Japanese
 NBRP Rat No: 0014 Strain Name: TM/Kyo Commmon Name: tester Moriyama rat
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F20+102 (March 2012) 
   
 Coat Color
 Deposition Status
 
 fawn hooded (a,B,C,h,P,r)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Rab38: Rab38, member of RAS oncogene family. ruby or red eyed dilution
 Origin Tester Moriyama rat derived from Long-Evans at Aichi Cancer Center, were transferred to Moriyama Mental Disease Hospital and Nagoya University. Inbred Line was established at Nagoya University. From Shionogi & Co., Ltd. to Kyo in 1976 . 
 Strain Characteristics Used as caot color tester line modified blood caogulation and platelet derived serotonin release was detected. Used as an animal model for platelet storage pool deficiency. TM has a Met1Ile mutation at the translation initiation codon of the Rab38 gene. This mutation is shared with FH rat, showing similar phenotypes to TM rats.  
 Breeding Conditions Good breeding performance. Sib mating. 
 Genotyping  
 References  Hieu HT, Tanaka M, Kuwamura M, Mashimo T, Serikawa T, Kuramoto T.
The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3.
Exp Anim. 2023 Feb 21;72(1):88-94.

Hamada S, Serikawa T, Yamada J.
TMラットの止血時間延長に関する遺伝学的検索
第32回日本実験動物学会総会講演要旨集． p117, 1985

Hamada S, Nishikawa T, Yokoi N, Serikawa T.
TM rats: a model for platelet storage pool deficiency.
Exp Anim. 1997 Jul;46(3):235-9.

Fujimori H, Ozaki K, Nomura S, Nishikawa T, Pan-Hou H, Nishimura M, Narama I.
Characterization of platelet abnormalities of Tester Moriyama (TM) rats with storage pool deficiency.
Lab Anim Sci. 1998 Oct;48(5):490-5.

Oiso N, Riddle SR, Serikawa T, Kuramoto T, Spritz RA.
The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain.
Mamm Genome. 2004 Apr;15(4):307-14.

Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.