Update:April/15/2002
ExHC (Exogenously Hypercholesterolemic rat)
執筆者：佐藤 匡央（九州大学大学院農学研究院生物機能科学部門生物機能栄養化学研究室)
食事性高コレステロール血症
今井らは雄Sprague-Dawleyラット（SD/Jcl）から、1%コレステロール、0.2％コール酸ナトリウムおよび5％オリーブ油を加えた飼料を7日間与えると 約250mg/dl程度の高コレステロール血症を呈するラットを単離した。（SDラットは同様な食事で約100mg/dl前後）
3. 表現型・病態
先に述べたように、食事性高コレステロール血症を呈する。
5. 臨床への応用性、有用性
食事コレステロールに応答して血清コレステロール濃度が上昇するので、食品としてのコレステロール摂取における他の食事成分の影響が、高感度で検出できる。
7. 文献
Imai Y. Matsumura H.
Genetic studies on induced and spontaneous
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M. Sato, S. Yoshida, K. Nagao, & K.
Imaizumi
Superiority of dietary safflower oil over olive oil in lowering serum
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Ethanol-extracted soy protein isolate results in elevation of serum cholesterol
in exogenously hypercholesterolemic rats.
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Exogenously hypercholesterolemic rats, compared with their progenitor
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M.Sakono, H.Mori, K.Nagao, M Sato,
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ExHC (exogenous hypercholesterolemic) rats, compared with their progenitor,
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Comp.
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K.Imaizumi, A.Nagatomi, M.Sato,
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Cholesterol metabolism in ExHC (exogenous hypercholesterolemic) rats.
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