Strain information
 NBRP Rat No: 0099  Strain name: ACI.BUF-(D15Rat97-D15Rat29)/Ncc  Commmon Name: ACI.BUF-Gcs1/Ncc, ACI.BUF-Gcs1 Rat Genome Database
Principal Investigator:  Toshikazu Ushijima  National Cancer center       5-1-1 Tsukiji, Chuo-ku    104-0045 Tokyo     JAPAN
Tel: 03-3547-5240    Fax: 03-5565-1753 Email: tushijim@ncc.go.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  A,B,C,H
Inbred Generations  N5F10
Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin This congenic strain is homozygous for the BUF/Nac Gcs1 allele (on chr.15) on the ACI/N background.
ACI/N rats are susceptible and BUF/Nac rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. By using ACI x (ACIxBUF) F1 backcross rats, one dominant susceptibility gene, Gcs1 (Gastric cancer susceptibility gene 1), and three dominant resistance genes, Gcr1 (Gastric cancer resistance gene 1), Gcr2 and Gcr3 have been mapped on chromosome 15, 4, 3 and 16 respectively by QTL analysis for MNNG-induced stomach carcinogenicity (Ushijima, 2000). (Feb 4, 2008)
Strain characteristics
Breeding Conditions Good breeding performance.
Genotyping D15Rat97, D15Rat29
References Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M.
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer Res, 60:1092-1096, 2000
Additional strain information ACI BUF