NBRP Rat No: 0016 |
Strain name: TRMR/Kyo |
Commmon Name: TRMR, TRM/Tan, Tremor Resistant |
Rat Genome Database |
Principal Investigator: |
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN |
Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
F40+42 (March 2012) |
Usage Restrictions |
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Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
Aspa: aspartoacylase |
Origin |
Tremor Rat which was found in a colony of outbred Wistar/Kyo in 1980 was separated to Tanabe Seiyaku Co., Ltd. in 1982.
This strain is a substrain of TRM/Kyo and does not show tremor behavior. |
Strain characteristics |
vacuole formation. Segregating inbred strain. No tremor behavior. |
Breeding Conditions |
Homozygous infertility. Maintained in heterozygous condition. |
Genotyping |
Genomic deletion of Aspa gene is detected by PCR.
Genotyping protocol for tm |
References |
Yamada J, Serikawa T, Ishiko J, Inui T, Takada H, Kawai Y and Okaniwa A.
Rats with congenital tremor and curled whiskers and hair.
Jikken Dobutsu, 34: 183-188, 1985.
Serikawa T, Ohno Y, Sasa M, Yamada J and Takaori S.
A new model of petit mal epilepsy: spontaneous spike and wave discharges in tremor rats.
Lab Anim, 21: 68-71, 1987.
Kitada K, Akimitsu T, Shigematsu Y, Kondo A, Maihara T, Yokoi N, Kuramoto T, Sasa M and Serikawa T.
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
J Neurochem, 74: 2512-2519, 2000.
Ohno Y, Shimizu S, Tatara A, Imaoku T, Ishii T, Sasa M, Serikawa T, Kuramoto T.
Hcn1 is a tremorgenic genetic component in a rat model of essential tremor.
PLoS One. 2015 May 13;10(5):e0123529. |
Additional strain information |
TRM |
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