The National BioResource Project for the Rat in Japan

Strain information

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NBRP Rat No: 0694
Strain name: F344-Il2rgem7Kyo
Commmon Name: XSCID-TALEN
Rat Genome Database
Principal Investigator:
Tomoji Mashimo The University of Tokyo, The Institute of Medical Science
Preservation Status:
Coat Color
albino (c)
Inbred Generations
G1
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Comercial Availability
Research Category
Gene Affected
interleukin 2 receptor gamma (Il2rg)
Origin
The strain having a Endonuclease-induced mutation in Il2rg gene was established by TAL effector nuclease obtained from Dr. Yamamoto at Hiroshima University.
Strain characteristics
This strain shows severe combined immunodeficiency caused by a 7-bp deletion in the exon 2 of Il2rg gene.
Breeding Conditions
Genotyping
References
Tanaka M.
Rat polyomavirus 2 infection - secondary publication.
Exp Anim. 2025 Sep 3.

Mizuno-Iijima S, Kawamoto S, Asano M, Mashimo T, Wakana S, Nakamura K, Nishijima KI, Okamoto H, Saito K, Yoshina S, Miwa Y, Nakamura Y, Ohkuma M, Yoshiki A.
Mammalian genome research resources available from the National BioResource Project in Japan.
Mamm Genome. 2024 Dec;35(4):497-523.

Tadokoro T, Murata S, Kato M, Ueno Y, Tsuchida T, Okumura A, Kuse Y, Konno T, Uchida Y, Yamakawa Y, Zushi M, Yajima M, Kobayashi T, Hasegawa S, Kawakatsu-Hatada Y, Hayashi Y, Osakabe S, Maeda T, Kimura K, Mori A, Tanaka M, Kamishibahara Y, Matsuo M, Nie YZ, Okamoto S, Oba T, Tanimizu N, Taniguchi H.
Human iPSC-liver organoid transplantation reduces fibrosis through immunomodulation.
Sci Transl Med. 2024 Jul 24;16(757):eadg0338.

Shinji Kawaguchi, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Shugo Tohyama, Ryota Tabei, Akinori Hirano, Noriko Handa, Yoshitake Yamada, Shigeo Okuda, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Yoshikazu Kishino, Marina Okada, Sho Tanosaki, Shota Someya, Yuika Morita, Hidenori Tani, Yujiro Kawai, Masataka Yamazaki, Akira Ito, Rei Shibata, Toyoaki Murohara, Yasuhiko Tabata, Eiji Kobayashi, Hideyuki Shimizu, Keiichi Fukuda, Jun Fujita
Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals
JACC Basic Transl Sci. 2021 Feb 19;6(3):239-254.

Tsuchida T, Murata S, Matsuki K, Mori A, Matsuo M, Mikami S, Okamoto S, Ueno Y, Tadokoro T, Zheng YW, Taniguchi H.
The Regenerative Effect of Portal Vein Injection of Liver Organoids by Retrorsine/Partial Hepatectomy in Rats
Int J Mol Sci. 2019 Dec 26;21(1):178. doi: 10.3390/ijms21010178.

Tanaka M, Kuramochi M, Nakanishi S, Kuwamura M, Kuramoto T.
Rat polyomavirus 2 infection in a colony of X-linked severe combined immunodeficiency rats in Japan.
J Vet Med Sci. 2018 Sep 13;80(9):1400-1406.

Matsuoka AJ, Sayed ZA, Stephanopoulos N, Berns EJ, Wadhwani AR, Morrissey ZD, Chadly DM, Kobayashi S, Edelbrock AN, Mashimo T, Miller CA, McGuire TL, Stupp SI, Kessler JA.
Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles.
PLoS One. 2017 Dec 28;12(12):e0190150.

Rigatti LH, Toptan T, Newsome JT, Moore PS, Chang Y.
Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay.
mSphere. 2016 Dec 21;1(6). pii: e00334-16.

Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T.
Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.
Sci Rep. 2013 Nov 29;3:3379.
Additional strain information (Japanese only)