| NBRP Rat No: 0661 |
Strain name: A5M/Khos |
Commmon Name: AQP5変異ラット（AQP5-mutant rat） |
Rat Genome Database |
| Principal Investigator: |
Kazuo Hosoi University of Tokushima Graduate School 3-18-15 Kuramoto-Cho 770-8504 Tokushima-shi Japan |
| Tel: 088-633-7323 Fax: 088-633-7324 |
Email: khosoi@tokushima-u.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
白 |
| Inbred Generations |
F36（H24年1月20日現在） |
| Usage Restrictions |
In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Murdiastuti,K., N.N.Purwanti, M.R.Karabasil, X.Li, C.Yao, T.Akamatsu, N.Kanamori, and K.Hosoi, "A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands", American Journal of Physiology-Gastrointestinal and Liverand Liver Physiology, 291(6), G1081-G1088, 2006, December. |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
ラット aquaporin 5 |
| Origin |
This mutant strain was detected by the existence of a point mutation at 308 (G308A) in the aquaporin 5 (AQP5) gene in Sprague-Dawley rat colony.
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| Strain characteristics |
The rats having this mutation show extremely low membrane expression of AQP5 in the SMG acinar cells and decreased water secretion from their salivary glands.
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| Breeding Conditions |
Sib mating
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| Genotyping |
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| References |
Karabasil, M.R., T. Hasegawa, A. Azlina, N. Purwanti, C. Yao, T. Akamatsu, S. Tomioka, and K. Hosoi, "Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking, and cellular localization in the submandibular gland of rats," Biology of the Cell, 103(2), 69-86, 2011
Beitz, E. edition, “Aquaporins” in Handbook of Experimental Pharmacology, 190, (Editor in Chief, F. Hofmann), Springer-Verlag, Berlin, 2009
Murdiastuti,K., N.Purwanti, M.R.Karabasil, X.Li, C.Yao, T.Akamatsu, N.Kanamori, and K.Hosoi, "A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands", American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(6), G1081-G1088, 2006
Murdiastuti,K., O.Miki, C.Yao, M.N. Parvin, C.Kosugi-Tanaka, T.Akamatsu, N.Kanamori, and K.Hosoi, "Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats", Pflugers Archives- European Journal of Physiology, 445(3), 405-412, 2002
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| Additional strain information |
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