Japanese
 NBRP Rat No: 0644 Strain Name: LAP/Hshyo Commmon Name: low alcohol preference rat
 Principal Investigator  Minori Nishiguchi
 Organization   Hyogo College of Medicine Department of Legal Medicine
 Address  1-1 Mukogawa-cho, Nishinomiya

663-8501 Hyogo

  Japan
 Telephone  +81-798-45-6578  Fax:  +81-798-49-3279  m-nishig@hyo-med.ac.jp
 Inbred Generations   64代目 
   
 Coat Color
 Deposition Status
 
 白色
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
1) Liver sytosolic aldehyde dehydrogenase (ALDH1) polymorphism and its inheritance in Wistar rats. Negoro, M., Hatake, K, Taniguchi, T., Ouchi, H., Minami, T. and Hishida, S. Jpn. J. Alcohol & Drug Dependence, 32(3): 182-188, 1997.
2) Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. Nishiguchi, M., Kinoshita, H.., Mostofa, J., Taniguchi, T., Ouchi, H., Minami, T., Hatake, K, Utsumi, T., Motomura, H. and Hishida, S. Alcohol. Alcohol., 37(1):9-12, 2002.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin High alcohol-preference (HAP) rats and Low alcohol-preference (LAP) rats were developed in the laboratory, Department of Legal Medicine, Hyogo College of Medicine, by selective inbreeding from the Wistar colony of rats. The ethanol preference of the rats was assessed by the one-lever two-liquid chamber method. (Iso and Sakaki, 1982).
 
 Strain Characteristics HAP and LAP rats show different ALDH1 phenotypes, different blood acetaldehyde concentration following ethanol administration, and different expression level of corticosterone and proopioomeranocortin. Furthermore HAP have a significantly higher sensitivity than LAP for methamphetamine.
 
 Breeding Conditions  
 Genotyping  
 References  1)　 Liver sytosolic aldehyde dehydrogenase (ALDH1) polymorphism and its inheritance in Wistar rats. Negoro, M., Hatake, K., Taniguchi, T., Ouchi, H., Minami, T. and Hishida, S. Jpn. J. Alcohol & Drug Dependence, 32 (3): 182-188, 1997.
2) アルコールの併用は高アルコール嗜好性ラットにおける覚せい剤の中枢神経作用を増強する. 山内順子, 丸川征四郎, 菱田　繁. 日本アルコール・薬物医学会雑誌, 35(1):28-47. 2000.
3) Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. Nishiguchi, M., Kinoshita, H., Mostofa, J., Taniguchi, T., Ouchi, H., Minami, T., Hatake, K., Utsumi, T., Motomura, H. and Hishida, S. Alcohol. Alcohol., 37 (1): 9-12, 2002.
4) 慢性アルコール摂取が覚せい剤の脳内ドパミンおよびセロトニン変化に及ぼす影響－アルコール嗜好性の異なるラット間での比較検討－. 西口美紀, 木下博之, 谷口忠昭, 内海隆生, 大内晴美, 南　貴子, 菱田　繁. Jpn. J. Alcohol & Drug Dependence, 37(6):555-576, 2002.
5) Decreased histamine-stimulated phosphoinositide hydrolysis in the cerebral cortex of arat line selectively bred for high alcohol preference. Kitanaka. N., Kitanaka. J., Nishiguchi. M., Kinoshota, H., et al. Neurochem Res. 29(7):1431-1436. 2004.
6) High alcohol preferring (HAP) and low alcohol preferring (LAP) rats show altered proopioomeranocortin (POMC) messenger RNA expression in the arcuate nucleus. Kinoshita, H., Harbuz, S. M., Nishiguchi, M., et al. Alcohol & Alcoholism, 39(5):406-409，2004.
7) Corticosterone concentration following ethanol administration in high alcohol preferring (HAP) and low alcohol preferring (LAP) rats. Kinoshita H, Takahashi M, Matsui K, Nishiguchi M, Ouchi H, Minami T, Hishida S, Jamal M, Ameno K. Current Study of Environmental and Medical Sciences 2:13-5, 2009.
8) Effects of dopamine antagonists on methamphetamine-induced dopamine release in high and low alcohol preference rats. Nishiguchi M, Kinoshita H, Kasuda S, Takahashi M, Yamamura T, Matsui K, Ouchi H, Minami T, Hishida S, Nishio H. Toxicology Mechanisms and Methods 20(3):127-132, 2010.