Strain information
 NBRP Rat No: 0148  Strain name: Gunn-Ugt1a1j/Slc  Commmon Name: Gunn/Slc-j/j, Gunn's (Nonhemolytic jaundiced rat) Rat Genome Database
Principal Investigator:  Sadaaki Takagi  Japan SLC, Inc       3371-8, Kotoh-cho, Hamamatsu    431-1103 Shizuoka     Japan
Tel: 053-486-3178    Fax: 053-486-3156 Email: slc01@jslc.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/Gunn%20Slc-j%20j/711a%20(Large).jpg ../images/Photos/Gunn%20Slc-j%20j/711z%20(Large).jpg
Coat Color  black hooded
Inbred Generations  F32+54
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability Japan SLC, Inc
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Ugt1a1: UDP glycosyltransferase 1 family, polypeptide A1
Origin Originated from mutant rat found in Wistar rat.
Strain characteristics The Gunn rat is a mutant strain of Wistar rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin. Caused by a single guanosine (G) base deletion within the UGT1A1 gene. Animal model of Crigler–Najjar syndrome type I. (Mar 2008)
Breeding Conditions Sib mating. Heterozygous female and homozygous male are mated. Poor breeding performance.
Genotyping
References Iyanagi T, Watanabe T, Uchiyama Y.
The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation.
J Biol Chem. 1989 Dec 15;264(35):21302-7.
Additional strain information Gunn