリング：不全心におけるカルシウム動態。篠山重威 編、 心不全、 医薬ジャーナル社、pp152-163, 1997.

木原康樹：心筋のカルシウムハンドリングと収縮弛緩特性。Cardiologist 2(6):411-418,1977.

木原康樹：不全心筋のカルシウムハンドリング。Clinical Calcium 7(11):1483-1488, 1977.

塩井哲雄、松森昭（1997).ウイルス性心筋炎による心臓リモデリングとサイトカイン循環器. Today, Vol.1, 6: 660-664.

野原　隆司、細川了平、奥田和美、萩野幹也、藤田正俊、玉木長良、藤林康久、篠山重威　（1997）.　１２３I-BMIPPの取り込みの機序　ー動物実験による検討ー.　心臓,　29(suppl 1), 16-21.

牧野利明，小野孝彦，武曾惠理，篠山重威，本多義昭 (1997).：ddYマウス自然発症IgA腎症モデルを用いた紫蘇の糸球体腎炎抑制作用の検討.　和漢医薬学雑誌, 14, 420-421.　

武曾惠理 (1997). III. 腎炎・ネフローゼ　2. IgA腎症の動物モデル.　Annual Review 腎臓 1997，長沢俊彦編，中外医学社，東京，pp. 52-56.

Wang W-Z, Matsumori A, Yamada T, Shioi T, Okada I, Matsui S, Sato Y, Suzuki H, Shiota K, Sasayama S. (1997). Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis: A possible mechanism through inhibition of nitric oxide production. Circulation 95:245-251.

Hirozane T, Matsumori A, Furukawa Y, Matsui S, Matoba Y, Sasayama S. (1997). Prolongation of murine cardiac allograft survival with vesnarinone. J Mol Cell Cardiol 29:67-76.

Ono K, Matsumori A, Shioi T, Furukawa Y, Sasayama S. (1997). Enhanced expression of hepatocyte growth factor/c-met by myocardial ischemia and reperfusion in a rat model. Circulation 95:2552-2558.

Matsumori A, Ono K, Nishio R, Igata H, Shioi T, Matsui S, Furukawa Y, Iwasaki A, Nose Y, Sasayama S. (1997). Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain. Circulation 96:1501-1506.

Shioi T, Matsumori A, Kihara Y, Inoko M, Ono K, Iwanaga Y, Yamada T, Iwasaki A, Matsushima K, Sasayama S. (1997). Increased expression of interleukin-1b and monocyte chemotactic and activating factor MCAF)/ monocyte chemoattractant protein-1(MCP-1) in the hypertrophied and failing heart with pressure overload. Circ Res 81:664 -671.

Shioi T, Matsumori A, Ono K, Nishio R, Kakio T, Sasayama S. (1997). Protective role of Interleukin-12 in viral myocarditis. J Mol Cell Cardiol 29:2327-2334.

Hosokawa R, Nohara R, Fujibayashi Y, Okuda K, Ogino M, Hata T, Fujita M, Tamaki N, Konishi J, Sasayama S (1997). Myocardial kinetics of BMIPP in canine myocardium after regional ischemia and reperfusion : Implications for clinical SPECT imaging of ischemic heart disease. J Nucl. Med., 38, 1857-1863

Oyama A, Muso E, Matsushima H, Yashiro M, Miyawaki S, Yoshida H, Sasayama S. (1997). Upregulated TGF-β mRNA expression in the spleen T cells of high IgA prone inbred (HIGA) mice, a murine model of IgA nephropathy with glomerulosclerosis. Kidney Int 53: 880-891.

Ozaki K, Takada N, Tsujimoto K, Tsuji N, Kawamura T, Muso E, Ohta M, Itoh N. (1997). Localization of insulin receptor-related receptor in the rat kidney. Kidney Int 52: 694-698.

Haku E, Muso E, Nogaki F, Sakurai M, Kawamura T, Kamata T, suyama K, Oyama A, Ono T, Sasayama S, Nishimoto E, Yoshimoto M, Uno K, Kishida T. (1997).Whole-Blood interferon-producing capacity in IgA nephropathy patients. Nephrology 3 (supple):A14.

Miyawaki S, Muso E, Takeuchi E, Matsushima H, Shibata Y, Sasayama S, Yoshida H . (1997). Selective breeding for high serum IgA levels from noninbred ddY mice: Isolation of a strain with an early onset of glomerular IgA deposition. Nephron 76: 201-207.

消化器病態学 (Gastroenterology and Hepatology)

Yuko Kono, Fuminori Moriyasu, Yoshitaka Mine, Takayuki Nada, Naohisa Kamiyama, Yoshiki Suginoshita, Takeshi Matsumura,Kyoko kobayashi, Tsutomu Chiba (1997). Gray scale second harmonic imaging of the liver with galactose-based microbubbles. Investigative Radiology, 32, 2, 120-125

Yuko Kono, Fuminori Moriyasu, Takayuki Nada, Yoshiki Suginoshita, Takeshi Matsumura, Kyoko Kobayashi, Takefumi Nakamura, Tsutomu Chiba (1997). Gray scale second harmonic imaging of the liver：A Preliminary animal study, Ultrasound in Medicine and Biology, 23, 5, 719-726

Takayuki Nada, Fuminori Moriyasu, Yuko Kono, Yoshiki Suginoshita,Takeshi Matsumura,Kyoko Kobayashi, Takefumi Nakamura, Tsutomu Chiba (1997). Sonographic detection of tumor blood flow using a new contrast agent in woodchuck hepatomas, Journal of Ultrasound in Medicine, 16, 485-491

成人・老年病病態学分野 (Geriatric Medicine)

松永洋一、若月芳雄、伊藤俊之、吉田優、金子至津佳、臼井崇、北徹 (1996) 小腸上皮間CD4陽性Ｔ細胞の機能解析 消化器と免疫、33, 7-10

若月芳雄 (1997) 消化管の分子生物学　−消化器とリンパ球 先端医学社　G.I. Research, 4, 540-545

伊藤俊之、吉田優、臼井崇、松永洋一、金子至津佳、北徹、千葉勉、若月芳雄 (1997) Helicobactor pylori感染胃粘膜浸潤細胞の機能解析 消化器と免疫 34,41-44

Takashi Usui, Yoshio Wakatsuki, Y. Matusnaga, S. Kaneko, H. Koseki, and T. Kita (1997) Over expression of B cell specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to a Ig high producer cell with plasma cell phenotype. J. Immunol,158, 3197-3204

臨床病態検査学分野 (Laboratory Medicine)

Ihara C, Shimatsu A, Mizuta H, Murabe H, Nakamura Y, Nakao K (1996) Decreased neurotorophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats. Neuropeptides, 30, 309-312.

上田路子、須川秀夫、小杉眞司、森　徹 (1997)　モノクローナル抗TSH受容体抗体の示す生物活性と認識エピトープの解析　日本内分泌学会雑誌、73,263

発達小児科学分野 (Pediatrics)

服部春生、早川孝裕（1996）．新生仔低酸素性虚血性脳障害に対するゾニサミドの脳保護作用．ゾニサミドの世界ー単剤療法と薬理作用の新知見ー、pp64-69、八木和一、関　亨監修、ライフサイエンス出版、東京．

Higuchi, Y., Hattori, H., Hattori, R., and Furusho, K. (1996). The increase of the neurons containing neuronal nitric oxide synthase in the brain of a neonatal hypoxic-ischemic rat model. Brain Dev., 18, 369-375.

樋口嘉久、服部春生、辻　雅弘、古庄卷史、服部隆一、奥野武彦（1997）．新生仔ラット低酸素性虚血性脳症における神経型一酸化窒素合成酵素含有ニューロンの増加．Brain Hypozia, 11, 11-18

核医学・画像診断学分野 (Nuclear Medicine and Diagnostic Imaging)

Kobayashi, H., Sakahara, H., Endo, K., Yao, Z-S., Konishi, J. (1996). Inflammation-seeking scintigraphy with radiolabeled biotinylated polyclonal IgG followed by the injection of avidin chase. Nucl. Med. Biol., 23, 29-32.

Arano, Y., Wakisaka, K., Mukai, T., Uezono, T., Motonari, H., Akizawa, H., Kairiyama, C., Ohmomo, Y., Tanaka, C., Ishiyama, M., Sakahara, H., Konishi, J., Yokoyama, A. (1996). Stability of a metabolizable ester bond in radioimmunoconjugate. Nucl. Med. Biol., 23, 129-136.

Arano, Y., Uezono, T., Akizawa, H., Ono, M., Wakisaka, K., Nakayama, M., Sakahara, H., Konishi, J., Yokoyama, A. (1996). Reassessment of diethylenetriaminepentaacetic acid (DTPA) as a chelating agent for indium-111 labeling of polypeptides using a newly synthesized monoreactive DTPA derivative. J. Med. Chem., 39, 3451-3460.

Arano, Y., Wakisaka, K., Ohmomo, Y., Uezono, T., Akizawa, H., Nakayama, M., Sakahara, H., Tanaka, C., Konishi, J., Yokoyama, A. (1996). Assessment of radiochemical design of antibodies using an ester bond as the metabolizable linkage: evaluation of maleimidoethyl 3-(Tri-n-butylstannyl) hippurate as a radioiodination reagent of antibodies for diagnostic and therapeutic applications. Bioconjugate Chem., 7, 628-637.

Zhang, M., Sakahara, H., Yao, Z., Saga, T., Nakamoto, Y., Sato, N., Nakada, H., Yamashina, I., Konishi, J. (1997). Intravenous avidin chase improved localization of radiolabeled streptavidin in intraperitoneal xenograft pretargeted with biotinylated antibody. Nucl. Med. Biol., 24, 61-64.

Fujibayashi, Y., Tajima, N., Wada, K., Waki, A., Sakahara, H., Konishi, J., Yonekura, Y. (1997). Radioiodinated alpha-p-iodophenyl-N-tert-butylnitrone as a radical detecting agent in vivo. Nucl. Med. Biol., 24, 399-403.

Saga, T., Sakahara, H., Yao, Z., Nakamoto, Y., Sato, N., Hattori, N., Zhang, M., Zhao, S., Aoki, T., Miyatake, S., Namba, Y., Konishi, J. (1997). Detection of altered adhesion molecule expression in experimental tumors by a radiolabeled monoclonal antibody. Jap. J. Cancer Res., 88, 1171-1180.

藤林康久、中川加寿夫、脇　厚生、阪原晴海、小西淳二、横山　陽 (1997). 111In標識アンチセンス核酸による腫瘍イメージングの可能性に関する検討．合成、安定性、体内分布．核医学、33、115-122.

阪原晴海 (1997). 癌の体腔内播種に対する選択的内照射療法の開発．平成8年度がん重点研究報告集録、716-717, 1997.

移植免疫分野 (Transplantation and Immunology)

Y. Inomata, K.Tanaka, H.Okajima, S.Uemoto, N.Ozaki, H.Egawa, K.Satomura, T.Kiuchi, Y.Yamaoka Living related liver transplantation for children younger than one year old European J. Pediatric surgery 6, 3, 148-151 1996

K.Kimura, Y Inomata Chapter 55 Biliary atresia. 32/1〜32/13 in "Abdominal Surgery of Infancy and Childhood" edited by W.L.Donellan., K.Kimura, JC.Schafer, JJ White. Harwood Academic Publishers, Luxembourg 1996

Y.Inomata, K.Kimura. Chapter 56 Choledochal cyst. 33/1〜33/13 in "Abdominal Surgery of Infancy and Childhood" edited by W.L.Donellan., K.Kimura, JC.Schafer, JJ White. Harwood Academic Publishers, Luxembourg 1996

Y.Inomata, K.Kimura. Chapter 60 Benign and Malignant Hepatic Tumors. 60/1〜60/15 in "Abdominal Surgery of Infancy and Childhood" edited by W.L.Donellan., K.Kimura, JC.Schafer, JJ White. Harwood Academic Publishers, Luxembourg 1996

Y.Inomata, K.Tanaka, H.Egawa, S.Uemoto, N.Ozaki, H.Okajima, K.Satomura, Y.Yamaoka, T.Hashida Evolution of immunosuppression with FK506 in pediatric living related liver transplantation. Transplantation 61 2 247-252 1996

A.Tanaka, K.Tanaka, A.Tokuka, T.Kitai, H.Shinohara, E.Hatano, S.Sato, T.Inomoto, Y.Takada, H.Higashiyama, Y.Nakamura, Y.Yamamoto, H.Egawa, S.Uemoto, I.Ikai, N.Ozaki, Y.Inomata, Y.Yamaoka Graft size-matching in living related partial liver transplantation in relation to tissue oxygenation and metabolic capacity. Transplantation International 9 15-22 1996

S.Hasegawa, K.Tanaka, H.Egawa, Y.Inomata, M.Murakawa, Y.Terada, T.Matsui, T.Arai, Y.Yamaoka, K.Mori Perioperative respiratory management with fiberoptic bronchoscopy in pediatric living-related liver transplantation Surgery 119 198-2011996

I.Ikai, T.Morimoto, Y.Yamamoto, Y.Takada, Y.Nakamura, H.Higashiyama, T.Kitai, H.Egawa, A.Tanaka, K.Tanaka, Y.Yamaoka Left lobectomy of the Donor: Operation for larger recipients in living related liver transplantation Transplantation Proceedings 28 1 56-58 1996

S.Hasegawa, K.Tanaka, Y.Inomata, M.Murakawa, Y,Yamaoka, K.Mori Six cases of tracheobronchomalacia complicated with perioperative courses of pediatric living-related liver transplantation Transplant Proc. 28 3 1679 1996

T.Inomoto, F.Nishizawa, H.Sasaki, H.Terajima, Y.Shirakata, S.Miyamoto, I.Nagata, M.Fujimoto, F.Moriyasu, K.Tanaka, Y.Yamaoka Experiences of 120 microsurgical reconstructions of hepatic artery in living related liver transplantation Surgery 119 1 20-26 1996

K.Satomura,N.Ozaki,H.Egawa,S.Uemoto,Y.Inomata,K.tanaka,Y.Yamaoka,T.Hashida,M.Yasuhara,and K.Inui Pharmacokinetics of FK 506 in Living-Related Liver Transplantaion.Transplantation Proceedings 28 2 1005 1996

H.Egawa, K.Tanaka, Y.Inomata, S.Uemoto, H.Okajima, K.Satomura, T.Kiuchi, S.Yabe, H.Nishizawa, Y.Yamaoka Auxiliary partial orthotopic liver transplantation from a living related donor: A report of two cases Transplantation Proceedings 28 2 1071-1072 1996

T.Morimoto, M.Ichimiya, A.Tanaka, I.Ikai, Y.Yamamoto, Y.Nakamura, Y.Takada, Y.Inomata, K.Honda, T.Inamoto, K.Tanaka, Y.Yamaoka Guidelines for donor selection and an overview of the donor operation in living related liver transplantation Transplant. Int 9 208-213 1996

E.Yamamoto, K.Honda, K.Tanaka, M.Awane, R.Takeda, S.Fukushima, S.Uemoto, T.Inamoto, K.Ishizaki, M.Ikenaga, Y.Yamaoka Evaluating the significance of HLA class II genotypematching in living-related liver transplantation Transplant. Immuno. 4 144-150 1996

S.Hasegawa,K.Tanaka,Y.Inomata,M.Murakawa,Y.Yamaoka,andK.Mori Analysis of Perioperative Respiratory Complications in 100 Consecutive Cases of Pediatric Living-Related Donor Liver Transplantation Transplantation Proceedings 28 3 1673 1996

M.Hagihara,H.Yabe,S.Kato,SHiraga,T.Sato,Y.Inomata,K.Tanaka,Y.Yamaoka,
K.Tsuji Dramatic Change of Soluble HLA Class I Band Patterns After Liver or Bone Marrow Transplantation Transplantation Proceedings 28 3 1754-1755 1996

K.Shimizu,K.Ido,K.Tanaka,T.Nakamura Total spondylectomy and Spinal Shortening for giant-cell tumor of spine THE LANCET 348 9023 342 1996

T. Kiuchi, K.Tanaka, Y.Inomata, S.Uemoto, K.Satomura, H.Egawa, K.Sano, H.Okajima, Y.Yamaoka Experience of Tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampcin and side effects. Transplantation Proc. 28 6 3171-3172 1996

H. Egawa, K. Tanaka, Y. Inomata, N. Ozaki, S. Uemoto, H.Okajima, K.Satomura, Y. Yamaoka Surgical techniques and results of hepatic vein reconstruction in 125 living-related donor liver transplants Transplantation Proc. 28 3 1661-1662 1996

H.Sawada, S.Kaihara, H.Egawa, Y.Inomata, K.Tanaka, Y.Yamaoka Efficacy of a new immunosuppressant CAM on small bowel transplantation in rats. Transplantation Proceedings 28 5 2512-2513 1996

S.Uemoto, Y.Inomata, K.Tanaka, N.Ozaki, H.Egawa, H.Okajima, H.Nishizawa, S.Yabe, Y.Yamaoka Living related liver transplantation in children with hypoxemia related to intrapulmonary shunting Transplant Int. 9 [Suppl 1] S157-159 1996

T.Torizuka,N.Tamaki,T.Fujita,Y.Yonekura,S.Uemoto,K.Tanaka,Y.Yamaoka,J.Konisi Focal Liver Hyperplasia in Alagille Syndrome:Assessment with Hepatoreceptor and Hepatobiliary Imaging Journal of Nuclear Medicine 37 8 1365-1367 1996

H.Shinohara,E.Hatano,S.Kitai,T.Inomoto,A.Nishizawa,A.Kanazawa,S.Uemoto,Y.Inomata,K.Tanaka,Y.Yamaoka, Anatomical and physiological problems of Segment IV;liver taransplants using left lobes from living related donors Clinical transplantation 10 341-347 1996

E.Hatano,A.Tanaka,H.Shinohara,T.Kitai ,S.Satoh,K.Tanaka,Y.Yamaoka Superiority of HTK Soulution to UW Solution for Tissue Oxygenation in Living Related Liver Trransplantation Transplantation Proceedings 28 3 1880-1881 1996

A.Tanaka, K.Tanaka, H.Shinohara, E.Hatano, S.Sato, A.Kanazawa, T.Kitai, H.Higashiyama, Y.Nakamura, Y.Yamamoto, H.Okajima, H.Egawa, I.Ikai, S.Uemoto, I.Satomura, N.Ozaki, Y.Inomata, Y.Yamaoka Extension of the indication for living related liver transplantaiton from children to adults based on resolution of graft size mismatch in relation to tisuue oxygenation and metabolic load: a case report Transplant Int. 9 [Suppl 1] S174-177 1996

T.Kitai, H.Higashiyama, Y.Takada, Y.Yamamoto, Y.Nakamura, I.Ikai, A.Tanaka, K.Tanaka, Y.Yamaoka Pulmonary embolism in a donor of living-related liver transplantation: Estimation of donor's operative risk Srgery 120 3 570-573 1996

A.Inui, T.Fujisawa, H.Komatsu, K.Tanaka, M.Inui Histological improvement in native liver after auxiary partial liver transplantation for ornithine transcarbamilase deficiency The Lancet 348 14 751-752 1996

A.Tokuka, T.Kitai, A.Tanaka, N.Yanabu, B.Sato, S.Mori, T.Inomoto, H.Shinohara, Y.Yamaoka, S.Uemoto, K.Tanaka, H.Someda, M.Fujimoto, F.Moriyasu Analysis of factors affecting the graft oxygenation state in living related liver transplantation. Hepato-Gastroenterology 43 1203-1211 1996

T.Kitai, H.Shinohara, E.Hatano, S.Sato, A.Kanazawa, S.Tsunekawa, M.Yamamoto, Y.Yamaoka, S.Uemoto, Y.Inomata, K.Tanaka, A.Tanaka Postoperative monitoring of the oxygenation state of the graft liver in cases with hepatopulmonary syndrome Transplantaiton 62 11 1676-1678 1996

A.Matsui,Y.Arakawa,T.Momoya,N.Sasaki,S.Kawasaki,K.Tanaka Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation Acta Paediatrica Japonica 38 699-701 1996

S.Hasegawa, K.Mori, Y.Inomata, M.Murakawa, Y.Yamaoka, K.Tanaka Factors associated with postoperative respiratory complications in pediatric liver transplantation from living-related donors Transplantaiton 62 7 943-947 1996

M.Yamazato, K.Kimura, H.Yoshino, Y.Inomata, R.T.Soper Bipolar electrode implantation for myoelectrical recordings of rat bowel Digestive and Sciences 41 7 1310-1312 1996

岡島英明、猪股裕紀洋、江川裕人、横井暁子、里村一成、上本伸二、田中紘一、山岡義生 1歳未満の生体肝移植の検討 今日の移植 9(2) 141-146 1996

財間正純、永松馨介、光吉明、田中紘一 Hirchsprung 病根治療後19年目に発症した吻合部巨大肉芽種の1例 小児外科 28 4 1996

田中紘一 生体部分肝移植 内科（臨床雑誌） 77（6） 1087- 1996

小松陽樹、乾あやの、大川貴司、宮川芳宏、藤沢知雄、上本伸二、猪股裕紀洋、田中紘一 生体部分肝移植にて救命し得た溶血発作を伴う劇症肝炎型のWilson病(Wilsonian fulminant hepatitis)の1女児例 肝臓 37（4） 244-249 1996

上本伸二、田中紘一 生体肝移植の現況 消化器外科 19 1389-1396 1996

猪股裕紀洋、尾池文隆、岡本晋也、川島真由美、上本伸二、阿曽沼克弘、田中紘一 胆道閉鎖症肝移植症例での拒絶反応の早期発見 小児外科 28 852-858 1996

猪股裕紀洋、田中紘一 胆道閉鎖症治療としての肝移植 日本外科学会 97 8 1996

木内哲也、三宅　洋、小倉靖弘、笠原群生、田中紘一 生体肝移植における真菌症 臨床と微生物 23 569-574 1996

辻邦彦、渡辺晴司、北沢俊治、佐藤育子、姜貞憲、柳田健司、洞田克巳、前久保博士、田中明、田中紘一、山岡義生 成人間生体部分肝移植を施行した原発性胆汁性肝硬変の1例 肝臓 37 5 1996

中島一朗、渕之上昌平、阿部正浩、小池太郎、北島久視子、赤松　真、船越陽一、藤田省吾、河合達郎、太田和夫、高崎　健、橋本悦子、斉藤明子、林　直諒、白髪宏司、伊藤克己、田中紘一 劇症肝炎（急性肝不全）に対する生体肝移植 移植 31 334-345 1996

加藤悠太郎、田中紘一、猪股裕紀洋、上本伸二、阿曽沼克弘、貝原聡、横井暁子、尾池文隆、岡本晋弥生体肝移植における医学的課題 消化器科 23（5） 479-483 1996

田中紘一、猪股裕紀洋、上本伸二、阿沼曽克弘、木内哲也 部分肝移植 Frontiers in Gastroenterology 7 35-41 1996

田中紘一 生体ドナーを用いた自己肝温存部分肝移植の研究 南江堂　外科 58 1873-1876 1996

藤本康弘、上本伸二、阿曽沼克弘、猪股裕紀洋、田中紘一 小腸移植レシピエントの術前後の栄養管理メディカル・コア 18 11 1996

阿曽沼克弘、瓜生原健嗣、田中紘一 移植外科　-生体肝移植の課題と今後の展望- 外科診療 38（12） 1391-1395 1996

T. Kiuchi, Y.Inomata, S.Uemoto, K, Satomura, H.Egawa, H.Okajima, Y.Yamaoka, K.Tanaka A hepatic graft tuberculosis tranplanted from a living-related donor. Transplantation. 63 6 905-907 1997

S.Kaihara, H.Egawa, Y.Inomata, S.Uemoto, K.Asonuma, K.Tanaka Serotonin as a useful parmeter for cold and warm ischemic injury in small bowel transplantation. Transplantaiton 64 (3) 405-410 1997

S.Uemoto, Y.Inomata, H.Egawa, K.Satomura, T.Kiuchi, H.Okajima, K.Asonuma, K.Sano, S.Uyama, K.Tanaka Effects of hypoxemia on early postoperative course of liver transplantaiton in pediatric patients with intrapulmonary shunting. Transplantaiton 63 3 407-414 1997

Y.Inomata, K.Tanaka, H.Egawa, S.Uemoto, T.Kiuchi, K.Satomura, S.Uyama, H.Okajima Application of a tissue expander for stabilizing graft position in living related liver transplantaiton Clinical transplantaiton 11 1 56-59 1997

K.Tanaka, Y.Inomata Present status and prospects of living related liver transplantation. J.HepatoBiliary pancreatic Surgery 4 51-70 1997

T.Kiuchi,H.J.Schlitt,K.J.Oldhafaer,B.nashan,A.Tanaka,K.Wonigeit,B.Ringe,K.Tanaka,Y.Yamaoka,R.Pichlmayr Early Acute Rejection After Hepatic Graft Reperfusion:Association With lschemic Injury With Good Function,Oxygenation Heterogeneity,and Leukocyte Adhesion Without Aggregation Transplantation proceedings 29 364-365 1997

H.Egawa,Y.Inomata,S.Uemoto,K.Asonuma,T.Kiuchi,H.Okajima,Y.Yamaoka, K.Tanaka Hepatic vein reconstruction in 152 living-related donor liver transplantation patients Surgery 121 3 250-257 1997

S.Uemoto,S.Yabe,Y.Inomata,H.Nishizawa,K.Asonuma,H.Egawa,T.Kiuchi,H.Okajima,Y.Yamaoka,H.Yamabe, A.Inui,T.Fujisawa,K.Tanaka Coexistence of a graft with the preserved native liver in auxiliary partial orthotopic liver transplantation from a living donor for ornithine transcarbamylase deficiency transplantation 63 7 1026-1028 1997

H.Azuma,K.Sasaki,K.Miyamoto,K.Tanaka,H.Kato,S.Uemoto,A.Okuno Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy Acta Pediatrica Japonica 39 222-225 1997

Y.Inomata,f.Oike,S Okamoto,S uemoto ,K Asonuma ,H Egawa,T Kiuchi,H Okajima,K Tanaka Impact of the Development of a Liver Transplant Program on the Treatment of Biliary Atresia in an Institution in Japan Journal of Pediatric Surgery 32 8 1201-1205 1997

E.Hatano,T.Kiuchi,A Tanaka,H Shinohara,T Kitai,S Satoh,T Inomoto,H Egawa,S Uemoto,Y Inomata,H Lang,K Oldhafer,B Ringe R Pichlmayr,K Tanaka,Y Yamaoka Hepatic preservation with histidine-tryptophan-ketoglutarate solution in living-related and cadaveric liver transplantation Clincal Science 93 81-88 1997

H.Nishizawa,H.Egawa,Y.Inomata,S.Uemoto,K.Asonuma,T.Kiuchi,y.Yamaoka,K.Tanaka Efficiency of Pentoxifylline in Donor Pretreatment in Rat Liver Transplantation. Journal of Surgical Research 72 170-176 1997

M.Ueda,K.Tanaka Choosing an Immunosuppressive Regimen for Liver Transplantation BioDrugs 8 6 430-438 1997

N.Shinkura,I.Ikai,H.Egawa,A.Yamauchi,Y.Kawai,Y.Inomata,T.Inamoto,K.Tanaka,Y.Yamaoka Presence of ANTI-FKBP12 Autoantibodies in Patients with Liver Allografts Transplantation 64 9 1336-1342 1997

T.Kiuchi,Y.Inomata,S.Uemoto,K.Asonuma,H.Egawa,M.Hayashi,S.Fujita,K.Tanaka Living-donor Liver Transplantation in Kyoto,1997 Clinical Transplants 91-198 1997

E.Hatano,H.Terajima,S.Yabe,K.Asonuma,H.Egawa,T.Kiuchi,S.Uemoto,Y.Inomata,K.Tanaka,Y.Yamaoka Hepatic Artery Thrombosis in Living Related Liver Transplantation. Transplantation 64 (10) 1443-1446 1997

清益功浩、藤永英志、老木美帆、瀬戸嗣郎、藤澤一朗、山下幸孝、田中紘一 先天性食道再狭窄に対してバルーンカテーテル拡張術が有効であった1例 金原出版株式会社　小児科 38（1） 91-94 1997

田中紘一、木内哲也 臓器移植 新外科学大系　追補4小児外科、形成外科（中山書店） 105-112 1997

田中紘一 生体肝移植の現状と課題 肝臓 38 1 1997

寺嶋宏明、田中紘一、波多野悦朗、矢部真一、猪股裕紀洋、上本伸二、江川裕人、木内哲也、岡島英明、山岡義生 生体部分肝移植術における血管外科手技の応用 日血外会誌 6（3） 63-69 1997

猪股裕紀洋・田中紘一 免疫抑制療法 Pharma Medica 15 27-35 1997

乾あやの、藤沢知雄、茂木陽、松本浩、宮川芳宏、小松陽樹、関根勇夫、吉岡重威、上本伸二、猪股裕紀洋、田中紘一 生体部分肝移植を行ったオルニチントランスカルバミラー欠損症の1例 日本小児外 科雑誌 101　5 963-967 1997

田中紘一・猪股裕紀洋 胆道閉鎖症の治療-葛西手術と生体肝移植 消化器外科 20 1241-1245 1997

猪股裕紀洋、藤本康弘、貝原聡、上本伸二、三宮彰仁、田中紘一 生体小腸移植の経験から 今日の移植 10（4）537-543 1997

田中紘一 生体肝移植の現状と課題 今日の移植 10 4 1997

猪股裕紀洋、阿曽沼克弘、瓜生原健嗣、松川啓義、笠原群生、田中紘一 胆道閉鎖症再手術と肝移植 小児外科 29 7 1997

田中紘一、猪股裕紀洋 胆道閉鎖症の治療-葛西手術と生体肝移植 へるす出版 20 8 1997

松川啓義、阿曽沼克弘、田中紘一 肝移植 臨床検査 41（8） 903-906 1997

松川啓義、阿曽沼克弘、田中紘一 肝移植 臨床検査 41（8） 903-906 1997

木内哲也、藤本康弘、田中紘一 肝移植による肝癌治療 臨床雑誌　内科 80（4） 721-725 1997

田中紘一 移植と感染 今日の移植 10（5） 684 1997

木内哲也・枝元良広・首村智久・武市卒之・猪股裕紀洋・田中紘一 実質臓器移植における細菌感染症 今日の移植 10（5） 685-691 1997

田中紘一 肝移植と感染症 小児外科 29（9） 1141 1997

木内哲也・枝元良広・首村智久・武市卒之・猪股裕紀洋・田中紘一 胆道閉鎖症生体肝移植例での細菌・真菌感染症対策-特に本邦症例の特殊性について- 小児外科 29（9） 1177-1182 1997

横井暁子・猪股裕紀洋・上本伸二・阿曽沼克弘・田中紘一 生体肝移植 金原出版株式会社 38（10） 1291-1299 1997

萩野英朗、月岡幹雄、里村吉威、中川彦人、鵜浦雅志、三輪淳夫、中沼安二、田中紘一、山岡義生 生体部分肝移植を施行した劇症肝炎亜急性型の1例 肝臓 38（8） 30-34 1997

田中紘一・猪股裕紀洋 肝移植定着化への医学的課題-生体肝移植を踏まえて- 中外出版 367-370 1997

上本伸二、田中紘一 小腸移植 小児内科 29 10 1997

上本伸二、猪股裕紀洋、阿曽沼克弘、江川裕人、木内哲也、田中紘一 生体肝移植とEBウイルス関連腫瘍 小児がん 34（2） 223-227 1997

猪股裕紀洋、田中紘一 生体肝移植の基礎と臨床 小児科臨床 50 2530-2540 1997

中山信吾、石塚豪、虻川大樹、松井陽、沼崎典明、近岡秀二、関口恵、橋本剛、佐藤都留雄、田名部宗之、工藤正文、山邊博彦、江川裕人、上本伸二、猪股裕紀洋、田中紘一 生体肝移植にて救命された新生児単純ヘルペスウイルス劇症肝炎の1例 小児科臨床 50 2557-2562 1997

松倉規、川島真由美、内山秀昭、海掘昌樹、木内哲也、阿曽沼克弘、上本伸二、猪股裕紀洋、田中紘一生体部分肝移植の治療成績 小児内科 29 12 1997

田中紘一、阿曽沼克弘 生体肝移植術 へるす出版 20（7） 1060-1069 1997

田中紘一 小腸移植 日医雑誌 119（11） 1768 1997

猪股裕紀洋、上本伸二、丸澤宏之、江川裕人、木内哲也、林　道廣、田中紘一 肝炎マーカー陽性例に対する肝移植の問題と対策 小児内科　 29（12） 1659-1663 1997

消化器外科学分野 (Gastroenterological Surgery)

S. Mashima, G. Shirakami, A. Mitsuyoshi, M. Nakagami, T. Morimoto, M. Terasaki, K. Nakao, H. Yamabe, Y. Yamaoka, K. Ozawa; Evaluation of the protective effect of a novel prosracycline analog on mesenteric circulation following warm ischemia. Eur Surg Res, 28: 14-25, 1996.

H. Shinohara, A. Tanaka, T. Kitai, N. Yanabu, T. Inomoto, S. Satoh, E. Hatano, Y. Yamaoka, K. Hirao; Direct measurement of hepatic indocyanine green clearance with near-infrared spectroscopy : Separate evalution of uptake and removal. Hepatology, 23 (1):137-144, 1996.

M. Nakagami, T. Morimoto, A. Mitsuyoshi, S. Mashima, T. Shimabukuro, Y. Yamaoka.; Difference in onset of warm ischemia and reperfusion injury between parenchymal and endothelial cells of the liver. J Surg Res, 62: 118-124,1996.

H. Terajima, T. Yagi, Y. Shirakata, H. Shinohara, S. Satoh, Y. Arima, S. Mashima, T. Hirose, T. Gomi, I. Ikai, T. Morimoto, T. Inamoto, Y. Yamaoka.; Assessment of hyaluronate clearance and endothelin production during extracorporeal xenogeneic pig liver perfusion. Transplant Proc.,28 (2): 633-634, 1996.

S. Satoh, A. Tanaka, E. Hatano, T. Inomoto, S. Iwata, T. Kitai, H. Shinohara, S. Tsunekawa, B. Chance, Y. Yamaoka.; Energy metabolism and regeneration in transgenic mouse liver expressing creatine kinase after major hepatectomy. Gastroenterology, 110: 1166-1174, 1996

T. Yagi, H. Terajima, S. Mashima, Y. Shirakata, H. Shinohara, Y. Arima, T. Gomi, T. Hirose, S. Sato, N. Nakagami, T. Morimoto, N. Ozaki, I. Ikai, T. Inamoto, Y. Yamaoka; Discordant effects of xenogeneic pig liver perfusion on function of sinusoidal endothelial cells and parenchymal cells. Transprant Proc, 28 (3):1402-1403, 1996.

E. Hatano, A. Tanaka, S. Iwata, S. Satoh, T. Kitai, S. Tsunekawa, T. Inomoto, H. Shinohara, B. Chance, Y. Yamaoka;Induction of Endotoxin tolerance in transgenic mouce liver expressing creatine kinase. Hepatology, 24 (3): 663-669, 1996.

M. Kume, Y. Yananoto, S. Saad, T. Gomi, S. Kimoto, T. Shimabukuro, T. Yagi, M. Nakagami, Y. Takada, T. Morimoto, Y. Yamaoka; Ischemic preconditioning of the liver in rats: Implications of heat shock protein induction to increase tolerance of ischemia-reperfusion injury.J. lab. Clin. Med., 128 (3): 251-258,1996.

H. Shinohara, A. Tanaka, T. Fujimoto, E. Hatano, S. Satoh, K. Fujimoto, T. Noda, C. Ide, Y. Yamaoka; Disorganization of microtubular network in postischemic liver dysfunction: its functional and morphological changes. Biochem Biophys Acta, 1317: 27-35, 1996.

H. Terajima, Y. Shirakata, T. Yagi, S. Mashima, H. Shinohara, S. Satoh, Y. Arima, T. Gomi, T. Hirose, I. Ikai, T. Morimoto, T. Inamoto, Y. Yamaoka; Long-duration xenogeneic extracorporeal pig liver perfusion with human blood. Transpl. Int., 9 (Suppl 1): S388-S391, 1996.

Yagi T, Terajima H, Mashima S, Shirakata Y, Shinohara H, Arima Y, Gomi T, Hirose T, Sato S, Nakagami N, Morimoto T, Ozaki N, Ikai I, Inamoto T, Yamaoka Y; Discordant effects of xenogeneic pig liver perfusion on function of sinusoidal endothelial cells and parenchymal cells. Transplant Proc 28: 1402-1403, 1996

H. Terajima, Y. Shirakata, T. Yagi, S. Mashima, H. Shinohara, S. Satoh, Y. Arima, T. Gomi, T. Hirose, R. akahasi, I. Ikai, T. Morimoto, T. Inamoto, M. Yamamoto,Y. Yamaoka; Successful long-term xenoperfusion of the pig liver., Transplantation, 63 (4): 507-512, 1997.

H. Shinohara, A. Tanaka, T. Fujimoto, A. Kanazawa, S. Satoh, E. Hatano, Y. Yamaoka; Prostaglandin E1 resuscitates hepatic organic anion transport independent of its hemodynamic effect after warm ischemia. J Surg Res, 68:56-62, 1997.

T. Yagi, I. Ikai, H. Terajima, S. Satoh, A. Kanazawa, H. Shinohara, T. Uesugi, T. Yoneyama, T. Gomi, R. Takahashi, M. Yamamoto, T. Inamoto, Y. Yamaoka.; The protective effects of prostaglandin E1 on sinusoidal endothelial cells in xenogeneic pig liver perfusion. J Surg Res, 73(1): 28-34, 1997.

S. Satoh, H. Terajima, T. Yagi, A. Kanazawa, H. Shinohara, T. Gomi, T. Uesugi, T. Yonekawa, I. Ikai, R. Takahashi, M. Yamamoto, Y. Yamaoka; Humoral injury in porcine livers perfused with human whole blood. Transplantation, 64(8): 1117-1123, 1997.

M. Kume, Y Yamamoto, R.Okamoto, T. Morimoto, N. Ozaki, M. Yamamoto, Y. Yamaoka. A new aspect of neoadjuvant chemotherapy as a novel strategy to provide the liver with ischemic tolerance; Pharmacological preconditioning of rat livers. Gastroenterology, 112 (4) Suppl: A1310, 1997.

M. Kume, Y. Yamamoto, C-L. Dai, Y. Ishikawa, H. Yamamoto, Y. Sakai, N. Ozaki, Y. Yamaoka. Pharmacological preconditioning by Doxorubicin to induce tolerance of the liver against ischemia-reperfusion injury in rats. Eur Surg Res, 29 Suppl 1: 12, 1997.

S. Kimoto, Y. Yamamoto, M. Kume, H. Yamamoto, K. Yamagami, T. Shimabukuro, N. Ozaki, Y. Yamaoka. The effects of repeated heat-shock pretreatment on warm ischemia-reperfusion injury of the liver in rats. Eur Surg Res, 29 Suppl 1: 45, 1997.

H. Nakayama, Y. Yamamoto, M. Kume, H. Yamamoto, K. Satomura, N. Ozaki, M. Yamamoto, Y. Yamaoka. Biphasic tolerance against ischemia-reperfusion injury after ischemic preconditioning in the rat liver. Eur Surg Res, 29 Suppl 1: 46-47, 1997.

Y. Ishikawa, Y. Yamamoto, M. Kume, K. Yamagami, S. Kimoto, H. Nakayama, N. Ozaki, M. Yamamoto, Y. Yamaoka. Heat-shock preconditioning protects the mitochondrial function in ischemia-reperfusion injury of rat livers. Eur Surg Res, 29 Suppl 1: 45-46, 1997.

C-L Dai, Y. Yamamoto, M. Kume, K. Yamagami, H. Nakayama, N. Ozaki, M. Yamamoto, Y. Yamaoka. Impact of congested portal blood on ischemia-reperfusion injury of the liver assessed by inducible heat-shock protein (HSP) 72 accumulation in the tissue. Eur Surg Res, 29 Suppl 1: 44-45, 1997.

M. Kume, Y. Yamamoto, N. Ozaki, Y. Yamaoka. Pharmacological preconditioning with intravenous administration of Doxorubicin is a hot modality to provide the rat livers with tolerance against warm ischemia-reperfusion injury. J Hepato-Biliary-Pancreatic Surg, 4 Suppl 1: 44, 1997.

S. Kimoto, Y. Yamamoto, M. Kume, N. Ozaki, K. Yamagami, M. Yamamoto, Y. Yamaoka. The effect of HSP72 induction after reperated hyperthermia on subsequent ischemia-reperfusion injury of the rat liver. J Hepato-Biliary-Pancreatic Surg, 4 Suppl 1: 44, 1997.

H. Nakayama, Y. Yamamoto, M. Kume, H. Yamamoto, N. Ozaki, M. Yamamoto, Y. Yamaoka. Biphasic protective effects of ischemic preconditioning against warm ischemia-reperfusion injury on rat liver. J Hepato-Biliary-Pancreatic Surg, 4 Suppl 1: 44, 1997.

Y. Ishikawa, Y. Yamamoto, K. Yamagami, S. Kimoto, H. Nakayama, Y. Yamaoka. Heat shock preconditioning protects mitochondria against ischemia-reperfusion injury in the rat liver. J Hepato-Biliary-Pancreatic Surg, 4 Suppl 1: 43, 1997.

C-L Dai, Y. Yamamoto, M. Kume, N. Ozaki, K. Yamagami, M. Yamamoto, Y. Yamaoka. Portal pooling has a stressful impact on the generation of HSP72 in rat liver after ischemia-reperfusion caused by Pringle's maneuver. J Hepato-Biliary-Pancreatic Surg, 4 Suppl 1: 43, 1997.

H. Nakayama, Y. Yamamoto, M. Kume, H. Yamamoto, N. Ozaki, Y. Yamaoka. Elevated adenosine level in the rat liver is an important factor of ischemic preconditioning to induce tolerance against ischemia-reperfusion injury. Hepatology, 26 (4 - part 2) Suppl: 340A, 1997.

K. Yamagami, Y. Yamamoto, M. Kume, S. Kimoto, N. Ozaki, S. Toyokuni, Y. Yamaoka. Impact of the protection from free radical injury in heat shock preconditioning against ischemia-reperfusion injury in steatotic rat livers. Hepatology, 26 (4 - part 2) Suppl: 339A, 1997.

H. Nishizawa, H. Egawa, Y. Inomata, S. Uemoto, K. Asonuma, T. Kiuchi, Y. Yamaoka, K. Tanaka.Efficiency of pentoxifylline in donor pretreatment in rat liver transplantation. J Surg Res, 72: 170-176,1997.

T. Hirose, H. Terajima, A. Yamauchi, K. Kinoshita, K. Furuke, T. Gomi, Y. Kawai, S. Tsuyuki, Y. Nakamura, I. Ikai, T. Taniguchi, T. Inamoto, Y. Yamaoka. Oxgen dependency of epidermal growth factor receptor binding and DNA synthesis of rat hepatocytes. J Hepatology, 27:1081-1088,1997.

T. Uehara, E. Hatano, K. Honda, M. Yamamoto, Y. Kaneda, Y. Yamaoka Liver-directed gene transfer by hemagglutinating virus of Japan-loposome method. Eur Surg Res, 29 Suppl 1: 52,53, 1997.

E. Hatano, K. Honda, A. Tanaka, M. Yamamoto, B. Chance, Y. Yamaoka Adenovirus-mediated myoglobin gene transfer to the liver in vitro and in vivo. Eur Surg Res, 29 Suppl 1:80,81, 1997.

婦人科学産科学分野 ( Gynecology and Obstetrics )

Nakamura, K, Fujiwara, H, Nakayama, T, Goto, Y, Tachibana,T, Suginami, H, Ueda, M, Maeda, M, and Mori, T, (1996). An aminopeptidase inhibitor, bestatin, enhances gonadotrophin-stimulated ovulation in mice. Hum Reprod., 11, 1952-1957.

Takabatake, K, Fujiwara, H, Goto, Y, Nakayama, T, Higuchi, T, Fujita, J, Maeda, M, and Mori, T, (1997). Splenocytes in early pregnancy promote embryo implantation by regulating endometrial differentiation in mice. Hum. Reprod., 12, 2102-2107.

Nakamura, K, Fujiwara, H, Higuchi, T, Honda, T, Nakayama, T, Kataoka, N, Fujita, K, Ueda, M, Maeda, M, and Mori, T, (1997). Integrin a6 Is Involved in Follicular Growth in Mice. Biochem. Biophys. Res. Commun., 235, 524-528.

心臓血管外科学分野 (Cardiovascular Surgery)

K Nishimura, CH Park, T Akamatsu, T Yamada and T Ban (1996). Development of a magnetically suspended centrifugal pump as a cardiac assist device for long-term application. ASAIO J, 42, 68-71.

H Mizuhara, T Koshiji, K Nishimura, S Nomoto, K Matsuda, N Tsutsui, K Kanda, T Ban (1996). Applicability of the latissimus dorsi muscle as a biological energy source. Heart Replacement - Artificial Heart 5, T Akutsu, H Koyanagi (eds.), Springer-Verlag, Tokyo, 255-257.

CH Park, K Nishimura, M Kitano, K Matsuda, Y Okamoto, T Ban (1996). Analysis of right ventricular function during left heart bypass by afterload alterations both in normal and failing hearts. J Thorac Cardiovasc Surg, 111, 1092-1102.

H Mizuhara, T Oda, T Koshiji, T Ikeda, K Nishimura, S Nomoto, K Matsuda, N Tsutsui, K Kanda, T Ban (1996). A compressive type skeletal muscle pump as a biomecanical energy source. ASAIO J, 42, M637-641.

CH Park, K Nishimura, T Akamatsu, T Tsukiya, K Matsuda, T Ban (1996). A new magnetically suspended centrifugal pump: in vitro and preliminary in vivo assessment. Artif Organs 20, 128-131.

T Ikeda, H Itoh, Y Komatsu, M Hanyu, T Yoshimasa, K Matsuda, K Nakao, T Ban (1996). Natriuretic peptide receptors in human artery and vein and rabbit vein graft. Hypertension, 27[part 2], 833-837.

M Aota, K Matsuda, N Isowa, H Wada, J Yodoi, T Ban (1996). Protection against reperfusion-induced arrhythmias by human thioredoxin. Journal of Cardiovascular Pharmacology 27, 727-732.

J Nishizawa, A Nakai, T Higashi, M Tanabe, S Nomoto, K Matsuda, T Ban, K Nagata (1996). Reperfusion causes significant activation of heart shock transcription factor 1 in ischemic rat heart. Circulation 94, 2185-2192.

築谷朋典、赤松映明、西村和修、朴　昌禧（1996）. 磁気浮上型遠心ポンプにおける流量、圧力差の間接測定とポンプの運転モード. 人工臓器　25、249-254.

西村和修（1996）. 定常流ポンプによる長期循環補助. 日本外科宝函　65、1-2.

T Tsukiya, T Akamatsu, K Nishimura, T Yamada, T Nakazeki (1997). Use of motor current in flow rate measurement for the magnetically suspended centrifugal blood pump. Artif Organs 21, 396-401.

T Yamada, K Nishimura, T Akamatsu, T Tsukiya, CH Park, S Kono, K Matsuda, T Ban. In vivo testing of a magnetically suspended centrifugal pump designed for long-term use. Int J Artif Organs 20, 562-569.

K Nishimura, T Tsukiya, T Akamatsu, S Kono, T Yamada, T Ban (1997). Control of pressure-flow relationship with a magnetically suspended centrifugal pump in chronic animal experiment. ASAIO J 43, M553-556.

S Kono, K Nishimura, T Yamada, T Ohnishi, T Tsukiya, T Akamatsu, T Ban (1997). In-vivo and In-vitro evaluation of a pulsatile mode of a magnetically suspended centrifugal pump (MSCP). ASAIO J 43, M580-584.

T Minoura, H Mizuhara, S Tsutusumi, K Nishimura, T Ban (1997). A computer simulation study of isometric contraction of latissimus dorsi muscle for cardiac assistance. ASAIO J 43, M781-786.

T Yamada, K Nishimura, CH Park, S Kono, S Yuasa, T Tsukiya, T Akamatsu, K Matsuda, T Ban (1997). Chronic animal experiment with magnetically suspended centrifugal pump. Artif Organs 21, 635-638.

築谷朋典、赤松映明、西村和修（1997）. 磁気浮上式遠心血液ポンプの流量測定法. 人工臓器　26、98-102.

筋・骨格系病態学分野 (Orthopaedic and Musculoskeletal Surgery)

Yasuda,T., Shimizu,K., and Nakamura, T. (1996). Effects of dexamethasone on fibronectin synthesis differ depending on the differentiation stages of chondrocytes in cultures. Biomedical Research, 17, 1-8.

Tamaura, J., Kawanabe, K., Kobayashi, M., Nakamura, T., and Kokubo, T. (1996). Mechanical and Biological properties of two types of bioactive bone cements containing

MgO-CaO-SiO2-P2O5-CaF2 glass and glass-ceramic powder. Journal of Biomedical Materials Research, 30, 85-94.

Kitsugi, T., Nakamura, T., Oka, M., Senaha, Y., Goto, T., and Shibuya, T. (1996). Bone-bonding behavior of plasma-sprayed coatings of bioglass, AW-glass ceramic, and tricalcium phosphate on titanium alloy. Journal of Biomedical Materials Research, 30, 261-269.

Nagano, M., Nakamura, T., Kokubo, T., Tanahashi, M., and Ogawa, M. (1996) Differences of bone bonding abiity and degradation behavior in vivo between amorphous calcium phosphate and higly crystalline hydroxyapatite coating. Biomaterials,17, 1771-1777.

Nagano, M., Kitsugi, T., NAkamura, T., Kokubo, T., and Tanahashi, M. (1996). Bonebonding ability of an apatite -coated polymer produced using a biomimetic method: Amechanical and histological study in vivo. Journal of Biomedical Materials Research, 31, 487-494.

Yasuda, T., Shimizu, K., Ishikawa, H., and Nakamura, T. (1996). Aliteration in fibronectin synthesis during rat growth plate chondrocyte differentiation in culture. Biomedical Research , 17, 297-303.

Kitsugi, T., Nakamura, T., Oka, M., Yan, W.Q., Goto, T., Shibuya, T., Kokubo, T.,and Miyaji, S. (1996). Bone bonding behavior of titanium and its alloys when coated with titanium oxide (TiO2) and titanium silicate (Ti5Si3). Journal of Biomedical Materials Research, 32, 149-156.

Takahashi, M., Nakamura, T., Oka, M., and Tamura, M. (1996). Enchancement of bone bonding to bioactive ceramic by basic fibrobalast growth factor. Bioceramics, 9, 107-110.

Yasuda, T., Shimizu, K., Nakagawa, Y., Ishikawa, H., Nishihara, H., Nakamura, T. (1996). Possible invovement of RGD(Arg-Gly-Asp) containing extracellular matrix proteins in rat growth plate chondrocyte differentiation in culture Journal of Bone and Mineral Research 11,1430-1437.

Yan, W.Q., Nakamura, T., Kobayashi, M., Kokubo, T., Nakamura, T. (1996). Bone bonding behavior of titanium implants prepared via chemical treatments. Bioceramics, 9, 305-308.

Nakayama, T., Toguchida, J., Wadayama, B., Kanoe, H., Aizawa, S., Sasaki, M., Nakamura, T. (1996) Fracture healing is a process independant of p53 function. in vivo, 10, 553-558.

Kobayashi, M., Nakamura, T., Tamura, J., Kawanabe, K., Kokubo, T., Kikutani, T. (1996) Bioactive bone cement : comparison of AW-GC filler with hydroxyapatite and β-TCP fillers on biological properties. Bioceramics, 9, 239-242.

Tamura, J., Kitsugi, T., Iida, H., Fujita, H., Nakamura, T., Kokubo, T., Yoshihara, S. (1997) Bone Bonding Ability of Bioactive Bone Cement. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 343, 184-191.

Fujita, H., Nakamura, T., Tamura, J., Kobayashi, M., Katsura, Y., Kokubo, T., Kikutani, T. (1997) Bioactive bone cement : Effect of the amount of glass-ceramic powder on bone-bonding strength. Journal of Biomedical Material Research, 40, 145-152.

Kobayashi, M., Kikutani, T., Kokubo, T., Nakamura T. (1997) Direct bone formation on alumina bead composite. J.Biomed Mater Res., 37 , 554-565.

Kobayashi, M., Nakamura, T., Tamura, J., Kokubo, T., Kikutani, T. (1997 ) Bioactive bone cement: comparison of AW-GC filler with hydroxyapatite andβ-TPC fillers on mechanical and biological properties. J.Biomed.Mater Res., 37, 301-313.

Kobayashi , M., Nakamura, T., Tamura, J., Iida, H., Fujita, H., Kokubo, T., Kikutani, T. (1997) Mechanical and biological properties of bioactive bone cement containing silica glass powder J.of Biomedical Materials Res., 37, 68-80.

Yan, W.Q., Nakamura, T., Kobayashi, M., Kim, H-M., Miyaji, F., Kokubo, T. (1997 ) Bonding of chemically treated titanium implants. J.of Biomedical Materials Res. , 37, 267-275.

Fujita, H., Nakamura ,T., Ido, K., Matsuda, Y., Iida, H. (1997) Bioactive bone cement studied in canine total hip arthroplasty, 2years follow up study. Bioceramics, 10 , 497-500.

Kobayashi,M., Nakamura, T., Kikutani, T., Okada, Y., Ikeda, N., Shinzato, S., Kokubo, T. (1997) Mechanical and biological properties of almina bead composite., Bioceeramics, 10, 313-316.

Kawanabe, K., Okada, Y., Kikutani, T. , Okada, Y., Ikeda, N., Shinzatoo, S., Kokubo, T. (1997) Treatment of osteomyelitis by Antibiotic-soaked porous A-W glass ceramic block., Bioceramics, 10, 87-90.

Akagi, M., Tsuboyama, T., Ikenaga, M., Matsusue, Y., Hiraoka, M., Nakamura, T. (1997) Anti-tumour effects of localized hyperthermia on an experimental bone tumour using an intramedullary nail. INT.J.HYPERTHERMIA, 13 , 387-400.

Ijiri ,S., Nakamura ,T., Fujisawa, Y., Hazama, M., Komatsudani, S. (1997) Ectopic bone induction in porous apatite-wollastonite containing glass ceramic combined with bone morphogenetic protein. J Biomed Mater Res., 35, 421-432.

Matsuda, Y., Nakamura, T., Ido, K., Oka, M., Okumura, H., Matsushita, T. (1997) Femoral component made of Ti-15Mo-5Zr-3Al alloy in total hip arthoplasty. J.of Orthopaedic Science, 2, 166-170.

視覚病態学分野 ( Ophthalmology and Visual Science )

Kashii S,Mandai M, Kikuchi M, Honda Y, Tamura Y, Kaneda Y, Akaike A (1996). Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in the cultured retinal neurons. Brain Res., 711, 93-101.

Mandai M, MittagT. W, Kogishi J, Iwaki M, Hangai M,Yoshimura N (1996). Role of nitric oxide synthase isozymes in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci., 37,826-32.

Kaneda K, Kikuchi M, Kashii S, Honda Y, Maeda T, Kaneko S, Akaike A (1997). Effects of B vitamins on glutamate-induced neurotoxicity in retinal cultures. Eur J Pharmacol., 322, 259-264.

Kikuchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A (1997). Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neutotoxicity in retinal culture. Invest Ophthalmol Vis Sci., 38, 848-54.

Morizane C, Adachi K, Furutani I, Fujita Y, Akaike A, Kashii S, Honda Y (1997). Nw-Nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo. Eur J Pharmacol., 328, 45-49.

Saji H, Kinoshita T, Kubota M, Kaneda K, Akaike A, Kikuchi M, Kashii S, Honda Y, Iida Y, Magata Y, Yokoyama A (1997). Brain permeable zinc complex with neuroprotective action. S. T. P. Pharma Sciences., 7, 92-97.

Suzuma K, Mandai M, Kogishi J, Tojo S. J,Honda Y, Yoshimura N (1997). Role of P-selectin in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci., 38, 1610-18.

腫瘍外科学分野 (Surgery and Surgical Basic Science)

Yamasaki S., Okino T., Ichinose Y., Moriguchi Y., Li L., Sugie T., Kan N., Imamura M., Mukherji B.(1996) "Availability of autologous antigen presenting cells for peptide vaccine therapy" in Japanese. Biotherapy 10(5):765-767

Okino T., Yamasaki S.,Kanaoka S., Li L., Imamura M. (1996) "Cancer immunotherapy using antigen presenting cells" in Japanese. Geka 58(13):1809-1813

Moriguchi Y., Kan N., Okino T., Harada T., Yamasaki S., Ichinose Y., Li L., Sugie T., Imamura M.(1996) "A new model of active specific immunotherapy using interleukin-1 and sonicated tumor supernatant in murine tumor system" J. Surg. Oncol. 62:78-85

Fujita S, Arii S, Monden K, Ishiguro S, Kitao T, Nakamura T, Imamura M. (1996) The preventive effects of OK-432 on endotoxin-induced liver injury: Liver protection by the modulation of hepatic macrophages function. Surgery Today 26:29-35

Funaki N, Arii S, Monden K, Tanaka J, Imamura M. (1996) HLA-DR antigen and interleukin-2 receptor expression on primary-cultured hepatic macrophages in relation to liver cirrhosis and hepatitis virus infection. Life Science 58:552-559

Nakamura T, Arii S, Monden K, Sasaoki T, Adachi Y, Ishiguro S, Fujita S, Mizumoto M, Imamura M. (1996) Amelioration by Kupffer cell blockade in hepatic damage induced by cold preservation with subsequent plasma-supplemented perfusion. J Surg Res 62:207-215

Doi R, Wada M, Hosotani R, Lee J-U, Koshiba T, Fujimoto K, Mori C, Nakamura N, Shiota K and Imamura M. Role of apoptosis in duct obstruction-induced pancratic involution in rats. (1997) Pancreas 14:39-46

Wada M, Doi R, Hosotani R, Lee J-U, Fujimoto K, Koshiba T, Miyamoto Y, Fukuoka S, Imamura M. (1997) Expression of Bcl-2 and PCNA in duct cells after pancreatic duct ligation in rats. Pancreas 15:176-182

Fujimoto K, Hosotani R, Wada M, Lee J-U, Koshiba T, Miyamoto Y, Doi R and Imamura M. (1997) Ischemia-reperfusion injury on the pancreas in rats: Identification of acinar cell apoptosis. J Surg Res. 71:127-136

Fujimoto K, Hosotani R, Doi R, Wada M, Lee J-U, Koshiba T, Miyamoto Y and Imamura M. (1997) Role of neutrophils in cerulein-induced pancreatitis in rats: Possible involvement of apoptosis. Digestion. 58:421-430

Okino T., Yamasaki S., Kanaoka S. "Specific tumor immunotherapy using antigen-presenting cells and tumor-antigen-derived peptides" in Japanese. (1997) Biother. Today 4(2):86-90

Moriguchi Y, Kan N, Okino T, Teramura Y, Yamasaki S, Ichinose Y, Li L, Sugie T, Kuribayashi K, Watanabe Y, Imamura M. (1997) "The effectiveness of active specific immunotherapy using interferon-g-gene-transduced tumor cells in a murine tumor model" Jpn. J. Surg. 27:571-573

Niwano M, Arii S, Monden K, Ishiguro S, Nakamura T, Mizumoto M, Takeda Y, Fujioka M, Imamura M.(1997) Amelioration of sinusoidal endothelial cell damage by Kupffer cell blockade during cold perfusion of rat liver. J Surg Res. 72:36-48

Mizumoto M, Arii S, Furutani M, Nakamura T, Ishiguro S, Monden K, Fujita S, Imamura M. (1997) NO as an indicator of portal hemodynamics and the role of iNOS in increased NO perfusion in CCl4-inducued liver cirrhosis. J Surg Res. 70:124-133

附属動物実験施設 (Institute of Laboratory Animals)

Yokoi, N., Kitada, K., Kuramoto, T., Maihara, T., Higaki, J., Miki, T., Ogihara, T. and Serikawa, T. (1996). Mapping of 20 polymorphic DNA markers in the rat by somatic hybrid and linkage analysis. Mamm. Genome, 7, 71-73.

Takami, S., Higaki, J., Miki, T., Katsuya, T., Nakata, Y., Rakugi, H., Serikawa, T., Ogihara,T. ( 1996). Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains. Hypertens. Res., 19, 51-56.

Momiyama, T., Ishihara, K., Kimura, K., Todo, N., Fujita, Y., Serikawa, T., Sasa,M. (1996). Long-term antiepileptic effects of chronic intake of CNK-602A, a thyrotropin-releasing hormone analogue, on spontaneously epileptic rats. Epilepsia 37, 328-331.

Toyota, M., Canzian, F., Ushijima, T., Hosoya, Y., Kuramoto, T., Serikawa, T., Imai, K., Sugimura, T., Nagao. M. (1996). A rat genetic map constructed by representational difference analysis markers with suitability for large-scale typing. Proc. Natl. Acad. Sci. USA, 93, 3914-3919.

Li, X. M., Salido, E. C., Gong, Y., Kitada, K., Serikawa, T., Yen, P. H., Shapiro, L. J. (1996). Cloning of the rat steroid sulfatase gene (Sts), a non-pseudoautosomal x-linked gene that undergoes X inactivation. Mamm. Genome, 7, 420-424.

Amano, S., Ihara, N., Uemura, S., Yokoyama, M., Ikeda, M., Serikawa, T., Sasahara, M., Kataoka, H., Hayase, Y., Hazama, F. (1996). Development of a novel rat mutant with spontaneously limbic-like seizures. Am. J. Pathol., 149, 329-336.

Kondo, Y., Ohno, K., Oda, S., and Serikawa. T. (1996). Genetic profile of three inbred strains derived from wild rats (Rattus norvegicus ) trapped in Japan. Exp. Anim., 45 , 405-409.

Ohno, Y., Matsuo, K., Suzuki, H., Tanase, H., Serikawa, T., Takano,T., Saruta,T. ( 1996). Genetic linkage of the sarco(endo)plasmic reticulum Ca2+-dependent ATPase II gene to intracellular Ca2+ concentration in the spontaneously hypertensive rat. Biochem. Biophys. Res. Comm., 227, 789-793.

Kuramoto, T., Sotelo, C., Yokoi, N., Serikawa, T., Sintes, E.G., Martorell, J.C., and Guenet, J.-L. (1996) A rat mutation producing demyelination (dmy ) maps to chromosome 17. Mamm. Genome, 7, 890-894.

Fujita, M., Takahashi, R., Kitada, K., Watanabe, R., Kitazawa, S., Ashoori, F., Liang, P., Saya, H., Serikawa, T. and Maeda, S. (1997). Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cell. Cancer Lett., 112, 47-55.

Nabika, T., Ito, T., Kitada, K., Serikawa, T., Mashimo, T., Soubrier, F., Julier, C., Ohno, Y., Saruta, T., Tanase, H., Masuda, J.,Yamaori, Y., Nara,Y. ( 1997). Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1 Mamm. Genome, 8, 215-217.

Serikawa, T., van Zutphen, L.F.M. (1997). Rat Chromosome 3, Rat Genome 3, 46-54.

Murakami, M., Nakajima, K., Yamzaki, K., Muraguchi, T., Serikawa, T., Honjo,T. (1997). Effects of breeding environment on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. J. Exp. Med., 185 , 791-794.

Ookohchi, T., Ito, H., Serikawa, T., Sato, K. (1997). Detection of apoptosis in the brain of the zitter rat with genetic spongiform encephalopathy. Biochem. Mol. Biol. Inter., 41, 279-284.

Kondo, Y., Sato, K., Kitada, K. and Serikawa,T. (1997). Application of mouse microsatellite markers to rat genome mapping. Transpl. Proc., 27, 1766-1767.

Hamada, S., Nishikawa, T., Yokoi, N. and Serikawa,T. (1997). TM Rats: A model for platalet strage pool deficiency. Exp. Anim. 46,235-239.

Koike, R., Watanabe, T., Satoh, H., Hee, C. S., Kitada, K., Kuramoto, T., Serikawa, T., Miyawaki, S., Miyasaka,M. (1997). Analysis of expression of lymphocyte homing-related adhesion molecules in ALY mice deficient in lymph nodes and Peyerﾕs patches. Cell. Immunol., 180, 62-69.

Yokoi, N., Kanazawa, M., Kitada, K., Tanaka, A., Kanazawa, Y., Suda, S., Ito, H., Serikawa, T., Komeda, K. (1997). A non-MHC locus essential for autoimmune type 1 diabetes in the Komeda diabetes-prone rat. J. Clin. Invest.,100,2015-2021.

附属先天異常標本解析センター (Congenitary Anomaly Research Ceneter)

Sugisaki, N., Hirata, T., Naruse, I., Kawakami, A., Kitsukawa, T. and Fujisawa, H. (1996). Positional cues that are strictly localized in the telencephalon induce preferential growth of mitral cell axons. J. Neurobiology, 29, 127-137.

Ueda, S., Aikawa, M., Kawata, M., Naruse, I., Whitaker-Azmitia, P.M. and Azmitia, E.C. (1996). Neuro-glial neurotrophic interaction in the S-100b retarded mutant mouse (Polydactyly Nagoya). III. Transplantation study. Brain Res., 738: 15-23.

Naruse, I., Keino, H. and Taniguchi, M. (1996) Fetal laser surgery exo utero in mice. Cong. Anom. 36, 107-113.

成瀬一郎　(1996)　実験発生学における胎内治療。小児耳鼻咽喉科研究会誌、17, 2, 14-17.

成瀬一郎　慶野裕美 (1996) 形態形成とプログラム細胞死。アポトーシスの分子機構と病態、pp.36-42、内海耕造、井上正康編、メディカルトリビューンブックス、アクセル・シュプリンガー出版、東京。

成瀬一郎　(1996) アポトーシス　ー形態形成における役割ー。組織細胞化学 1996、pp. 199-202、日本組織細胞化学会編、学際企画、東京。

Naruse, I., Keino, H. and Taniguchi, M. (1997) Surgical manipulation of mammalian embryos in vitro. Int. J. Dev. Biol., 41, 2, 195-198.

Tanaka, Y., Naruse, I., Maekawa, T., Masuya, H., Shiroishi, T. and Ishii, S. (1997). Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome. ProNAS, 94, 19, 10215-10220.

Taniguchi, M., Yuasa, S., Fujisawa, H., Naruse, I., Saga, S., Mishina, M. and Yagi, T. (1997) Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron, 19, 3, 519-530.