NBRP Rat No: 0148
Commmon Name: Gunn/Slc-j/j, Gunn's (Nonhemolytic jaundiced rat)
Rat Genome Database
Sadaaki Takagi Japan SLC, Inc 3371-8, Kotoh-cho, Hamamatsu 431-1103 Shizuoka Japan
Tel: 053-486-3178 Fax: 053-486-3156
Japan SLC, Inc
Research Area Others
Ugt1a1: UDP glycosyltransferase 1 family, polypeptide A1
Originated from mutant rat found in Wistar rat.
The Gunn rat is a mutant strain of Wistar rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin. Caused by a single guanosine (G) base deletion within the UGT1A1 gene. Animal model of Crigler–Najjar syndrome type I. (Mar 2008)
Sib mating. Heterozygous female and homozygous male are mated. Poor breeding performance.
Iyanagi T, Watanabe T, Uchiyama Y.
The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation.
J Biol Chem. 1989 Dec 15;264(35):21302-7.
Additional strain information