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京都大学動物実験委員会
医・動物実験委員会
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関西実験動物研究会

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研究室(Research)


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 京都大学大学院医学研究科
 附属動物実験施設
京都大学 動物実験施設外観
    Institute of Laboratory Animals
    Graduate School of Medicine, Kyoto University
    

京都大学医学部附属動物実験施設報 第4号

動物実験施設利用者研究業績

(1998年〜1999年)

1)生理系専攻 (Physiology)

生体情報科学講座 (Biological Sciences)

  生体情報科学分野 (Biological Sciences)

生体制御医学講座 (Bioregulation)

  循環生理学分野 (Pharmacology)

2)病理系専攻 (Pathology)

基礎病態学講座 (Basic Pathology)

  病態生物医学分野 (Pathology and Biology of Diseases)

感染・免疫学講座 (Infectious Diseases and Immunology)

  免疫細胞生物学分野 (Immunology and Cell Biology)

3)分子医学系専攻 (Molecular Medicine)

分子生体統御学講座 (Moleculer Biology)

  分子生物学分野 (Medical Chemistry)

  分子細胞情報学分野 (Cell Biology)

  分子腫瘍学分野 (Molecular Oncology)

遺伝医学講座 (Molecular Genetics)

  分子遺伝学分野 (Molecular Genetics)

4)脳統御医科学系専攻 (Neuroscience)

高次脳科学講座 (Basic Neuroscience)

  神経・細胞薬理学分野 (Cell Pharmacology)

  認知行動脳科学分野 (Integrative Brain Science)

脳病態生理学講座 (Clinical Neuroscience)

  脳神経外科学分野 (Neurosurgery)

5) 内科系専攻 (Internal Medicine)

臨床病態医科学講座 (Medicine and Clinical Science)

  病態代謝栄養学分野 (Metabolism and Clinical Nutrition)

  臨床病態医科学分野 (Medicine and Clinical Science)

臨床器官病態学講座 (Clinical Sciences for Pathological Organs)

  循環病態学分野 (Cardiovascular Medicine)

  消化器病態学分野 (Gastroenterology and Hepatology)

臨床生体統御医学講座 (Clinical Bioregulation)

  加齢医学分野 (Geriatric Medicine)

放射線医学講座 (Radiology and Nuclear Medicine)

  腫瘍放射線科学分野 (Therapeutic Radiology and Oncology)

  核医学・画像診断学分野 (Nuclear Medicine and Diagnostic Imaging)

6)外科系専攻 (Surgery)

器官外科学講座 (Surgery for Visceral Organs)

  消化器外科学分野 (Gastroenterological Surgery)

  婦人科学産科学分野 (Gynecology and Obstetrics)

  心臓血管外科学分野 (Cardiovascular Surgery)

感覚運動系病態学講座 (Surgery for Sensory and Motor Systems)

  筋・骨格系病態学分野 (Orthopaedic and Musculoskeletal Surgery)

  視覚病態学分野 (Ophthalmology and Visual Science)

  口腔機能病態学分野 (Oral and Maxillofacial Surgery)

  形成外科学分野 (Plastic and Reconstructive Surgery)

7)分子医学系専攻 (Molecular Medicine)

遺伝医学講座 (Medical Genetics)

  腫瘍外科学分野 (Surgery and Surgical Basic Science)

8) 附属動物実験施設 (Institute of Laboratory Animals)

 

 

 

生体情報科学分野 (Biological Sciences)

Watanabe, D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R., Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki, M., Kobayashi, K., Nagatsu, T., Kreitman, R. J., Pastan, I., and Nakanishi, S. (1998). Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell 95, 17-27.

Masugi, M., Yokoi, M., Shigemoto, R., Muguruma, K., Watanabe, Y., Sansig, G., van der Putten, H., and Nakanishi, S. (1999). Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci 19, 955-63.

Tagawa, Y., Sawai, H., Ueda, Y., Tauchi, M., and Nakanishi, S. (1999). Immunohistological studies of metabotropic glutamate receptor subtype 6- deficient mice show no abnormality of retinal cell organization and ganglion cell maturation. J Neurosci 19, 2568-79.

 

循環生理学分野 (Pharmacology)

Kikuta, K., Sawamura, T., Miwa, S., Hashimoto, N., and Masaki, T. (1998). High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine. Circ Res, 83, 1088-1096.

Zhang, X.-F., Komuro, T., Miwa, S., Minowa, T., Iwamuro, Y., Okamoto, Y., Ninomiya, H., Sawamura, T., and Masaki, T. (1998). Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide. Eur J Pharmacol, 352, 237-245.

Iwamuro, Y., Miwa, S., Minowa, T., Enoki, T., Zhang, X.-F., Ishikawa, M., Hashimoto, N., and Masaki, T. (1998). Activation of two types of Ca2+-permeable nonselective cation channel by endothelin-1 in A7r5 cells. Br J Pharmacol, 124, 1541-1549.

Hasegawa, H., Hiki, K., Sawamura, T., Aoyama, T., Okamoto, Y., Miwa, S., Shimohama, S., Kimura, J., and Masaki, T. (1998). Purification of a novel endothelin-converting enzyme specific for big endothelin-3. FEBS Lett, 428, 304-308.

Okamoto, Y., Ninomiya, H., Tanioka, M., Sakamoto, A., Miwa, S., and Masaki, T. (1998). Cysteine residues in the carboxy1 terminal domain of endothelin-B receptor are required for coupling with G-proteins. J Cardiovasc Pharmacol, 31, S230-S232.

Lee, K., Morita, H., Iwamuro, Y., Zhang, X.-F., Okamoto, Y., Nakagawa, T., Hasegawa, H., Furutani, H., Miwa, S., and Masaki, T. (1999). Pharmacological characterization of receptor-mediated Ca2+ entry in endothelin-1-induced catecholamine release from cultured bovine adrenal chromaffin cells. Naunyn-Schmiedeberg's Arch Pharmacol, 360, 616-622.

Zhang, X.-F., Iwamuro, Y., Okazawa, M., Lee, K., Minowa, T., Komuro, T., Okamoto, Y., Hasegawa, H., Furutani, H., Miwa, S., and Masaki, T. (1999). Pharmacological characterization of Ca2+ entry channels in endothelin-1-induced contraction in rat aorta using LOE 908 and SK&F 96365. Br J Pharmacol, 127, 1388-1398.

Iwamuro, Y., Miwa, S., Zhang, X.-F., Minowa, T., Enoki, T., Okamoto, Y., Hasegawa, H., Furutani, H., Okazawa, M., Ishikawa, M., Hashimoto, N., and Masaki, T. (1999). Activation of three types of voltage-independent Ca2+ channel in A7r5 cells by endothelin-1 as revealed by a novel Ca2+ channel blocker LOE 908. Br J Pharmacol, 126, 1107-1114.

 

病態生物医学分野 (Pathology and Biology of Diseases)

Higashi S, Murai T, Mori S, Kamoto T, Yoshitomi M, Arakawa Y, Makino S, Fukushima S, Yoshida O, Hiai H. (1998). Host genes affecting survival period of chemically induced bladder cancer in mice. J. Cancer Res. Clin. Oncol., 124, 670-6.

Hiai H, Kato S, Horiuchi Y, Shimada R, Tsuruyama T, Watanabe T, Matsuzawa A. (1998). Mapping of Nakano cataract gene nct on mouse chromosome 16. Genomics, 50, 119-20.

Tanuma J, Shisa H, Hiai H, Higashi S, Yamada Y, Kamoto T, Hirayama Y, Matsuuchi H, Kitano M. (1998). Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Cancer Res., 58, 1660-4.

Um SH, Suzuki S, Toyokuni S, Kim BM, Tanaka T, Hiai H and Nishimura Y. (1998). Involvement of nitric oxide in survival of random pattern skin flap. Plast. Reconstr. Surg., 101, 785-792.

Tanaka T, Nishiyama Y, Okada K, Satoh K, Fukuda A, Uchida K, Osawa T, Hiai H and Toyokuni S. (1998). Overexpression of glutathione S-transferase Yp isozyme and concomitant downregulation of Ya isozyme in renal cell carcinoma of rats induced by ferric nitrilotriacetate. Carcinogenesis, 19, 897-903.

Toyokuni S. Oxidative stress and cancer: the role of redox regulation. (1998). Biotherapy 11, 147-154 (review).

Yamagami K, Yamamoto Y, Kume M, Kimoto S, Yamamoto H, Ozaki N, Yamamoto M, Shimahara Y, Toyokuni S and Yamaoka Y. (1998) Heat shock preconditioning ameliorates liver injury following normothermic ischemia-reperfusion in steatotic rat livers. J. Surg. Res., 79, 47-53.

Toyokuni S, Okada K, Kondo S, Nishioka H, Tanaka T, Nishiyama Y, Hino O and Hiai H. (1998). Development of high-grade renal cell carcinomas in rats independent of somatic mutations in the Tsc2 and VHL tumor suppressor genes. Jpn. J. Cancer Res. 89: 814-820.

Minamiyama Y, Takemura S, Toyokuni S, Tanimoto Y, Sato EF and Inoue M. (1998). A processed grain food inhibits hepatic injury in endotoxemic rats. J. Nutr. Sci. Vitaminol. 44, 547 559.

Lu LM, Hiai H. (1999). Mixed phenotype lymphomas in thymectomized (SL/KhxAKR/Ms)F1 mice. Jpn. J. Cancer Res.,90, 1218-23.

Hiai H, Yamada Y, Abujiang P, Lu L, Kamoto T, Tsuruyama T. (1999). Genetic and epigenetic susceptibility to endogenous retrovirus-induced lymphomas in SL mice. Prog Exp Tumor Res.,35, 64-77.

Lu LM, Shimada R, Higashi S, Zeng Z, Hiai H. (1999). Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice. Cancer Res., 59, 2593-5.

Lu LM, Shisa H, Tanuma J, Hiai H. (1999). Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis. Br. J. Cancer, 80, 855-61.

Toyokuni S. (1999). Reactive oxygen species-induced molecular damage and its application in pathology. Pathol. Int. 49, 91-102 (review).

Um SH, Suzuki S, Toyokuni S, Uchida K, Hiai H and Nishimura Y. (1999). Formation of 4-hydroxy-2-nonenal (HNE)-modified proteins and 3-nitro-L-tyrosine in rat island skin flaps during and following ischemia. Ann. Plast. Surg., 42, 293-298.

Tanaka T, Iwasa Y, Kondo S, Hiai H and Toyokuni S. (1999). High incidence of allelic loss on chromosome 5 and inactivation of p15 INK4B and p16 INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene, 18, 3793-3797.

Toyokuni S, Iwasa Y, Kondo S, Tanaka T, Ochi H and Hiai H. Intranuclear distribution of 8-hydroxy-2'-deoxyguanosine: an immunocytochemical study. (1999). J. Histochem. Cytochem. 47, 833-835.

Ihara Y, Toyokuni S, Uchida K, Okada H, Tanaka T, Ikeda H, Hiai H, Seino Y and Yamada Y. (1999). Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes, 48, 927-932.

Toyokuni S and Sagripanti J-L. Iron chelators modulate the production of DNA strand breaks and 8-hydroxy-2'-deoxyguanosine. (1999). Free Radic. Res., 31, 123-128.

Okada K, Wangpoengtrakul C, Osawa T, Toyokuni S, Tanaka K and Uchida K. (1999). 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress in vivo: identification of proteasome as a target molecule. J. Biol. Chem. 274, 23787-23793.

 

免疫細胞生物学分野 ( Immunology and Cell Biology )

Nishimura, H., Minato, N., Nakano, T., and Honjo, T. (1998). Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol, 10, 1563-1572.

Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L., and Rouault, T. A. (1998). Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proc Natl Acad Sci U S A, 95, 4924-4928.

Yamaoka, J., Nakamura, E., Takeda, Y., Imamura, S., and Minato, N. (1998). Mutational analysis of superantigen activity responsible for the induction of skin erythema by streptococcal pyrogenic exotoxin C. Infect Immun, 66, 5020-5026.

Tomita, K., Hattori, M., Nakamura, E., Nakanishi, S., Minato, N., and Kageyama, R. (1999). The bHLH gene Hes1 is essential for expansion of early T cell precursors. Genes Dev, 13, 1203-1210.

Nakamura, E., Sato, M., Yang, H., Miyagawa, F., Harasaki, M., Tomita, K., Matsuoka, S., Noma, A., Iwai, K., and Minato, N. (1999). 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem, 274, 3009-3016.

Gonen, H., Bercovich, B., Orian, A., Carrano, A., Takizawa, C., Yamanaka, K., Pagano, M., Iwai, K., and Ciechanover, A. (1999). Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkBa. J Biol Chem, 274, 14823-30.

Tsukamoto, N., Hattori, M., Yang, H., Bos, J. L., and Minato, N. (1999). Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem, 274, 18463-18469.

Nishimura, H., Nose, M., Hiai, H., Minato, N., and Honjo, T. (1999). Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity, 11, 141-151.

Yokoi, A., Kina, T., and Minato, N. (1999). Selective expression and function of granzyme D in lymphohematopoietic stromal cells. Biochem Biophys Res Commun, 264, 768-73.

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., and Pause, A. (1999). Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A, 96, 12436-12441.

Yamanaka, K., Minato, N., and Iwai, K. (1999). Stabilization of iron regulatory protein 2, IRP2, by aluminum. FEBS Lett, 462, 216-220.

 

分子生物学分野 (Medical Chemistry)

Watanabe, N., Nomura, T., Takai, T., Chiba, T., Honjo, T. and Tsubata, T. (1998). Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells. Scand. J. Immunol., 47, 541-547.

Nisitani, S., Sakiyama, T. and Honjo, T. (1998). Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte Ig transgenic mice. Int. Immunol., 10, 1039-1047.

Nishimura, H., Minato, N., Nakano, T. and Honjo, T. (1998). Immunological studies on PD-1-deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol., 10, 1563-1572.

Adachi, S., Yoshida, H., Honda, K., Maki, K., Saijo, K., Ikuta, K., Saito, T., and Nishikawa, S. (1998). Essential role of IL-7 receptor a in the formation of Peyerユs patch anlage. Int. Immunol., 10, 1-6. Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T. and Honjo, T. (1999). Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kb-inducing kinase. Nat. Genet., 22, 74-77.

Nisitani, S. and Honjo, T. (1999). Breakage of B cell tolerance and autoantibody production in anti- erythrocyte transgenic mice. Intern. Rev. Immunol., 18, 259-270.

Sakiyama, T., Nshitani, S., Ikuta, K., Takatsu, K.and Honjo, T. (1999). Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice. Int. Immunol. 11, 995-1000.

Watanabe, N., Nisitani, S., Ikuta, K., Chiba, T. and Honjo, T. (1999). Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of auto-reactive B-1 cell compartment. J. Exp. Med., 190, 461-469.

Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T. (1999). Development of lups-like autoimmune disease by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity,11, 141-151.

Ye, S.-K., Maki, K., Kitamura, T., Akashi, K., Domen, J., Weissman, I. L., Honjo, T. and Ikuta K. (1999). Induction of Germline Transcription in the TCRg Locus by Stat5: Implications for Accessibility Control by the IL-7 Receptor. Immunity, 11, 213-223.

Minoguchi, S., Ikeda, T., Itohara, S., Kaneko, T. Okaichi, H. and Honjo, T. (1999). Studies on Cell-type Specific Expression of RBP-L, a RBP-J Family Member by Replacement Insertion of b-Galactosidase. J. Biochem., 126, 738-747.

Ochi, H., Takeshita, H., Suda, T., Nisitani, S., Watanabe, T. and Honjo, T. (1999). Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings. Immunology, 98, 595-603.

Yoshida, H., Honda, K., Shinkura, R., Adachi, S., Nishikawa, S., Maki, K., Ikuta, K., and Nishikawa, S. (1999). IL-7 receptor a+ CD3- cells in the embryonic intestine induces the organizing center of Peyer's patches. Int. Immunol., 11, 643-655.

 

分子細胞情報学分野 (Cell Biology)

Yonemura,S., Hirao,M., Doi,Y., Tsukita,Sa., and Tsukita,Sh. (1998). ERM proteins bind to a specific group of integral membrane proteins containing a positively-charged amino acid cluster in their juxta-membrane cytoplasmic domain J.Cell Biol. 140, 885-895

Matsui,T., Maeda,M., Yonemura,S., Amano,M., Kaibuchi,K., Tsukita,Sa., and Tsukita,Sh.(1998) Rho-kinase phosphorylates carboxy-terminal threonines of ERM proteins and regulates their head-to-tail associationJ.Cell Biol. 140,647-657.

Morita,K., Itoh,M., Saitou,M., Ando-Akatsuka,Y., Furuse,M., Yoneda,K., Imamura,S., and Tsukita,Sh.(1998) Subcellular distribution of tight junction-associated proteins, occludin, ZO-1 and ZO-2, in rodent skin and its developmental changes J.Inv.Dermatol. 110, 862-866.

Doi, Y., Kurita,M., Matsumoto,M., Kondo,T., Noda,T., Tsukita,Sa., Tsukita,Sh. and Seya,T. (1998) Moesin is not a receptor for measles virus entry into mouse embryonic stem cells. J.Virol. 72, 1586-1592

Sako,Y., Nagafuchi,A., Tsukita,Sh., Takeichi,M. and Kusumi,A.(1998) Cytoplasmic regulation of the movement of E-cadherin on the free cell surface as studied by optical tweezers and single particle tracking: corralling and tethering by the membrane skeleton J.Cell Biol. 140, 1227-1240

Saitou,M., Fujimoto,K., Doi,Y.,Itoh,M., Fujimoto,T., Furuse,M., Takano,H.,(1998) Noda,T. and Tsukita,Sh. Occludin-deficient embryonic stem cells can diferentiate into polarized epithelial cells bearing tightj unctions J.Cell Biol. 141, 397-408.

Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K., and Tsukita,Sh.(1998) Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin J.Cell Biol. 141, 1539-1550.

Oda,H., Tsukita,Sh., and Takeichi,M. (1998) Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastration. Dev. Biol. 203, 435-450.

Moroi,S., Saitou,M., Fujimoto,K., Sakakibara,A., Furuse,M., Yoshida,O., and Tsukita,Sh. (1998) Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. Am.J.Physiol. 274,C1708-C1717.

Furuse,M., Sasaki,H., Fujimoto,K., and Tsukita,Sh. (1998) A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts J.Cell Biol. 143, 391-401.

Tsukita,Sh., and Furuse,M. (1998) Overcoming barriers in the study of tight junction functions: from occludin to claudin Genes Cells.3,569-573.

Chishti,A.H., Kim,A.C.------, Tsukita,Sh., Tsukita,Sa. et al. (1998) The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. TIBS 23, 281-282.

Doi,Y., Itoh,M., Yonemura,S., Ishihara,S., Takano,H., Noda,T., Tsukita,Sh., and Tsukita,Sa. (1999) Moesin gene knockout: Normal development of mice and unimpaired cell adhesion/cell motiltiy/actin-based cytoskeleton without compensatory up-regulation of ezrin and radixin J.Biol.Chem. 274, 2315-2321.

Shiina,N. and Tsukita,Sh. (1999) Mutations at phosphorylation sites of Xenopus microtubule-associated protein 4 affect its microtubule-binding ability and chromosome movement during mitosis Mol.Biol.Cell. 10, 597-608.

Morita,K., Furuse,M., Fujimoto,K., and Tsukita,Sh.(1999) Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc.Natl.Acad.Sci.USA 96, 511-516.

Itoh,M., Morita,K. and Tsukita,Sh. (1999) Characterization of ZO-2 as a MAGUK family member associated with tight and adherens junctions with a binding affinity to occludin and alpha catenin J.Biol.Chem. 274, 5981-5986.

Ando-Akatsuka,Y., Yonemura,S., Itoh,M., Furuse,M., and Tsukita,Sh. (1999) Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity J.Cell Physiol.179, 115-125.

Oda,H. and Tsukita,Sh. (1999) Dynamic features of adherens junctions during Drosophila embryonic epithelial morphogenesis revealed by a Dalpha-cantein-GFP fuion protein Dev.Genes.Evol. 209, 218-225.

Yonemura,S., Tsukita,Sa., and Tsukita,Sh. (1999) Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins J.Cell Biol. 145, 1497-1506.

Morita,K., Sasaki,H., Fujimoto,K., Furuse,M., and Tsukita,Sh. (1999) Claudin-11/OSP-based tight junctions in myelinated sheaths of oligodendrocytes and in Sertoli cells in testis. J.Cell Biol. 145, 579-588.

Hayashi,K., Yonemura,S., Matsui,T., Tsukita,Sa. and Tsukita,Sh. (1999) Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues: Application of a novel fixation protocol using trichloroacetic acids (TCA) as a fixative. J.Cell Sci. 112, 1149-1158.

Imamura,Y., Itoh,M., Maeno,Y., Tsukita,Sh. and Nagafuchi,A. (1999) Functional domains of alpha catenin required for the strong-state of cadherin-based cell adhesion. J.Cell Biol. 144, 1311-1322. Verkhusha,V.V., Tsukita, Sh., Oda, H. (1999) Actin dynamics in lamellipodia of migrating border cells in the Drosophila overy revealed by a GFP-actin fusion protein. FEBS Let. 445, 395-401.

Tsukita,Sh. and Furuse,M. (1999) Occludin and claudins in tight junction strands: Leading or supporting palyers ? Trends in Cell Biol. 9, 268-273.

Maeda,M., Matsui,T., Imamura,M., Tsukita,Sh. and Tsukita,Sa. (1999) Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison with ezrin/radixin/moesin proteinsOncogene18, 4788-4797.

Tsukita,Sh., Furuse,M., and Itoh,M. (1999) Structural and signaling molecules come together at tight junctions. Curr.Opin.Cell Biol. 11, 628-633.

Tsukita,Sh., Furuse,M., and Itoh,M. The tight junction Cell Adhesion M.Beckerle, ed. (1999)

Hiiragi,T., Sasaki,H., Nagafuchi,A., Sabe,H., Shen,S.C., Matsu ki,M., Yamanishi,K., and Tsukita,Sh. (1999) Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells J.Biol.Chem. 274, 34148-34154.

Furuse,M., Sasaki,H., and Tsukita,Sh. (1999) Manner of interaction of heterogenous claudin species within and between tight junction strands. J.Cell Biol. 147, 891-903.

Itoh,M., Furuse,M., Morita,K., Kubota,K., and Tsukita,Sh. (1999) Molecular basis for the recruitment of three MAGUKs, ZO-1, ZO-2 and ZO-3, to tight junctions: Direct binding of their first PDZ domains to the COOH-termini of claudins. J.Cell Biol. 147, 1351-1363.

Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A., and Tsukita,Sh. (1999) Ca++-independent cell adhesion activity of claudins, integral membrane proteins of tight junctions. Curr Biol. 9, 1035-1038.(1999)

Matsui,T., Yonemura,S., Tsukita,Sh. and Tsukita,Sa. (1999) Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases . Curr. Biol. 9, 1259-1262.

Sonoda,N., Furuse,M., Sasaki,H., Yonemura,S., Katahira,J., Horiguchi,Y., and Tsukita,Sh. (1999) Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J.Cell Biol. 147, 195-204.

Maeno,Y., Moroi,S., Nagashima,H., Noda,T., Shiozaki,H., Monden,M., Tsukita,Sh. and Nagafuchi,A. (1999) Alpha-catenin-deficient F9 cells differentiate into signet ring cells. Am.J.Pathol. 154, 1323-1328.

Morita,K., Sasaki,H., Furuse,M. and Tsukita,Sh. (1999) Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J.Cell Biol. 147, 185-194.

Oda,H., and Tsukita,Sh. (1999) Nonchordate classic cadherins have a structurally and functionally unique domain that is absent from chordate classic cadherins Dev.Biol. 216, 406-422.

Kubo,A., Sasaki,H., Yuba-Kubo,A., Tsukita,Sh., and Shiina,N.(1999) Centriolar satellites: Molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J.Cell Biol. 147, 969-980.

 

分子腫瘍学分野 (Molecular Oncology)

C. Takahashi, Z. Sheng, T. P. Horan, H. Kitayama, M. Maki, K. Hitomi, Y. Kitamura, S. Takai, R. M. Sasahara, A. Horimoto, Y. Ikawa, B. J. Ratzkin, T. Arakawa and M. Noda: Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by a novel membrane-anchored glycoprotein RECK. Proc. Natl. Acad. Sci. USA 95, 13221-13226 (1998)

M. Kojima, M. Asahi, H. Kikuchi, N. Hashimoto, M. Noda and M. Hoshimaru: Expression of Nedd2/ICH-1 (caspase-2) in the developing rat retina. Neurosci. Res. 31, 211-217 (1998)

H. Akiyama, Y. Hiraki, M. Noda, C. Shigeno, H. Ito and T. Nakamura: Molecular cloning and biological activity of a novel H-ras suppressor gene predominantly expressed in skeletal muscle, heart, brain and bone marrow by differential display using clonal mouse EC cells, ATDC5. J. Biol. Chem. 274, 32192-32197 (1999)

 

分子遺伝学分野 (Molecular Genetics)

Yokota, Y., Mansouri, A., Mori, S., Sugawara, S., Adachi, S., Nishikawa, S.-I., and Gruss, P. (1999) Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397, 702-706.

 

神経・細胞薬理学分野 (Cell Pharmacology)

Suwa, H., Ohshio, G., Imamura, T., Watanabe, G., Arii, S., Imamura, M., Narumiya, S., Hiai, H. & Fukumoto, M. (1998)Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br. J. Cancer, 77, 147-152

Altun-Gultekin, Z.F., Chandriani, S., Bougeret, C., Ishizaki, T., Narumiya, S., de Graaf, P., van Bergen en Henegouwen, P., Hanafusa, H., Wagner, J.A. & Birge, R.B. (1998) Activation of rho-dependent cell spreading and focal adhesion biogenesis by v-Crk adaptor protein. Mol. Cell. Biol., 18, 3044-3058

Segi, E., Sugimoto, Y., Yamasaki, A., Aze, Y., Oida, H., Nishimura, T., Murata, T., Ushukubi, F., Fukumoto, M., Tanaka, T., Yoshida, N., Narumiya, S. & Ichikawa, A. (1998) Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem. Biophys. Res. Commun., 246, 7-12

Narumiya, S. (1998) Rho effectors mediating reorganization of actin cytoskeleton. In "Cytoskeleton and G-proteins in the Regulation of Cancer" (Kuzumaki, N, ed.), pp.107-110

Wijk, T. V. D., Dorrestijn, J., Narumiya, S., Maassen, J. A., De Jonge, H. R., and Tilly, B. C. (1998) Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in Intestine 407 cells involves the Ras/Raf-signalling pathway.Biochem J., 331, 863-869

Fujisawa, K., Madaule, P., Ishizaki, T., Watanabe, G., Bito, H., Saito, Y., Hall, A. & Narumiya, S. (1998) Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. J. Biol. Chem., 273, 18943-18949

Madaule, P., Eda, M., Watanabe, N., Fujisawa, K., Matsuoka, T., Bito, H., Ishizaki, T. & Narumiya, S. (1998) Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature, 394, 491-494

Tominaga, T., Ishizaki, T., Narumiya, S. and Barber, D.L. (1998) p160ROCK mediates RhoA activation of Na-H exchange. EMBO J., 17, 4712-4722

Hirose, M., Ishizaki, T., Uehata, M., Kranenburg, O., Moolenaar, W.H., Matsumura, F., Maekawa, M., Bito, H. and Narumiya, S. (1998) Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J. Cell Biol., 141, 1625-1636

Busca, R., Bertolotto, C., Abbe, P., Englaro, W., Ishizaki, T., Narumiya, S., Boquet, P.,Ortonne, J.P., and Ballotti, R. (1998) Inhibition of RHO is required for cAMP-induced melanoma cell differentiation. Mol. Biol. Cell, 6, 1367-1378

Ushikubi, F., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Segi, E., Hizaki, K., Ichikawa, A., Tanaka, T., Yoshida, N. and Narumiya, S. (1998) Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature, 395, 281-284

Yamaguchi, M., Nakamoao, M., Honda, H., Makagawa, T., Fujita, H., Nalamura, T., Hirai, H., Narumiya, S. and Kakizuka, A. (1998) Retardation of skeletal development and cervical abnormalities in transgenic mice expressing a dominant negative retinoic acid receptor in chondrogenic cells. Proc. Natl. Acad. Sci. USA, 95, 7491-7496

Furuyashiki, T., Fujisawa, K., Fujita, A., Madaule, P., Uchino, S., Mishina, M., Bito, H, and Narumiya, S. (1998) Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J. Neuroscience, 19, 109-118

Takeda, H., Matozaki, T., Fujioka, Y., Takada, T., Noguchi, T., Yamano, T., Tsuda, M., Ochi, F., Fukunaga, K., Narumiya, S., and Kasuga, M. (1998) Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK and a SRC family kinase. Oncogene, 16, 3019-3027

Segawa, T., Takebayashi, H., Kakehi, Y., Yoshida, O., Narumiya, S. and Kakizuka, A. (1998) Prostate-specific amplification of expandedpolyglutamine expression: a novel approach for cancer gene therapy. Cancer Res., 58, 2282-2287

Tanaka T, Tatsuno I, Noguchi Y, Uchida D, Oeda T, Narumiya S, Yasuda T, Higashi H, Kitagawa M, Nakayama K, Saito Y, Hirai A (1998) Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. J. Biol. Chem. 273, :6772-6778

Tsuzuki S, Toyama-Sorimachi N, Kitamura F, Tsuboi H, Ando J, Sakurai T, Morii N, Narumiya S, Miyasaka M. (1998) Intracellular Signal-transducing elements involved in transendothelial migration of lymphoma cells. Jpn. J. Cancer Res., 8, 571-577

Sugimoto Y, Segi E, Tsuboi K, Ichikawa A, Narumiya S (1998) Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition. Adv. Exp. Med. Biol., 449, 317-321

Itoh, K., Yoshioka, K., Akedo, H., Uehata, M., Ishizaki, T., and Narumiya, S. (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature Med., 5, 221-225

Sahai, E., Ishizaki, T., Narumiya, S. and Treisman, R. (1999) Transformation mediated by RhoA requires ROCK family kinase activity. Curr. Biol., 9, 136-145

Murakami, H., Iwashita, T., Asai, N., Iwata, Y., Narumiya, S. and Takahashi, M. (1999) Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxilin and p130cas mediated by Ret kinase. Oncogene, 18, 1975-1982

Narumiya, S., Sugimoto, Y., and Ushikubi, F. (1999) Prostanoid receptors; structures, properties and functions. Physiol. Rev. 79,1193-1226

Suzuki, Y., Yamamoto, M., Wada, H., Ito, M., Nakano, T., Sasaki, Y., Narumiya, S., Shiku, H., and Nishilawa, M. (1999) Agonist-induced regulation of myosin phosphatase activity in human platelet through activation of Rho-kinase. Blood, 93, 3408-3417

Nakamura, K., Fujita, A., Murata, T., Watanabe, G., Mori, C., Fujita, J., Watanabe, N., Ishizaki, T., Yoshida, O. and Narumiya, S. (1999) Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of sperm tail. FEBS Lett., 445, 9-13

Murata, T., Tanaka, H., Nagamatsu, T., Matsuoka, T., Luo, Z., Tanaka, T., Aze, Y., Tanaka, T., Yoshida, N., Segi, E., Sugimoto, Y., Suzuki, Y., Nagai, H., Miyasaka, M., Ushikubi, F., and Narumiya, S. (1999)

Lymphoproliferation and enhanced immune responses in mice lacking the thromboxane receptor. Nature, submitted

Watanabe, N., Kato, T., Fujita, A., Ishizaki, T. and Narumiya, S. (1999) Cooperation between mDia and ROCK in Rho-induced actin reorganization. Nature Cell Biol., 1, 136-143

Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., and Narumiya, S. (1999) Signalling form Rho- to the actin cytoskeleton through protein kinases ROCK and LIM-kinase Science, 285, 895-898

Hizaki, H., Srgi, E., Sugimoto, Y., Hirose, M., Saji, T., Ushikubi, F., Matsuoka, T., Noda, Y., Tanaka, T., Yoshida, N., Narumiya, S. and Ichikawa, A. (1999) Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2.Proc. Natl. Acd. Sci. USA, 96, 10501-10506

Shiraishi, Y., Mizutani, A., Bito, H., Fujisawa, K., Narumiya, S., Mikoshiba, K., and Furuichi, T. (1999) Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and cativated Rho family small GTPases and is expessed in developing mouse cerebellar granule cells. J. Neuroscience, 19, 8389-400.

Miyaura, C., Inada, M., Suzawa, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., and Suda, T. Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. J. Biol. Chem., submitted

Genda, T., Sakamoto, M., Ichida, T., Asakura, H., Kojiro, M., Narumiya, S., and Hirohashi, S. Cell motility mediated by Rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of hepatocellular carcinoma.Hepatology, 30, 1027-1036

Sakuma, Y., Tanaka, K. Suda, M., Yasoda, A., Natsui, K., Tanaka, I., Ushikubi, F., Narumiya, S., Segi, E., Sugimoto, Y., Ichikawa, A. and Nakao, K. (1999) Crucial involvement of EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokiines and lipopolysaccharide. J. Bone Mineral Res. In press

Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., and Narumiya, S. Pharmacological properties of Y-27632, a specific inhibitor of Rho-^associated kinase. Mol. Pharmacol., submitted

Fujita, A., Nakamura, K., Kato, T., Watanabe, N., Ishizaki, T., Kimura, K., Mizoguchi, A., and Narumiya, S. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J. Cell Sci., in press

Ishibashi, R., Tanaka, I., Kotani, M., Muro, S., Goto, M., Sugawara, A., Mukoyama, M., Sugimoto, Y., Ichikawa, A., Narumiya, S. and Nakao, K. (1999) Roles of prostaglandin E receptors in mesangial cells underhigh-glucose conditions.Kidney Int. 56, 589-600

Takeuchi, K., Ukawa, H., Furukawa, O., Kawauchi, S., Araki, H., Sugimoto, Y., Ishikawa, A., Ushikubi, F. and Narumiya, S. (1999) Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice. J Physiol. Pharmacol. 50, 155-167

 

認知行動脳科学分野 (Integrative Brain Science)

Inoue T, Kawaguchi S and Kurisu K (1998) Spontaneous regeneration of thepyramidal tractaftertransection in young rats. Neurosci Lett.247: 151-154

Asada Y, Kawaguchi S, Hayashi H and Nakamura T (1998) Neural repair of the injured spinal cord by grafting: comparison between peripheral nervesegments and embryonic homologous structures as a conduit of CNS axons. Neurosci Res 31: 241-249

Kikukawa S, Kawaguchi S, Mizoguchi A, Ide C and Koshinaga M (1998) Regeneration of dorsal column axons after spinal cord injury in young rats. Neurosci Lett 249: 135-138

Ito J, Nakajima K and Mori S (1998) Changes in locomotor movements after labyrinthectomy in the rat. Neurosci Res 32: 343-347

Ito J, Kawaguchi S, Nakajima K and Mori S (1998) Axonal regeneration with functional restoration in the vestibulospinal tract in young rats. Neurosci Res 32: 149-156

Ito J, Murata M and Kawaguchi S (1998) Spontanous regeneration and recovery of hearingfunction of the central auditory pathway in young rats. Neurosci Lett 254: 173-176

Ito J, Kawaguchi S & Murata M (1998) Regeneration of the auditory pathway in adult rats by transplants of fetal brain tissue. NeuroReport 9: 3815-3817

Arima K, Ogawa M, Sunohara N, Nishio T, Shimomura Y, Hirai S and Eto K (1998) Immunohistochemical and ultrastructural characterization of ubiquitinatedEosinophilic fibrillary neuronal inclusions in sporadic amyotrophic lateral sclerosis. Acta Neuropathol 96: 75-85

Nishio T, Furukawa S, Akiguchi I and Sunohara N (1998) Medial nigral dopamine neurons have rich neurotrophin support in humans. NeuroReport 9: 2847-2851

Nishio T, Sunohara N & Furukawa S (1998) Neurotrophin switching in spinal motoneurons of amyotrophic lateral sclerosis. Neuroreport 9: 1661-1665

Nishio T, Sunohara N, Mizutani K, Akiguchi I and Furukawa S (1998) Nerve growth factor levels in the cerebrospinal fluids are high in the inflammatory neurological disorders. Clin Chim Acta 275: 93-98

Nishio T, Sunohara N, Furukawa S, Akiguchi I and Kudo Y (1998) Repeated injections of nicergoline increase the nerve growth factor level in the aged rat brain. Jpn J Pharmacol 76: 321-323

Nishio T, Sunohara N, Nonaka I, Tsujino S and Sugie H (1998) Myophosphorylasedeficiency and limb-girdle muscular dystrophy in the same pedigree. Acta Neurol Scand 98: 364-367

川口三郎 (1998) 中枢神経系の再生の困難さとその克服. 脳の科学 20: 1165-1173

伊藤壽一 (1998) 脳幹聴覚中枢周辺の再生, 可塑性. Otology Japan 8: 146-149

伊藤壽一 (1998) 哺乳動物の中枢神経系の再生. 脳の科学 20: 1175-1182

有馬邦正, 西尾健資 (1998) 皮質下梗塞と白質脳症を伴う常染色体優性遺伝性脳動 脈症 (CADASIL)と頭痛. 内科 81: 705-707

Murata M, Kato N, Isomura Y & Hirota K (1998) Inhibition of neurite elongation of cortical neuron by antioxidant N-Acetyl Cysteine (NAC). Neurosci Res Suppl.22: S290

Isomura Y & Kato N (1998) Intracellular calcium dynamics eleicited by high-frequency synaptic stimulation in rat hippocampal dentate granule cells. Neurosci Res Suppl.22: S317

Soki K, Kawaguchi S, Mizoguchi A, Ide C & Koshinaga M (1998) Regeneration of dorsal column axons after spinal cord injury in young rats. Neurosci Res Suppl.22: S317

Ito J, Murata M & Kawaguchi S (1998) Regeneration and recovery of hearing function of the central auditory pathway in the adult rats. Neurosci Res Suppl.22: S317

Ito J, Murata M and Kawaguchi S (1999) Regeneration of the central auditory pathway in adult rats Acta Otolaryngol (Stockh). 119: 132-134

Isomura Y, Hashimoto K, Yamamoto K, Kato N (1999) Developmental regulation of action potential-induced Ca2+ entry in neocortical neurons. NeuroRepor 10: 1947-1950.

Isomura Y, Yamamoto K, Hashimoto K, Kato N (1999) Postnatal development of action potential-induced dendritic calcium entry in neocortical layer II/III pyramidal cells. Brain Res 832: 175-178.

Kato N, Tanaka T, Yamamoto K, Isomura Y (1999) Enhancement of activity-dependent calcium increase by neurotrophin-4 in visual cortex pyramidal neurons. Brain Res 832: 179-183.

Kato N, Tanaka T, Yamamoto K, Isomura Y (1999) Distinct temporal profiles of activity-dependent calcium increase in pyramidal neurons of the rat visual cortex. J Physiol (Lond) 519: 467-479.

Isomura Y, Kato N (1999) Action potential-Induced dendritic calcium dynamics correlated with synaptic plasticity in developing hippocampal pyramidal cells. J Neurophysiol 82: 1993-1999.

Hashimoto K, Isomura Y, Kato N (1999) Occurrence of dentate granule cell LTP without proximal dendritic Ca2+ increase. NeuroReport 10: 2509-2513.

Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K & Yodoi J (1999) Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus. A Two-step mechanism of redox regulation of transcription factor NF-B. J Biol Chem 274: 27891-27897

Kawaguchi S, Kojima K, Hasebe T, Kikukawa S, Murata M and Iwashita Y (1999) Spinal cord repair in adult rats: restoration of corticospinal and rubrospinal tracts to almost normal extent. In "Neural Development, Keio University Symposia for Life Science and Medicine 2" Eds. Uemura K, Kawamura K, and Yazaki T, , Springer Verlag, p.506.

川口三郎(1999) 損傷脊髄伝導路の再生の困難さとその克服. 脊椎脊髄ジャーナル12: 395-404.

川口三郎(1999) 神経修復. 学術月報52: 1268-1271.

川口三郎(1999) 小脳の機能. In 別冊・医学のあゆみ 神経疾患−states of arts ver.1 (中村重信 編) 医歯薬出版 東京15-18.

Nishio T. (1999) Developmental change of caspase activity in the rat spinal cord. Jpn J Physiol 49 Suppl. S47.

Yoshimura H, Kato N (1999) Various roles of intracellular cAMP on synaptic modification in the visual cortex. Jpn J Physiol 49 Suppl: S142.

Isomura Y, Kato N (1999) Developmental enhancement of action potential-induced dendritic calcium increases in hippocampal CA1 pyramidal cells. Jpn J Physiol 49 Suppl: S143.

Kojima K, Kawaguchi S, Hasebe T, Nishio T. (1999) Restoration of somatotopic organization in the regenerated rubrospinal tract in the rat. Jpn J Physiol 49 Suppl. S211.

Hasebe T, Kawaguchi S, Kojima K, Nishio T. (1999) Synaptogenesis of regenerated rubrospinal tract fibers after spinal cord injury in adult rats. Jpn J Physiol 49 Suppl. S211.

Isomura Y, Hashimoto K, Yamamoto K, Kato N (1999) Developmental regulation of action potential-induced celcium dynamics in neocortical layer II/III and layer V pyramidal neurons. Neurosci Res Suppl 23: S128.

Kawaguchi S, Nishio T, Hase T, Kawasaki T, Kojima K, Hasebe T. (1999) Spinal cord repair in adult paraplegic rats: Locomotor assessment and electromyographic study. Neurosci Res 23 Suppl. S175.

Kojima K, Kawaguchi S, Hasebe T, Nishio T. (1999) Conditions determining extent of regeneration and restoration of somatotopic organization in the rubrospinal tract of adult rats. Neurosci Res 23 Suppl. S178.

Koyama N, Nishio T, Yokota T. (1999) Mesencephalic neurons expressing c-Fos after systemic picrotoxin injection are nonserotonergic. Neurosci Res 23 Suppl. S221.

Isomura Y, Kato N (1999) Dendritic calcium dynamics and susceptibility to LTP are correlated in developing hippocampal CA1 pyramidal cells. Soc Neurosci Abst 25: 985.

Nishio T, (1999) Cellular localization of neurotrophin 3 and trkC mRNA in autopsied human cerebella. Neuropathology, 19 Suppl. A11.

西尾健資(1999)神経変性疾患患者剖検脳におけるApoptosis関連分子の定量的検討. 臨床神経学39:1438.

 

脳神経外科学分野 (Neurosurgery)

Takagi.Y., Tokime.T., Nozaki.K., Gon.Y., Kikuchi.H., Yodoi.J. Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat: Immunohistochemical and hydridization studies of thioredoxin. J Cereb Blood Flow Metab 18:206-214,1998

齋木雅章、宮武伸一、美馬達夫、菊池晴彦、橋本信夫、Adenovirus vector により変異型増殖因子受容体導入を行う悪性脳腫瘍に対する(302) 遺伝子治療の試み 臨床薬理の進歩'98:107-111,1998

Tokime.T., Nozaki.K., Sugino.T., Kikuchi.H., Hashimoto.N., Ueba.K. Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain. J Cereb Blood Flow Metab 18:991-997,1998

Yukawa.H., Miyatake.S., Saiki.M., Takahashi.JC., Mima.T., Ueno.H., Nagata.I., Kikuchi.H., Hashimoto.N. In vitro growth suppression of vascular smooth muscle cells using adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor. Atherosclerosis 141:125-132,1998

Kojima.M., Asahi.M., Kikuchi.H., Hashimoto.N., Noda.M., Hoshimaru.M. Expression of Nedd2/ICH-1(caspase-2) in the developing rat retina. Neuroscience Research 31:211-217,1998

Yanamoto.H., Nagata.I., Hashimoto.N., Kikuchi.H. Three-vessel occlusion using a micro-clip for the proximal left middle cerebral artery produces areliable neocortical infarct in rats. Brain Research Protocols 3:209-220,1998

田代弦、井陽輝、Shushovan Chakrabortty、橋本信夫、シャント設置による水頭症ラット大脳皮質の機能回復 小児の脳神経 23:224-230,1998

田代弦、James M.Drake、井陽輝、橋本信夫、水頭症ラット大脳皮質におけるCa-binding protein 免疫陽性細胞のシャント前後(328)の機能変化 神経免疫研究 11:11-14,1998

Kondo.So., Hashimoto.N., Kikuchi.H., Hazama.F., Nagata.I., Kataoka.H. Apoptosis of medial smooth muscle cells in the development of saccular cerebral aneurysms in rats. Stroke 29:181-189,1998

Takagi.Y.,Gon.Y., Todaka.T., Nozaki.K., Nishiyama.A., Sono.H., Hashimoto.N., Kikuchi.H., Yodoi.J. Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries. Lab Invest 78:957-966,1998

Tani.S., Taniwaki.M., Taniguchi.Y., Minoguchi.S., Kuroda.K., Hua Han, Aoki.T., Miyatake.S., Hashimoto.N., Honjo.T. Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L J Hum Genet 44:73-75,1999

Akimoto.M., Miyatake.S., Kogishi.J., Hangai.M., Okazaki.K., Takahashi.JC., Saiki.M., Iwaki.M., Honda.Y. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats Invest Ophthalmol Vis Sci 40:273-279,1999

Takagi.Y., Mitsui.A., Nishiyama.A., Nozaki.K., Sono.H., Gon.Y., Hashimoto.N., Yodoi.J. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage Proc. Natl.Acad.Sci.USA 96:4131-4136,1999

Takagi.Y., Nozaki.K., Takahashi.J.,Yodoi.J., Ishikawa.M., Hashimoto.N. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice Brain Research 00:000-000,1999

Kataoka.H., Kume.N., Miyamoto.S., Minami.M., Moriwaki.H., Murase.T., Sawamura.T., Masaki.T., Hashimoto.N., Kita.T. Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions Circulation 99:3110-3117,1999

橋本信夫、実験的脳動脈瘤、Clinical Neuroscience 17:624-626,1999

橋本信夫、脳動脈瘤の発生機序、綜合臨牀 48:1850-1851,1999

Takagi.Y., Nakamura.T., Nishiyama.A., Nozaki.K., Tanaka.T., Hashimoto.N., Yodoi.J. Localization of glutaredoxin (Thioltransferase) in the rat brain and possible functional implecations during focal ischemia. Biochemical and Biophysical Research Communications 258:390-394,1999

Takagi.Y., Nozaki.K., Takahashi.J., Yodoi.J., Ishikawa.M., Hashimoto.N. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Research 831:283-287,1999

Sugino.T., Nozaki.K., Takagi.Y., Hashimoto.N. 3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo. Neuroscience Letters 259:9-12,1999

Matsuoka.N., Yukawa.H., Ishii.K., Hamada.H., Akimoto.M., Hashimoto.N., Miyatake.S. Adenovirus-mediated gene transfer of Bcl-xL prevents cell death in primary neuronal culture ofthe rat. Neuroscience Letters 270:177-180,1999

Ueno.Y., Kume.N., Miyamoto.S., Morimoto.M., Kataoka.H., Ochi.H., Nishi.E., Moriwaki.H., Minami.M., Hashimoto.N., Kita.T. Lysophosphatidylcholine phosphorylates CREB and activates the jun2TRE site of c-jun promoter in vascular endothelial cells. FEBS Letters 457:241-245,1999

橋本信夫、脳動脈瘤の成因と治療に関する研究、神経進歩 43:832-837,1999

Sugino.T., Nozaki.K., Takagi.Y., Hattori.I., Hashimoto.N., Yodoi.J. Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain. Neuroscience Letter 275:145-148,1999

Saiki.M., Mima.T., Takahashi.JC., Tani.S., Yukawa.H., Ueno.H., Mikawa.T., Itoh.N., Kikuchi.H., Hashimoto.N., Miyatake.S. Adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor inhibits growth of glioma cells both in vitro and in vivo. Journal of Neuro-Oncology 44:195-203,1999

Miyatake.S., Yukawa.H., Toda.H., Matsuoka.N., Takahashi.R., Hashimoto.N. Inhibition of rat vascular smooth muscle cell proliferation in vitro and in vivo by recombinant replication-competent herpes simplex virus. Stroke 30:2431-2439,1999

 

病態代謝栄養学分野 (Metabolism and Clinical Nutrition)

Mukai, E., Ishida, H., Kato, S., Tsuura, Y., Fujimoto, S., Ishida-Takahashi, A., Horie, M., Tsuda, K., and Seino, Y. (1998). Metabolic inhibition impairs ATP-sensitive K+ channel block by sulfonylurea in pancreatic b cells. Am. J. Physiol. (Endocrinol. Metab.), 274(1): E38-44.

Nishimura, M., Ishida, H., Tsuura, Y., Kato, S., Mizuno, N., Fujimoto, S., Fukai, E., Kajikawa, M., Usami, M., and Seino, Y. (1998). Necessity of endogenous GTP derived from glucose-6-phosphate for insulin secretion augmented by glucose under protein kinase A activation. Biochem. Biophys. Res. Commun., 243(1): 253-257.

Fujimoto, S., Ishida, H., Kato, S., Okamoto, Y., Tsuji, K., Mizuno, N., Ueda, S., Mukai, E., and Seino, Y. (1998). The novel insulinotropic mechanism of pimobendan:direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in b-cells. Endocrinology, 139(3): 1133-1140.

Tsuura, Y., Ishida, H., Nishimura, M., Fujimoto, S., Kajikawa, M., and Seino, Y. (1998). Ouabain suppresses ATP elevation in response to fuel secretagogues in pancreatic islets. Biochem. Biophys. Res. Commun., 249(3): 853-857.

Ishida, H., Kato, S., Nishimura, M., Mizuno, N., Fujimoto, S., Mukai, E., Kajikawa, M., Yamada, Y., Okada, H., Ikeda, H., and Seino, Y. (1998). Beneficial effect of long-term combined treatment with voglibose and pioglitazone on pancreatic islet function of genetically diabetic GK rats. Horm. Metab. Res., 30(11): 673-678.

Tsuura, Y., Ishida, H., Shinomura, T., Nishimura, M., and Seino, Y. (1998). Endogenous nitric oxide inhibits glucose-induced insulin secretion by suppression of phosphofructokinase activity in pancreatic islets. Biochem. Biophys. Res. Commun., 252(1): 34-38.

Fukuda, K., Tsukada, H., Oya, M., Onomura, M., Kodama, M., Nakamura, H., Hosokawa, M., and Seino, Y. (1998). Effect of adrenomedulin on ion transport and muscle contraction in rat distal colon. Peptides, 19(6): 1043-1047.

Hosokawa, M., Tsukada, H., Saito, T., Kodama, M., Onomura, M., Nakamura, H., Fukuda, K., and Seino, Y. (1998). Effects of okadaic acid on rat colon. Dig. Dis. Sci. 42(11): 2526-2535.

Taniguchi, T., Tsukada, H., Nakamura, H., Kodama, M., Fukuda, K., Saito, T., Miyasaka, M., and Seino, Y. (1998). Effects of the anti-ICAM-1 monoclonal antibody on dextran sodium sulphate-induced colitis in rats. J. Gastroenterol Hepat 13(9): 945-949.

Inada, A., Yamada, Y., Someya, Y., Kubota, A., Yasuda, K., Ihara, Y., Kagimoto, S., Kuroe, A., Tsuda, K., and Seino, Y. (1998). Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats. Biochem. Biophys. Res. Commun. 253(3): 712-718.

Fukuda, K., Tsukada, H., Oya, M., Onomura, M., Kodama, M., Nakamura, H., Hosokawa, M., and Seino, Y. (1999). Adrenomedulin promotes epithelial restitution of rat and human gastric mucosa in vitro. Peptides 20(1): 127-132.

Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., Hiai, H., Seino, Y., and Yamada, Y. (1999). Hyperglycemia causes oxidative stress in pancreatic b-cells of GK rats, a model of type 2 diabetes. Diabetes 48(4): 927-932.

Watanabe, R., Yamada, Y., Ihara, Y., Someya, Y., Kubota, A., Kagimoto, S., Kurose, A., Iwakura, T., Shen, Z.P., Inada, A., Adachi, T., Ban, N., Miyawaki, K., Sunaga, Y., Tsuda, K., and Seino, Y. (1999). The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals. Biochem. Biophys. Res. Commun. 254(3): 707-712.

Inada, A., Someya, Y., Yamada, Y., Ihara, Y., Kubota, A., Ban, N., Watanabe, R., Tsuda, K.., and and Seino, Y. (1999). The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. J. Biol. Chem. 74(30): 21095-21103.

Tsuura, Y., Fujimoto, S., Kajikawa, M., Ishida, H., and Seino, Y. (1999). Regulation of intracellular ATP concentration under condition of reduced ATP consumption in pancreatic islets. Biochem. Biophys. Res. Commun. 261(2): 439-444.

Kajikawa, M., Ishida, H., Fujimoto, S., Nishimura, M., Fujita, J., Tsuura, Y., Okamoto, Y., Norman, A.W., and Seino, Y. (1999). An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic b cells through non-genomic signal transduction. Endocrinology 140(10): 4706-4712.

Hosokawa, M., Tsukada, H., Fukuda, K., Oya, M., Onomura, M., Nakamura, H., Kodama, M., Yamada, Y., and Seino, Y. (1999). Troglitazone inhibits bicarbonate secretion in rat and human duodenum. J. Pharmacol. Exp. Ther. 290(3): 1080-1084.

Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kurose, A., Tsuda, K., Hashimoto, H., Yamashita, T., Jomori, T., Tashiro, F., Miyazaki, J. and Seino, Y.(1999). Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice. Proc. Natl. Acad. Sci. USA 96(26): 14843-14847.

 

臨床病態医科学分野 (Medicine and Clinical Science)

Suda, M., Ogawa, Y., Tanaka, K., Tamura, N., Yasoda, A., Takigawa, T., Uehira, M., Nishimoto, H., Itoh, H., Saito, Y., Shiota, K., and Nakao, K. (1998). Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide. Proc. Natl. Acad. Sci. USA, 95, 2337-2342.

Harada, M., Saito, Y., Kuwahara, K., Ogawa, E., Ishikawa, M., Nakagawa, O., Miyamoto, Y., Kamitani, S., Hamanaka, I., Kajiyama, N., Masuda, I., Itoh, H., and Nakao, K. (1998). Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture. J. Cardiovasc. Pharmacol., 31(Suppl 1), s357-s359.

Kuwahara, K., Saito, Y., Ogawa, Y., Tamura, N., Ishikawa, M., Harada, M., Ogawa, E., Miyamoto, Y., Hamanaka, I., Kamitani, S., Kajiyama, N., Takahashi, N., Nakagawa, O., Masuda, I., and Nakao, K. (1998). Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms. J. Cardiovas. Pharmacol., 31(Suppl. 1) , s354-s356.

Masuzaki, H., Ogawa, Y., Aizawa-Abe, M., Hosoda, K., Suga, J., Ebihara, K., Satoh, N., Iwai, H., Inoue, G., Nishimura, H., Yoshimasa, Y., and Nakao, K. (1999). Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: Usefulness of leptin for the treatment of obesity-associated diabetes. Diabetes, 48, 1615-1622.

Ogawa, Y., Masuzaki, H., Hosoda, K., Aizawa-Abe, M., Suga, J., Suda, M., Ebihara, K., Iwai, H., Matsuoka, N., Satoh, N., Odaka, H., Kasuga, H., Fujisawa, Y., Inoue, G., Nishimura, H., Yoshimasa, Y., and Nakao, K. (1999). Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes, 48, 1822-1829.

Harada, E., Nakagawa, O., Yoshimura, M., Harada, M., Nakagawa, M., Mizuno, Y., Shimasaki, Y., Nakayama, M., Yasue, H., Kuwahara, K., Saito, Y., and Nakao, K. (1999). Effect of interleukin-1 beta on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture. J. Mol. Cell. Cardiol. 31, 1997-2006.

Ishikawa, M., Saito, Y., Miyamoto, Y., Harada, M., Kuwahara, K., Ogawa, E., Nakagawa, O., Hamanaka, I., Kajiyama, N., Takahashi, N., Masuda, I., Hashimoto, T., Sakai, O., Hosoya, T., and Nakao, K. (1999). Heart-specific increase in cardiotrophin-1 gene Expression precedes establishment of ventricular hypertension in genetically hypertensive rats. J. Hypertens., 17, 807-816.

Kuwahara, K., Saito, Y., Nakagawa, O., Kishimoto, I., Harada, M., Ogawa, E., Miyamoto, Y., Hamanaka, I., Kajiyama, N., Takahashi, N., Izumi, T., Kawakami, R., Tamura, N., Ogawa, Y., and Nakao, K. (1999). The Effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic responses in neonatal rat cardiac myocytes -possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy-. FEBS Lett. 452, 314-318.

Kuwahara, K., Saito, Y., Harada, M., Ishikawa, M., Ogawa, E., Miyamoto, Y., Hamanaka, I., Kamitani, S., Kajiyama, N., Takahashi, N., Nakagawa, O., Masuda, I., and Nakao, K. (1999). Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro. Circulation, 100, 1116-1124.

Mori, K., Ogawa, Y., Ebihara, K., Tamura, N., Tashiro, K., Kuwahara, T., Mukoyama, M., Sugawara, A., Ozaki, S., Tanaka, I., and Nakao, K. (1999). Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. J. Biol. Chem., 274, 15701-15705.

Ishibashi, R., Tanaka, I., Kotani, M., Muro, S., Goto, M., Sugawara, A., Mukoyama, M., Sugimoto, Y., Ichikawa, A., Narumiya, S., and Nakao, K. (1999). Roles of prostaglandin E receptors in mesangial cells under high glucose conditions. Kidney Int., 56, 589-600, 1999.

 

循環病態学分野(Cardiovascular Medicine)

Nohara R, Hosokawa R, Hirai T, Okuda K, Ogino M, Fujibayashi Y, Fujita M, Sasayama S. (1998). Effect of metabolic substrate on-BMIPP metabolism in canine myocardium. J Nucl Med, 39, 1132-1137

Nohara R, Hosokawa R, Hirai T, Okuda K, Ogino M, Fujibayashi Y, Fujita M, Sasayama S. (1999). Basic kinetic of 15-(p-iodophenyl)-3-R, -methylpentadecanoic acid (BMIPP) in canine myocardium. Int Cardiac Imaging, 15, 11-20

Hosokawa R, Nohara R, Fujibayashi Y, Okuda K, Ogino M, Hirai T, Fujita M, Tamaki N, Konishi J. (1999). Myocardial metabolism of iodine-123-BMIPP in a canine model with ischemia : Implications of perfusion-metabolism mismatch on SPECT images in patients with ischemic heart disease. J Nucl Med, 40, 471-478

 

消化器病態学分野 (Gastroenterology and Hepatology)

Y.Kinoshita, S.Hassan, M.Kawamura, Y.Matsushima, A.Okada, T.Maekawa, H.Fukui, S.Waki, K.Kishi, T.Chiba. Increased hepatocyte growth factor content in rat stomach during omeprazole treatment. Digestion 59, 102-109, 1998.

S.Waki, Y.Kinoshita, He-Yao Wang, M.Asahara, Y.Matsushima, S.Hassan, A.Okada, T.Maekawa, H.Fukui, C.Kawanami, K.Kishi, T.Chiba. Effect of aging on gastrin receptor gene expression in rat stomach. Peptides 19, 225-229, 1998.

Y.Kinoshita, H.Nakata, K.Kishi, C.Kawanami, M.Sawada, T.Chiba. Comparison of the signal transduction pathways activated by gastrin in enterochromaffin-like and parietal cells. Gastoroenterology 115, 93-100, 1998.

M.Ohana, K.Okazaki, K.Hajiro, K.Uchida. Anti-lactoferrin antibodies in autoimmune liver diseases. Am J Gastroenterol 93, 1334-9, 1998.

Y.Hoshihara, C.Kawanami.. Duodenumand small intestine. Atlas of Gastroenterologic Endoscopy K.Nagasako,(ed), Igaku-shoin,80-98,1998.

Y.Morita, M.Sawada, S.Takaishi, H.Seno, H.Fukuzawa, N.Miyake, H.Hiai, T.Chiba. Identification and characterization of zinc-binding protein in rat paneth cells. Gastroenterology 116, A737, 1999.

T.Chiba. Is the function of chief cells closely influenced by ECL cells? J Gastroenterol 34, 424-425, 1999.

H.Nakase, T.Itani, J.Mumura, T.Kawasaki, H.Komori, K.Hashimoto, T.Chiba. Colonic ulceration caused by administration of loxoprofen sodium. Internal Medicine 38, 249-251, 1999.

Y.Konda, H.Kanimura, T.Chiba, T.Takeuchi. Direct growth stimulatory effect of gastrin on gastric surface mucous cells. Digestion60, 613, 1999.

Y.Konda, H.Kamimura, H.Yokota. Gastrin stimulates the growth of gastric pit with less-differentiated features. American Jouenal Physiology 277, G1773-84, 1999.

 

加齢医学分野 (Geriatric Medicine)

Shizuka Sakata-Kaneko, Yoshio Wakatsuki, Takashi Usui. Yoichi Matsunaga, Toshiyuki Itoh, Eiichiro Nishi, Noriaki Kume, Toru Kita : Lysophosphatydylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells. FEBS Letters 1998, 433:161-165

若月芳雄、Helicobacter pylori 感染と宿主の免疫反応、組織培養工学 99年 7月号 1999, 25(8);13-16

若月芳雄、小腸上皮細胞間リンパ球の活性化機構、 臨床科学 1998, 34:1653-1661

伊藤俊之、若月芳雄、Helicobactor pylori 感染胃粘膜における宿主の免疫応答 −T細胞応答を中心に、 医学のあゆみ 1998, 184:676-677

若月芳雄、H.pylori 感染宿主の免疫、Molecular Medicine, 1998. 35(3); 302-307

Toshiyuki Itoh, Yoshio Wakatsuki, Masaru Yoshida, Takashi Usui, Yoichi Matsunaga, Shizuka Kaneko, Tustomu Chiba andToru Kita : Gastric T cells are polarized to produce T helper 1 type cytkines upon antigenic stimulation even without Helicobacter pylori infection.. J. Gastroenterology 1999, 5:560-570

Mi-Na Kweon, Kohtaro Fujihashi, Yoshio Wakatsuki, Toshiya Koga, Masafumi Yamamoto, Jerrry R. McGhee and Hiroshi Kiyono: Mucosally Induced Systemic T Cell Unresponsiveness To Ovalbumin Requires CD40 ligand-CD40 Interactions J Immunol 1999, 162:1904-1909

Masaru Yoshida, Yoshio Wakatsuki, Yoshinao Kobayashi, Toshiyuki Ito, Kazuhisa Murakami, Akira Mizoguchi, Takashi Usui, Tsutomu Chiba, Toru Kita: Cloning and Characterization of a Novel Membrane- associated Antigenic Protein of Helicobactor pylori. Infection and Immunity 1999,67:286-293

若月芳雄、H.pylori 感染と胃粘膜の免疫応答、日本臨床 1999、57(1)23-31

若月芳雄、H.pylori 感染と生体防御、 別冊 医学のあゆみ 1999 生体応答学の新展開 p57-60

 

腫瘍放射線科学分野 (Therapeutic Radiology and Oncology)

Guo GZ, Sasai K, Oya N, Shibata T, Shibuya K, Hiraoka M. A significant correlation between clonogenic radiosensitivity and the simultaneous assessment of micronucleus and apoptotic cell frequencies. Int J Radiat Biol. 1999 Jul;75(7):857-64.

Shibuya K, Fujibayashi Y, Yoshimi E, Sasai K, Hiraoka M, Welch MJ. Cytosolic/microsomal redox pathway: a reductive retention mechanism of a PET-oncology tracer, cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (cu-PTSM). Ann Nucl Med. 1999 Oct;13(5):287-92.

Shibuya K, Sasai K, Xie X, Utsumi H, Shibata T, Hiraoka M. Detection of hypoxic cells in murine tumors using the comet assay: comparison with a conventional radiobiological assay. Jpn J Cancer Res. 1999 Aug;90(8):880-6.

Kanamori S, Nishimura Y, Okuno Y, Horii N, Saga T, Hiraoka M. Induction of vascular endothelial growth factor (VEGF) by hyperthermia and/or an angiogenesis inhibitor. Int J Hyperthermia. 1999 Jul-Aug;15(4):267-78.

Okuno Y, Nishimura Y, Kashu I, Ono K, Hiraoka M. Prognostic values of proliferating cell nuclear antigen (PCNA) and Ki-67 for radiotherapy of oesophageal squamous cell carcinomas. Br J Cancer. 1999 May;80(3-4):387-95.

Shibata T, Akiyama N, Noda M, Sasai K, Hiraoka M. Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):913-6.

Sasai K, Guo GZ, Shibuya K, Oya N, Shibata T, Nagata Y, Hiraoka M. Effects of SN-38 (an active metabolite of CPT-11) on responses of human and rodent cells to irradiation. Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):785-8.

Takagi T, Sasai K, Shibamoto Y, Akagi K, Oya N, Shibata T, Kim J, Hiraoka M. The influence of DNA ploidy of a human tumor cell line on the frequencies of micronuclei or chromosome aberrations after irradiation. Mutat Res. 1998 Sep 25;418(1):49-57.

Guo GZ, Sasai K, Oya N, Takagi T, Shibuya K, Hiraoka M. Simultaneous evaluation of radiation-induced apoptosis and micronuclei in five cell lines. Int J Radiat Biol. 1998 Mar;73(3):297-302.

 

核医学・画像診断学分野 (Nuclear Medicine and Diagnostic Imaging)

Nakamoto, Y., Saga, T., Sakahara, H., Yao, Z., Zhang, M., Sato, N., Zhao, S., Nakada, H., Yamashina, I., and Konishi, J. (1998). Three-step tumor imaging with biotinylated monoclonal antibody, streptavidin and In-111-DTPA-biotin. Nucl. Med. Biol., 25, 95-99.

Zhang, M., Yao, Z., Sakahara, H., Saga, T., Nakamoto, Y., Sato, N., Zhao, S., Nakada, H., Yamashina, I., and Konishi, J. (1998). Effect of administration route and dose of streptavidin or biotin on the tumor uptake of radioactivity in intraperitoneal tumor with multistep targeting. Nucl. Med. Biol., 25, 101-105.

Zhang, M., Yao, Z., Saga, T., Sakahara, H., Nakamoto, Y., Sato, N., Nakada, H., Yamashina, I., and Konishi, J. (1998). Improved intratumoral penetration of radiolabeled streptavidin in intraperitoneal tumors pretargeted with biotinylated antibody. J. Nucl. Med., 39, 30-33.

Yao, Z., Zhang, M., Sakahara, H., Saga, T., Arano, Y., and Konishi, J. (1998). Avidin targeting of intraperitoneal tumor xenografts. J. Natl. Cancer Inst., 90, 25-29.

Yao, Z., Zhang, M., Sakahara, H., Saga, T., Nakamoto, Y., Sato, N., Zhao, S., Arano, Y., and Konishi, J. (1998). Imaging of intraperitoneal tumors with technetium-99m GSA. Annals Nucl. Med., 12, 115-118.

Yao, Z., Zhang, M., Sakahara, H., Saga, T., Kobayashi, H., Nakamoto, Y., Toyama, S., and Konishi, J. (1998). Increased streptavidin uptake in tumors pretargeted with biotinylated antibody using a conjugate of streptavidin-Fab fragment. Nucl. Med. Biol., 25, 557-560.

Nakamoto, Y., Sakahara, H., Saga, T., Yao, Z., Zhang, M., Sato, N., Zhao, S., Arano, Y., Ono, M., Saji, H., and Konishi, J. (1998). A radiolabeled biocytin derivative for in-vivo applications. Nucl. Med. Commu, 19, 963-969.

Sato, N., Saga, T., Sakahara, H., Nakamoto, Y., Zhao, S., Iida, Y., Kuroki, M., Matsuoka, Y., and Konishi, J.(1999). Intratumoral distribution of radiolabeled antibody and radioimmunotherapy in experimental liver metastases model of nude mouse. J. Nucl. Med., 40, 685-692.

Saga, T., Sakahara, H., Nakamoto, Y., Sato, N., Zhao, S., Iida, Y., Kuroki, M., Endo, K., and Konishi, J.(1999). Radioimmunotherapy for liver micrometastases in mice: Pharmacokinetics, dose estimation, and long-term effect. Jpn. J. Cancer Res., 90, 342-348.

Nakamoto, Y., Sakahara, H., Saga, T., Sato, N., Zhao, S., Arano, Y., Fujioka, Y., Saji, H., and Konishi, J. (1999). A novel immunoscintigraphy technique using metabolizable linker with angiotensin II treatment. Brit. J. Cancer, 79, 1794-1799.

Sakahara, H., and Saga, T. (1999). Avidin-biotin system for delivery of diagnostic agents. Adv. Drug Deliv. Rev., 37, 89-101.

Kanamori, S., Nishimura, Y., Okuno, N., Horii, N., Saga, T., and Hiraoka, M. (1999). Induction of vascular endothelial growth factor (VEGF) by hyperthermia and/or an angiogenesis inhibitor. Int. J. Hyperthermia, 15, 267-278.

Saga, T., Sakahara, H., Nakamoto, Y., Sato, N., Zhao, S., Aoki, T., Miyatake, S., Namba, Y., and Konishi, J. (1999). Radioimmunotherapy of human glioma xenografts in nude mice by Indium-111 labelled internalising monoclonal antibody. Eur. J. Cancer, 35, 1281-1285.

 

消化器外科学分野 (Gastroenterological Surgery)

Yagi, T., Satoh, S., Kanazawa, A., Uesugi, T., Takeyama, O., Yoneyama, T., Nishitai, R., Terajima H., Ikai, I., Shimahara, Y., and Yamaoka, Y. (1998) Extracorporeal xenoperfusion of the pig liver as a liver assist device:Effects of prostaglandin E1 and soluble complement receptor type 1.Transplantation Proceedings,30,74-75.

Shimabukuro, T., Yamamoto, Y., Kume, M., Kimoto, S., Okamoto, R., Morimoto, T., and Yamaoka, Y. (1998). Induction of heat shock response: Effect on the rat liver with carbon tetrachloride-induced fibrosis from ischemia-reperfusion injury. W orld J Surg,22,464-469.

Yamamoto, Y., Kume, M., and Yamaoka, Y. (1998). Implications of heat shock preteins during liver surgery and liver perfusion. Rec Res Can Res,147,157-172.

Dai, C.L., Kume, M., Yamamoto, Y., Yamagami, K., Yamamoto, H., Nakayama, H., Ozaki, N., Shapiro, A.M.J., Yamamoto, M., and Yamaoka, Y. (1998). Heat shock protein 72 production in liver tissue after experimental total hepatic inflow occlusion. Br J Surg, 85,1061-1065.

Yamagami, K., Yamamoto, Y., Kume, M., Kimoto, S., Yamamoto, H., Ozaki, N., Yamamoto, M., Shimahara, Y., Toyokuni, S., and Yamaoka, Y. (1998). Heat schok preconditioning ameliorates liver injury following normothermic ischemia-reperfusion in steatotic rat livers. J Surg Res,79,47-53.

Terao, R., Honda, K., Hatano, E., Uehara, T., Yamamoto, M., and Yamaoka, Y. (1998). Suppression of proliferative cholangitis in a rat model with direct adenovirus-mediated retinoblastoma gene transfer to the biliary tract. Hepatology,28,605-612.

Tsuyuki, S., Yamauchi, Y., Nakamura, H., Nakamura, Y., Kinoshita, K., Gomi, T., Kawai, Y., Hirose, T., Furuke, K., Ikai, I., Ohmori, K., Yamaoka, Y., and Inamoto., T. (1998). N-acetylcysteine improves cytotoxic activity of cirrhotic rat liver-associated mononuclear cells. Int Immun,10,1501-1508.

Kanazawa, A., Tanaka, A., Iwata, S., Satoh, S., Hatano, E., Shinohara, H., Kitai, T., Tsunekawa, S., Ikai, I., Yamamoto, M., Takahashi, R., Chance, B., and Yamaoka, Y. (1998). The beneficial effect of phosphocreatine accumulation in the creatine kinase transgenic mouse liver in endotoxin-induced hepatic cell death. J Surg Res,80,229-235.

Yabe, S., Nishizawa, H., Egawa, H., Nakayama, H., Okamoto, S., Kiuchi, T., Uemoto, S., Asonuma, K., Shapiro, A.M.J., Inomata, Y., Yamaoka, Y., and Tanaka, K. (1999). Portal blood flow and liver regeneration in auxiliary partial orthotopic liver transplantation in a canine model. Eur Surg Res,31,83-92.

Uehara, T., Honda, K., Hatano, E., Terao, R., Iimuro, Y., Yamamoto, N., Yamamoto, M., Kaneda, Y., and Yamaoka, Y. (1999). Gene trasfer to the rat biliary tract with the HVJ-cationic liposome method. J Hepatol,30,836-842.

Iwai, M., Shinkura, N., Yamaoka, Y., Nakamura, K., Tamura, K., and Kobayashi, M. (1999). The identification of dominant epitopes of h-FKBP-12 recognized by monoclonal antibodies, 3F4 and 2C1, against h-FK-506 binding protein 12(h-FKBP-12). Peptide Science, 803-804.

Iwata, H., Sajiki, T., Maeda, H., Park, Y. G., Zhu, B., Uesugi, T., Ikai, I., Yamaoka, Y., and Ikada, Y. (1999). In vitro evaluation of metabolic functions of a bioartificial liver. ASAIO Journal, 45,299-306.

Uesugi, T., Ikai, I., Yagi, T., Satoh, S., Kanazawa, A., Yoneyama, T., Takeyama, O., Nishitai, R., Katura, N., Okabe, H., Terajima, H., Iwata, H., and Yamaoka, Y. (1999). Evaluation of ammonia and lidocaine clearance, and galactose elimination capacity of xenoperfused pig livers using a pharmacokinetic analysis. Transplantation, 68,209-214.

Nakayama, H., Yamamoto, Y., Kume, M., Yamagami, K., Hamamoto, H., Kimoto, S., Ishikawa, Y., Ozaki, N., Shimahara, Y., and Yamaoka, Y. (1999). Pharmacologic stimulation of adenosine A2 receptor supplants ischemic preconditioning in providing ischemic tolerance in rat livers. Surgery,126,945-954.

Ishikawa, Y., Yamamoto, Y., Kume, M., Yamagami, K., Yamamoto, H., Kimoto, S., Sakai, Y., Yamamoto, M., and Yamaoka, Y. (1999). Heat shock preconditioning on mitochondria during warm ischemia in rat livers. J Surg Res, 87,178-184.

 

婦人科学産科学分野 ( Gynecology and Obstetrics )

Nakamura, T., Fujiwara, H., Higuchi, H., Honda, T., Yamada, S., Nakayama, T., Fujita, J., Maeda, M., Tachibana, T., Suginami. H., and Mori, T. (1998) Bestatin, an aminopeptidase inhibitor, promotes follicular growth and ovulation suppressed by stress in mice. Endocrine. Journal., 45, 547-553.

Fujita, K., Nakamura, T., Takabatake, K., Higuchi, H., Fujita, J., Maeda, M., Fujiwara, H., and Mori, T. (1998) Administration of thymocytes derived from non-pregnant mice induces an endometrial receptive stage and leukemia inhibitory factor expression in the uterus. Hum. Reprod., 10 , 2888-2894.

 

心臓血管外科学分野 (Cardiovascular Surgery)

Nishimura, N., Kono, S., Nishina, T.,Akamatsu, T., Tsukiya, T., Nojiri, C., Ozaki, T., Komeda, M. Results of Chronic animal experiments with a new version of a magnetically suspended centrifugal pump. ASAIO-J, 44(5), M725-7.

Fujioka, Y., Matsuoka, S., Ban, T., Noma, A. Interaction of the Na+-K+ pump and Na+-Ca2+ exchange via [Na+]i in a restricted. J-Physiol-Lond,509(pt2),457-70.

Nishimura, K., Yamada, T., Kono,S., Yuasa, S., Tukiya, T., Akamatsu, T., Nakazeki, T., Ozaki,T., Ban,T. Magnetically suspended centrifugal pump as an Implantable assist system. Heart Replacement- Artificial Heart 6 eds,391-395.

西村和修、河野智、仁科健、松田捷彦、築谷朋典、野尻知里、木島利彦 磁気浮上型遠心ポンプの慢性動物実験成績 - 体外設置型から植え込み型へ - 人工臓器,27,313-318

岩倉篤、米田正始、藤田正俊 冠狭窄と血管新生機構 日本臨床,56(10),46-50

Mizuhara, H ., Koshiji, T., Nishimura, K., Nomoto, S., Matsuda, K., Ban, T. Evalustiion of a compressive-type skeletal muscle pump for cardiac assistance. Ann-Thorac-Surg,67(1),105-11

河野智、西村和修、仁科健、大野暢久、米田正始、赤松映明 遠心ポンプによる左室脱血左心補助の有用性(左房脱血との比較) 人工臓器 28,416-42

 

筋・骨格系病態分野(Orthopaedic and Musculoskeletal surgery)

M.Kobayashi, T.Nakamura, T.Kikutani, K.Kawanabe, T,Kokubo; Effect of Polymerization Reaction Inhabitor on Mechanical Properties and Surface Reactivity of Bioactive Bone Cement; Journal of BIOMEDICAL MATERIALS RESEARCH APPLIED BIOMATERIALS;43;2;140-152;1998

M.Kobayashi, T.Nakamura, Y.Okada, A.Fukumoto, T.Furukawa, H.Kato, T.Kokubo, T.Kikutani ;Bioactive bone cement:Comparison of apatite and wollastonite containing glass-ceramic, hydroxyapatite, and ァ -Tricalcium phosphate fillers on bone-bonding strength: J.Biomed Mater Res:42:223-237:1998

Wei-Qi Yan, M.Oka, T.Nakamura ; Bone bonding in bioactive glass ceramics combined with bone matrx gelatin.; Journal Of Biomedical Materials Reserch;42;2;258-265;1998

H.Matsuoka, T.Nakamura, H.Takadama, S.Yamada, J.Tamura, Y.Okada, M.Oka, T.Kokubo; Osteoclastic resorption of bone-like apatite formed on a plastic disk as an in vitro assay system.; Journal Of Biomedical Materials Reserch;42;2;278-285;1998

Y.Okada, M.Kobayashi, H.Fujita, Y.Katsura, H.Takadama, T.Kokubo, T.Nakamura ; A comparative study of ultrastructures of bioactive bone cement and bone.; Bioceramics; 11;451-454;1998

S.Shinzato, M.Kobayash, H.Fujita, K.Choju, T.Kokubo, T.Nakamura; Bone-bonding strength of Alumina bead composite.; Bioceramic;11;391-394;1998

S.Nishiguchi, T.Nakamura, H.Kato, H.Fujita, Hyun-Min Kim, F.Miyaji,T.Kokubo; Enhancement of bone bonding strength of titanium alliys by alkali and heat treatmenrs.;Bioceramics;11;675-678;1998

T.Furukawa, Y.Matsusue, T.Yasunaga, M.Kobayash, H.Fujita, Y.Shikinami, M.Okuno, T.Nakamura; Ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures:In vivo study.; Bioceramics;11;419-422;1998

H.Kato, T.Nakamura, S.Nishiguchi, H.Fujita, T.Miyazaki. F.Miyaji, Hyun-Min Kim, T.Kokubo; The effect of alkali and heat treatment on bone bonding ability of tantalum.;Bioceramics;11;671-674;1998

T.Yamamuro, T.Nakamura, H.Iida, K.Kawanabe, Y.Matsuda, K.Ido, J.Tamura, Y.Senaha; Development of bioactive bone cement and its clinical applications.;Biomaterials;19;1497-1482;1998

M.Kobayashi, T.Nakamura, Y.Okada, S.Shinzato, T.Kokubo, T.Kikutani; Bioactive composite:Comparison of ceramic fillers on osteoconductivity and bone-bonding strength;Bioceramics;11;371-374;1998

H.Fujita, K.Ido, Y.Matsuda ,H.Iida ,M.Oka, T.Nakamura; Porous AW Glass Ceramic as a Femoral Intramedullary Plug.; Bioceramics;11;645-648;1998

T.Yasunaga, Y.Matsusue, T.Furukawa, Y.Shikinami, M.Okuno, T.Nakamura; Bonding Behavior of Ultrahigh Strength Unsintered Hydroxyapatite Particles/Poly(l-lactide) Composites to Surface of Tibial Cortex in Rabbits;JBMR;47;3;412-419;1998

中村孝志、バイオマテリアルと生体-副作用と安全性、整形外科用材料、164-176;1998

藤田裕、中村孝志、生体材料としての人工関節、Pharma Medica、16;12;23-30;1998

川那辺圭一、飯田寛和、松末吉隆、西松秀和、中村孝志、人工股関節の素材、整形・災害外科、41; 693-698;1998

新里修一、小林雅彦、藤田裕、小久保正、長寿研、中村孝志、Alumina Bead Compositeの骨結合能; Orthopaedic Ceramic Implants;18;1-4;1998

M.Kobayashi, T.Nakamura, J.Tamura, T.Kikutani, S.Nishiguchi, W.F.Mousa, M.Takahashi, T.Kokubo; Osteoconductivity and Bone-bonding strength of high-and low-viscous bioactive bone cements.;48;265-276;1999

Y.Okada, T.Nakamura; Transmission electron microscopic study of the interface between bioactive bone cement and bone: comparison of AW-GC filler withhydroxyapatite and β-TCP fillers.; J.Biomed Mater Res;45;277-284;1999

N.Ikeda; Quantitative comparison of osteconduction of porous dense, A-W glass ceramic and hydroxyapatite granules.;Biomaterials;20;1087-1095;1999

S.Shinzato, M.Kobayashi, K.Choju, T.Kokubo, T.Nakamura; Bone-bonding behavior of alumina bead composite.; J.Biomed Mater Res;46;287-300;1999

K.Ohura, C.Hamanishi, S.Tanaka, N.Matsuda; Healing of segmental bone defects in rats induced by a β-TCP-MCPM cement combined with rh BMP-2;J.Biomed.Mater Res;44;168-175;1999

H Fujita, H.Iida, K.Kawanabe, Y.Okada, M.Oka, T.Matsuda, Y.Kitamura, T.Nakamura; Pressurization of Bioctive Bone Cement In Vitro; Journal of Biomaterials Research.Applied Biomaterials;48;1;43-51;1999

H.Fujita.,H.Iida.,K.Kawanabe.,Y,Okada.,M.Oka.,T.Masuda.,Y.Kitamura.,T.Nakamura; Pressurization of Bioactive Bone Cement In Vivo; J.Biomed Mater Res;48;43-51;1999

S.Nishiguchi, T.Nakamura, M.Kobayashi, Hyun-Min Kim, F.Miyaji, T.Kokubo;The effect of heat treatment on bone-bonding ability of alkali-treated titanium;Biomaterials;20;491-500;1999

T.Nakamura, S.Nishiguchi, Hyun-Min Kim, F.Miyaji, T.Kokubo;Bioactive Titanium and its alloys;Materials in clinical applications;28;289-300;1999

M.Kobayashi, Y.Okada, W-F Mousa, S.Shinzato, T.Kokubo, T.Kikutani, I.Kono, T.Nakamura; BASIC PROPERTIES OF BIOACTIVE CEMENT FOR PROSTHESIS FIXATION;SIROT;72-77;1999

S.Yura, M.Oka, K.Ushio, H.Fujita, T.Nakamura; Development of artificial interverteral disk using polyvinyl alcohol hydrogels.;SIROT;371-376;1999

Y.Okada, M.Kobayashi, H.Fujita, Y.Katsura, H.Matsuoka, H.Takadama, T.Kokubo, T.Nakamura; Transimission electron microscopic study of interface between bioactive bone cement and bone:comparison of apatite and wollastonite containing glass-ceramic filler with hydroxyapatite and β-Tricalcium phosphate fillers.;J.Biomed Mater Res;45;277-284;1999

W.F.Mousa, H.Fujita, K.Ido, M.Neo, M.Kobayashi, I.A.Zeinedin, M.Matsushita, T.Nakamura; Bone-Bonding Ability of Bioactive Bone cement under Mechanical Stress; JBMR,Appl Biomater; 48;689-696;1999

S.Nishiguchi, H.Kato, H.Fujita, Hyun-Min.Kim, F.Miyaji, T.Kokubo, T.Nakamura; Enhancement of Bone-Bonding Strengths of Titanum Alloy Implants by Alkali and Heat Treatments.; JBMR APPLIED BIOMATERIALS;48;5;689-696;1999

J.Kawai, H.Akiyama, C.Shigeno, H.Ito, J.Konishi, T.Nakamura; Effects of transforming growth factor- β signaling on chondrogenesis in mouse chondrogenic EC cells,ATDC5; Euorpean Journal of cell biology; 78;707-714;1999

M.Kobayashi, T.Nakamura, S.Shinzato, W.F.Mousa, K.Nishio, K.Osawa,T.Kokubo, T.Kikutani; Effect of bioactive filler content on mechanical properties and osteocondactivity of bioactive bone cement.;J.Biomed Mater Res;46;447-457;1999

M.Matsuoka, H.Akiyama, Y.Okada, H.Ito, C.Shigeno, J.Konishi, T.Kokubo, T.Nakamura; In Vitro analysis of the stimulation of bone formation by highly bioactive apatite-and wollastonite-containing galss-ceramic:Released calcium ions promote osteogenic differentitation in osteoblastic ROS 17/2.8cells; JBMR; 47;176-188;1999

W.F.Mousa, M.Kobayashi, Y.Kitamura, I.A.Zeineldin, T.Nakamura ;Effect ofSilane Treatment and Different Resin Compositions on Biological Properties of Bioactive Bone CementContaining Apaptite-Wollastonite Glass Ceramic Powder; JBMR;47;3;336-344;1999

Y.Okada, K.Kawanabe, H.Fujita, K.Nishio, T.Nakamura ; Repair of Segmental Bone Defects Using Bioactive Bone Cement: Comparison with PMMA Bone Cement;JBMR;47;3;353-359;1999

M.Oka, K.Ushio, S.Yura, H.Fujita, T.Nakamura; CHANGES OF JOINT SURFACES OPPOSING AGAINST VARIOUS BIOMATERIALS;Bioceramics;12;91-94;1999

S.Shinzato, M.Kobayashi, W.F.Mousa, M.Kobayashi, W.F.Mousa, M.Kamimura, M.Neo, K.Choju, T.Kokubo, T.Nakamura; EFFECTS OF SURFACE CURING PROPERTIES ON BONE-BONDINGSTRENGTH OF BIOACTIVE BONE CEMENT;Bioceramics;12;513-516;1999

M.Kobayashi, T.Nakamura, Y.Okada, W.F.Mousa, S.Shinzato, T.Kokubo, T.Kikutani; BIOACTIVE COMPOSITE:EFFECT OF CERAMIC FILLER CONTENTON MECHANICAL PROPERTY AND OSTEO-CONDUCTIVITY; Bioceramics;12;417-420;1999

H.Fujita, K.Ido, W.F.Mousa, K.Ushio, H,Iida, K.Kawanabe, S.Yura, M.Oka, T.Nakamura; Femoral bone resorption observed in canine THA usuing bioactive bone cement.;Bioceramics;12;517-520;1999

S.Nishiguchi, H.Kato, H.Fujita, Hyun-Min Kim, F.Miyaji, T.Kokubo, T.Nakamura; Enhancement of Bone-Bonding Strengths of Titanium Alloy Implants by Alkali and Heat Treatments.;J.Biomed Mater Res(Appl Biomater);48;689-696;1999

T.Nakamura, S.Nishiguchi; Tensile testing of bone-implant interface.; Mechanical Testing of Bone and the Bone-Implant Interface;489-497;1999

中村孝志、整形外科におけるセラミックス人工骨-臨床の現状と課題、セラミックス、34;7; 529-533;1999

岡正典、由良茂人、玄丞烋、中村孝志、人工椎間板の開発、脊椎脊髄ジャーナル、12;6;429-434; 1999

中村孝志、21世紀の整形外科、人工体内材料の占める位置、整形・災害外科;42;12;1999

牛尾一康、中村孝志、岡正典、玄丞烋、速水尚、由良茂人、森川将名、ポリビニールアルコール・ハイドロゲルの生体内安定性評価、日本臨床バイオメカニクス学会誌、20;315-318;1999

 

視覚病態学分野 (Ophthalmology and Visual Science)

Suzuma K, Takagi H, Otani A, Oh H, Honda Y :Expression of thrombospondin-1 in ischemia-induced retinal neovascularization. Am J Pathol 1999 154 : 343-354.

Oh H, Takagi H, Suzuma K, Otani A, Matsumura M, Honda Y : Hypoxia and vascular endothelial growth factor selectively up-regulateangiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 1999 274 : 15732-15739.

Miyamoto N, Mandai M, Suzuma I, Suzuma K, Kobayashi K, Honda Y : Estrogen protects against cellular infiltration by reducing the expressionsof E-Selectin and IL-6 in endotoxin-induced uveitis. J Immunology 1999 163:374-379.

 

口腔機能病態学 (Oral and Maxillofacial Surgery)

小西康三、別所和久、藤村和磨、大久保康則、楠本健司、飯塚忠彦 (1998). コラーゲンを担体とした遺伝子組み換えヒト骨形成因子による骨誘導に関する研究. 日本口腔外科学会雑誌、44、951-955.

Yoshida, K., Kazuhisa Bessho, K., Fujimura, K., Kusumoto, K., Ogawa, Y., Tani, Y., and Iizuka, T. (1998). Osteoinduction Capability by Recombinant Human Bone Morphogenetic Protein-2 in Intramuscular and Subcutaneous Sites: an Experimental Study. Journal of Cranio-Maxillofacial Surgery, 26, 112-115.

Kusumoto, K., Bessho, K., Fujimura, K., Akioka, J., Ogawa, Y., and Iizuka, T. (1998). Prefabricated Muscle Flap Including Bone Induced by Recombinant Human BMP-2; An Experimental Study of Ectopic Osteoinduction in a Rat Latissimus Dorsi Muscle Flap. British Journal of Plastic Surgery, 51, 275-280.

大久保 康則、別所和久、高 済石、金田典子、堀 信介、飯塚忠彦 (1999). 解急蜀椒湯(TJ-022)の鎮痛作用に関する実験的検討.日本口腔外科学会雑誌、45、116-118.

Bessho, K., Kusumoto, K., Fujimura, K., Konishi, Y., Ogawa, Y., Tani, Y., and Iizuka, T. (1999). Comparison of Recombinant and Purified Human Bone Morphogenetic Protein. British Journal of Oral and Maxillofacial Surgery, 37, 2-5.

Okubo, Y., Bessho, K., Fujimura, K., Kusumoto, K., Ogawa, Y., Tani, Y., and Iizuka, T. (1999). Comparative Study of Intramuscular and Intraskeletal Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 87, 34-38.

Yoshida, K., Bessho, K., Fujimura, K., Konishi, Y., Kusumoto, K., Ogawa, Y., and Iizuka, T. (1999). Enhancement by Recombinant Human Bone Morphogenetic Protein-2 of Bone Formation Using Porous Hydroxyapatite in Mandibular Bony Defects. Journal of Dental Research, 78, 1505-1510.

 

形成外科学分野 (Plastic and Reconstructive Surgery)

Yoshihisa Suzuki , Masao Tanihara , Katsunori Ohnishi , Kyoko Suzuki ,Katsuaki Endo, Yoshihiko Nishimura1999. Cat peripheral nerve regeneration across 50 mm gap repaired with a novel nerve guide composed of freeze-dried alginate gel. Neurosci. Letters.,259,75-78

 

腫瘍外科学分野 (Surgery and Surgical Basic Science)

Niwano M, Arii S, Mori A, Ishigami S, Harada T, Mise M, Furutani M, Fujioka M, Imamura M. (1998). Inhibition of tumor growth and microvascular angiogenesis by the potent angiogenesis inhibitor, TNP-470, in rats. Surg Today, 28, 915-22.

Nakamura T, Arii S, Monden K, Furutani M, Takeda Y, Imamura M, Tominaga M, Okada Y. (1998). Expression of the Na+/Ca2+ exchanger emerges in hepatic stellate cells after activation in association with liver fibrosis. Proc Natl Acad Sci U S A 95, 5389-94

Yamasaki S., Kanaoka S., Inoue N., Okino T., Kan N., Shimada Y., Imamura M.(1998) "Possibility of in vivo therapy using tumor-antigen-derived peptide" in Japanese. Biotherapy 12(5):569-571

Yamasaki S., Kanaoka S., Inoue N., Okino T., Shimada Y., Imamura M. (1998) "Expression of Fas ligand in human esophageal cancer cell lines: Interaction with activated lymphocytes" Proc Am Assoc Cancer Res 39:583-583

Li L., Okino T., Kan N., Yamasaki S., Ichinose Y., Sugie T., Kanaoka S., Imamura M. (1998) "Analysis of effector cells in tumor-bearing mice pre-treated with active specific immunization followed by cyclophosphamide" Biotherapy 11:223-228

Kanaoka S., Yamasaki S., Inoue N., Imamura M. (1998) "Induction of anti-tumor immunity using peptide-binding dendritic cells" in Japanese. Clin Immunol 30(8):1050-1057

Li L., Okino T., Sugie T., Yamasaki S., Ichinose Y., Kanaoka S., Kan N., Imamura M. (1998) "Cyclophosphamide given after active specific immunization augments antitumor immunity by modulation of Th1 commitment of CD4+ T cells" J Surg Oncol 67:221-227

Kaido T, Seto S, Imamura M, et al. (1998) Perioperative continuous HGF supply from spleen effectively prevents liver failure following resection of cirrhotic liver. J. Surg. Res. 74, 173-178.

Kaido T, Yoshikawa A, Seto S, et al. (1998) Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic rats. Hepatology 28, 756-760.

Yoshikawa A, Kaido T, Seto S, et al. (1998) Hepatocyte growth factor promotes liver regeneration with prompt improvement of hyperbilirubinemia in hepatectomized cholestatic rats. J. Surg. Res. 78, 54-59.

Seto S, Kaido T, Imamura M, et al. (1998) Hepatocyte growth factor prevents LPS-induced hepatic sinusoidal endothelial cell injury and microvascular fibrin deposition in rats. J. Surg. Res. 80, 194-199.

Inoue N., Kanaoka S., Yamasaki S., Arii S., Imamura M. (1999) "Production of specific antibody and T helper 1-dominant cytokine elicited by dendritic cells genetically modified with an adenovirus vector" Immunol Letters 70:77-81

Kanaoka S., Yamasaki S., Okino T., Inoue N., Shimada Y., Kaneko M., Otaka A., Fujii N., Imamura M. (1999) "Induction of human leukocyte antigen (HLA)-A2-restricted and MAGE-3-gene-derived peptide-specific cytotoxic T lymphocytes using cultured dendritic cells from a HLA-A2 esophageal cancer patient" J Surg Oncol 71:16-21

Arii S, Mori A, Uchida S, Fujimoto K, Shimada Y, Imamura M. (1999). Implication of vascular endothelial growth factor in the development and metastasis of human cancers. Hum Cell 12, 25-30

Takeda Y, Arii S, Kaido T, Niwano M, Moriga T, Mori A, Hanaki K, Gorrin-Rivas MJ, Ishii T, Sato M, Imamura M. (1999). Morphologic alteration of hepatocytes and sinusoidal endothelial cells in rat fatty liver during cold preservation and the protective effect of hepatocyte growth factor. Transplantation 67, 820-8.

Mori A, Arii S, Furutani M, Hanaki K, Takeda Y, Moriga T, Kondo Y, Gorrin Rivas MJ, Imamura M (1999). Vascular endothelial growth factor-induced tumor angiogenesis and tumorigenicity in relation to metastasis in a HT1080 human fibrosarcoma cell model. Int J Cancer, 80, 738-43

Kaido T, Yoshikawa A, Seto S, et al. (1999) Hepatocyte growth factor supply accelerates compensatory hypertrophy caused by portal branch ligation in normal and jaundiced rats. J. Surg. Res. 85, 115-119.

Kaido T, Yoshikawa A, Seto S, et al. (1999) Thrombomodulin prevents intrasinusoidal coagulation and liver dysfunction following extensive hepatectomy in cirrhotic rats. Thromb. Haemost. 82, 1302-1306.

Kato M, Shimada Y, Tanaka H, Hosotani R, Ohshio G, Ishizaki K, Imamura M (1999) Characterization of six cell lines established from human pancreatic adenocarcinomas. Cancer 85:832-840

 

附属動物実験施設(Institute of Laboratory Animals)

Serikawa, T., and van Zutphen, L.F.M.(1999). Report on rat chromosome 3. J. Exp. Anim. Sci., 40, 27-35.

Serikawa, T. (1999). Comparative genome map and positional cloning. Appl. Biol. Sci., 5 (1), 73.

Nakane, Y., Voigt, B., Kitada, K., and Serikawa, T. (1999). Evaluation of up-dated rat-mouse-human comparative map. Rat Genome, 5, 48-60.

Yokoi, N, Kondo, Y., Maihara, T., Kuramoto, T., Cui, Z., Nakane, Y., Voigt, B., Kitada, K., and Serikawa, T. (1999). Screening of mouse SSLP markers applicable to rat genetic studies. Rat Genome, 5, 61-67.

Sato, H, Iizuka, T., Koike, R., Miyasaka, N., Kitada, K., Kuramoto, T., Serikawa, T., and Watanabe, T. (1999). Assignment of the Madcam1 gene to rat chromosome 7q11.2 - q12 by fluorescence in situ hybridization, somatic cell hybrids and linkage analysis. Cytogenet. Cell Genet., 86, 223-224.

Sejima, H., Ito, M., Kishi, K., Noda, A., and Serikawa, T. (1999). Regional excitatory and inhibitory amino acid concentrations in Noda epileptic rat (NER) brain. Brain Develop, 21,382-385.

Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T., and Honjo, T. (1999). Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kB-inducing kinase. Nature Genet, 22, 74-77.

Serikawa, T., Kuramoto, T., Yokoi, N., Andoh, Y., Cui, Z., Kondo, Y., and Kitada, K. (1999). Rat genetic map and a rat/mouse/human comparative gene map.Transplant. Proc., 31, 1537-1540.

Shimizu, M., Higuchi, K., Bennett, B., Xia, C., Tsuboyama, T., Kasai, S., Chiba, T., Fujisawa, H., Kogishi, K., Kitado, H., Kimoto, M., Takeda, N., Matsushita, M., Okumura, H., Serikawa, T., Nakamura, T., Johnson, T. E., and Hosokawa, M. (1999). Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm. Genome, 10, 81-87.

Oyabu, A., Higo, K., Ye, C., Amo, H., Saito, M., Yagyu, S., Morita, H., Maeda, K., Serikawa, T., Takahashi, M., and Matsuyama, M. (1999). Genetic mapping of the thymoma susceptible locus, Tsr1, in BUF/Mna rats. J. Natl. Cancer Inst., 91 (3), 279-282.

Noda, A., Hashizume, R., Maihara, T., Tomizawa, Y., Ito, Y., Inoue, M., Kobayashi, K., Asano, Y., Sasa, M., and Serikawa, T. (1998). NER rat strain, a new type of genetic model in epilepsy research. Epilepsia, 39 (1), 99-107.

Serikawa, T., Cui, Z., Yokoi, N., Kuramoto, T., Kondo, Y., Kitada, K., and Gu始et,, J.-L. (1998). A comparative genetic map of rat, mouse and human genomes. (1998). Exp. Anim., 47 (1), 1-9.

Andoh, Y., Kuramoto, T., Yokoi, N., Maihara, T., Kitada, K., and Serikawa, T. (1998). Correlation between genetic and cytogenetic maps of the rat. Mamm Genome, 9 (4), 287-293.

Kuramoto, T., Yamasaki, K., Kondo, A., Nakajima, K., Yamada, M., and Serikawa, T. (1998). Production of WTC.ZI-zi rat congenic strain and its pathological and genetic analyses. Exp. Anim., 47 (2), 75-81.

Cui, Z., Yokoi, N., Kuramoto, T., Kitada, K., and Serikawa, T. (1998). Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes. Exp. Anim., 47 (2), 83-88.

Iida, K., Sasa, M., Serikawa, T., Noda, A., Ishihara, K., Akimitsu, T., Hanaya, R., Arita, K., and Kurisu, K. (1998). Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER). Epilepsy Res., 30, 115-126.

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